<?xml version="1.0" encoding="UTF-8"?>
<protein>
  <version>1.0</version>
  <creation_date>2018-05-07 22:22:07 UTC</creation_date>
  <update_date>2020-05-20 21:07:12 UTC</update_date>
  <accession>BMDBP00379</accession>
  <secondary_accessions>
    <accession>BMDBP03157</accession>
  </secondary_accessions>
  <protein_type>Enzyme</protein_type>
  <synonyms>
  </synonyms>
  <gene_name>SPR</gene_name>
  <general_function>Lipid transport and metabolism</general_function>
  <specific_function>Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin.</specific_function>
  <pathways>
  </pathways>
  <metabolite_associations>
    <metabolite>
      <accession>BMDB0000027</accession>
      <name>Tetrahydrobiopterin</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0000038</accession>
      <name>Dihydrobiopterin</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0000217</accession>
      <name>NADP</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0000221</accession>
      <name>NADPH</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0000238</accession>
      <name>Sepiapterin</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0001195</accession>
      <name>Dyspropterin</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0096081</accession>
      <name>1-hydroxy-2-Oxopropyl tetrahydropterin</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0002275</accession>
      <name>7,8-Dihydroneopterin</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0002065</accession>
      <name>6-Lactoyltetrahydropterin</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0000902</accession>
      <name>NAD</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0001487</accession>
      <name>NADH</name>
    </metabolite>
  </metabolite_associations>
  <go_classifications>
  </go_classifications>
  <subcellular_locations>
  </subcellular_locations>
  <gene_properties>
    <chromosome_location>11</chromosome_location>
    <locus/>
    <gene_sequence>&gt;804 bp
ATGGAGGGCAGCGTCGGCAAGGTGGGCGGCCTGGGGCGCACCTTATGCGTGCTGACTGGG
GCTTCCCGGGGCTTCGGACGGACGCTGGCCCAAGTCCTGGCCCCGCTGATGTCGCCTCGC
TCCGTGCTGGTCCTAAGCGCCCGCAATGACGAGGCCCTGCGGCAGCTGGAGACCGAGCTG
GGCGCCGAGTGGCCGGGTCTGCGTATCGTGCGGGTGCCCGCCGACCTGGGCGCCGAGACC
GGCTTGCAGCAACTGGTCGGTGCTCTGTGCGACCTCCCCAGGCCCGAGGGCCTGCAGCGA
GTGCTGCTCATCAACAATGCGGGCACTCTTGGAGATGTATCCAAACGTTGGGTGGACCTG
ACTGACCCAACTGAAGTGAACAACTACTGGACTCTGAACTTGACTTCCACGCTCTGCCTG
ACTTCCAGTATCCTGCAGGCCTTCCCGGACAGTCCTGGCCTCAGCAGGACTGTGGTTAAC
ATCTCGTCCATCTGTGCCCTGCAGCCCTTCAAGGGCTGGGGACTGTACTGTGCTGGGAAG
GCTGCCCGTAACATGATGTTCCAGGTCCTGGCGGCGGAGGAACCTAGCGTGAGGGTGCTG
AGCTATGGCCCAGGTCCCCTGGACACTGACATGCAGCAGTTAGCCCGGGAGACCTCTGTG
GACCCAGACTTGCGAAAAAGCCTGCAGGAGCTGAAGAGAAAGGGGCAACTTGTGGATTGC
AAGATATCAGCCCAGAAACTTCTGAGCTTGCTGCAAAATGACAAGTTCGAGTCTGGAGCC
CATATTGACTTCTACGATGAATAA</gene_sequence>
  </gene_properties>
  <protein_properties>
    <residue_number>267</residue_number>
    <molecular_weight>28939.0</molecular_weight>
    <theoretical_pi>5.15</theoretical_pi>
    <pfams>
    </pfams>
    <transmembrane_regions>
    </transmembrane_regions>
    <signal_regions>
      <region>None</region>
    </signal_regions>
    <polypeptide_sequence>&gt;Sepiapterin reductase
MEGSVGKVGGLGRTLCVLTGASRGFGRTLAQVLAPLMSPRSVLVLSARNDEALRQLETEL
GAEWPGLRIVRVPADLGAETGLQQLVGALCDLPRPEGLQRVLLINNAGTLGDVSKRWVDL
TDPTEVNNYWTLNLTSTLCLTSSILQAFPDSPGLSRTVVNISSICALQPFKGWGLYCAGK
AARNMMFQVLAAEEPSVRVLSYGPGPLDTDMQQLARETSVDPDLRKSLQELKRKGELVDC
KISAQKLLSLLQNDKFESGAHIDFYDE</polypeptide_sequence>
  </protein_properties>
  <genbank_protein_id>ABI79460.1</genbank_protein_id>
  <uniprot_id>Q17QK8</uniprot_id>
  <uniprot_name>SPRE_BOVIN</uniprot_name>
  <pdb_ids>
  </pdb_ids>
  <genbank_gene_id>DQ978331</genbank_gene_id>
  <genecard_id>SPR</genecard_id>
  <geneatlas_id/>
  <general_references>
  </general_references>
  <metabolite_references>
  </metabolite_references>
</protein>
