1.0 2018-05-07 22:22:42 UTC 2020-05-20 21:09:42 UTC BMDBP00507 Enzyme NME2 Nucleotide transport and metabolism Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically. Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter. Does not bind to duplex NHE III(1). Has G-quadruplex (G4) DNA-binding activity, which is independent of its nucleotide-binding and kinase activity. Binds both folded and unfolded G4 with similar low nanomolar affinities. Stabilizes folded G4s regardless of whether they are prefolded or not (By similarity). Exhibits histidine protein kinase activity (PubMed:12486123). Lactose Synthesis SMP0087229 BMDB0000250 Pyrophosphate BMDB0000547 Magnesium BMDB0001341 ADP BMDB0012282 PPPi BMDB0000538 Adenosine triphosphate BMDB0000295 Uridine 5'-diphosphate BMDB0000285 Uridine triphosphate 19 >459 bp ATGGCCCACGCGGAGCGCACCTTTATTGCTATCAAGCCGGACGGCGTGCAGCGCGGCCTG GTGGGCGAGATCATCAAGCGCTTCGAGCAGAAGGGATTCCGCCTTGTGGCCATGAAGTTC CTTCAGGCCTCTGAGGAACTCCTGAAGCAGCACTACATTGACCTGAAAGACCGCCCATTC TTTCCCGGCCTGGTGAAGTACATGAACTCAGGGCCAGTTGTGGCCATGGTCTGGGAGGGC CTGAATGTAGTGAAGACAGGACGAGTGATGCTTGGGGAGACCAACCCAGCAGATTCTAAG CCGGGCACCATTCGTGGTGACTTCTGCATTCAAGTTGGCAGGAACATCATTCATGGCAGT GATTCAGTAAAAAGTGCTGAGAAAGAGATCAACTTGTGGTTTAAGCCCGAAGAATTGATT GAATACAAGCCTTGTGCTTTTGACTGGATATATGAATAA 152 17316.0 8.22 None >Nucleoside diphosphate kinase B MAHAERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLQASEELLKQHYIDLKDRPF FPGLVKYMNSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGS DSVKSAEKEINLWFKPEELIEYKPCAFDWIYE AAI02301.1 Q3T0Q4 NDKB_BOVIN 1NSK BC102300 NME2