1.0 2018-05-07 22:24:35 UTC 2020-05-20 21:05:04 UTC BMDBP00915 Enzyme PIK3R1 Replication, recombination and repair Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (By similarity). Fc Epsilon Receptor I Signaling in Mast Cells SMP0108186 Phosphatidylinositol Phosphate Metabolism SMP0087258 T Cell Receptor Signaling Pathway SMP0120935 BMDB0000122 D-Glucose BMDB0000158 L-Tyrosine BMDB0000757 Glycogen 20 724 83497.0 6.03 None >Phosphatidylinositol 3-kinase regulatory subunit alpha MSAEGYQYRALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSDGQEAKPEEIGWLNGYN ETTGERGDFPGTYVEYIGRKKISPPTPKPRPPRPLPVAPGPSKTEADSEQQASTLPDLAE QFAPPDVAPPLLIKLVEAIEKKGLECSTLYRTQSSSNPAELRQLLDCDTASLDLEMFDVH VLADAFKRYLLDLPNPVIPVAVSSELISLAPEVQSSEEYIQLLKKLIRSPSIPHQYWLTL QYLLKHFFKLSQTSSKNLLNARVLSELFSPLLFRFPAASSENTEHLIKIIEILISTEWNE RQPAPALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDA STKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFNSVVELINHYRNESLAQYNPKL DVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEDYTRTSQEIQMK RTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNETEIQRIMHNYEKLKSRISEIVD SRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGN ENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACS VVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYA QQRR AAA79511.1 P23727 P85A_BOVIN 1BFI 1BFJ 1OO3 1OO4 1PNJ 1QAD 2PNA 2PNB 2PNI 5DXH 5DXU 5T8F 6D81 6D82 6D85 6D86 6D87 6G6W 6MRP 6OCO 6OCU 6R4R 1BFI 1OO3 1OO4 1PNJ 1QAD 2PNA 5DXU 6D85 6R4R M61745 PIK3R1