1.0 2018-05-07 22:22:34 UTC 2020-05-20 21:07:20 UTC BMDBP00477 Enzyme FHIT Nucleotide transport and metabolism Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity. Functions as tumor suppressor (By similarity). BMDB0000464 Calcium BMDB0000547 Magnesium BMDB0000608 Cobalt BMDB0001333 Manganese BMDB0001341 ADP BMDB0002457 Nickel BMDB0003638 Cadmium 22 >450 bp ATGTCGTTCAGATTTGGCCAACATCTCATCAAGCCCTCGGTGGTGTTTCTCAAAACAGAA CTGTCCTTTGCCCTGGTGAACAGGAAGCCTGTGGTACCTGGACATGTCCTCGTGTGTCCC CTCCGGCCAGTGGAGCGCTTCCGAGACATGAGTCCTGAAGAAGTGGCTGACTTGTTTCAG GCAGCACAGAGAGTCGGCACGGTGGTAGAGAAGCATTTCCAGGGCACCTCGCTCACGTTT TCCATGCAGGATGGCCCCGAAGCCGGACAGACTGTGAAGCATGTTCACGTCCACATTCTT CCAAGGAAGGCTGGAGACTTTCACAGGAATGACAGCATCTATGATGCGCTCGAGAAACAC GACAGAGAGGATAAAGACTCCCCAGCCTTGTGGCGGTCAGAGGAGGAAATGGCAGCTGAG GCTGCAGCGCTGAGGGTCTACTTTCAGTGA 149 16951.0 6.97 None >Bis(5'-adenosyl)-triphosphatase MSFRFGQHLIKPSVVFLKTELSFALVNRKPVVPGHVLVCPLRPVERFRDMSPEEVADLFQ AAQRVGTVVEKHFQGTSLTFSMQDGPEAGQTVKHVHVHILPRKAGDFHRNDSIYDALEKH DREDKDSPALWRSEEEMAAEAAALRVYFQ ABC61315.1 Q1KZG4 FHIT_BOVIN DQ335870 FHIT