1.0 2018-05-07 22:25:42 UTC 2020-05-20 21:04:32 UTC BMDBP01158 BMDBP03166 Enzyme PRKACB Involved in ATP binding Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, and differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates GPKOW which regulates its ability to bind RNA. BMDB0001341 ADP BMDB0000058 Cyclic AMP BMDB0000973 Hydrogen phosphate 3 >1056 bp CCTTCCTCCCATCGCCCCAGTCATGGGGAACGCGGCGACCGCCAAGAAAGGCAGCGAGGT GGAGAGCGTGAAAGAGTTTCTAGCCAAAGCCAAAGAAGACTTTTTAAAAAAATGGGAAAA TCCTGCTCCGAATAATGCTGGGCTGGAGGATTTTGAAAGGAAAAAAACCCTTGGAACAGG TTCATTTGGAAGAGTCATGTTGGTGAAACACAAAGCCACTGAACAGTATTATGCCATGAA GATCTTAGATAAGCAGAAGGTTGTTAAACTGAAGCAAATAGAGCATACTTTGAATGAGAA AAGAATATTACAGGCAGTGAATTTTCCTTTTCTTGTTCGACTGGAATATGCTTTTAAGGA TAATTCTAATTTATACATGGTTATGGAATATGTTCCTGGTGGTGAAATGTTTTCACATCT AAGAAGAATTGGAAGGTTCAGTGAACCCCATGCACGGTTCTATGCAGCTCAGATAGTGCT AACATTCGAGTACCTCCATTCACTAGACCTCATCTACAGAGATCTAAAACCTGAAAATCT CTTAATTGACCACCAAGGTTATATCCAGGTCACAGACTTTGGGTTTGCCAAAAGAGTTAA AGGCAGAACTTGGACATTATGTGGCACTCCAGAATATTTGGCTCCAGAAATCATTCTCAG CAAGGGCTACAATAAGGCAGTGGATTGGTGGGCGTTAGGAGTGTTAATCTATGAAATGGC GGCTGGCTACCCCCCATTCTTTGCAGACCAACCAATTCAGATTTATGAAAAAATTGTTTC TGGAAAGGTTCGATTCCCTTCTCACTTCAGTTCAGATCTCAAGGACCTTCTAAGGAACCT GCTGCAGGTAGACTTAACAAAGCGGTTTGGAAATCTAAAGAATGGTGTGAGTGACATAAA AACTCACAAGTGGTTTGCCACAACAGACTGGATTGCTATTTACCAGAGAAAGGTTGAAGC TCCATTCATACCAAAGTTCAGAGGCTCTGGAGATACCAGCAACTTTGATGACTATGAAGA AGAAGATATCCGTGTCTCTATAACAGAAAAATGTGG 351 40594.0 9.06 None >cAMP-dependent protein kinase catalytic subunit beta MGNAATAKKGSEVESVKEFLAKAKEDFLKKWENPAPNNAGLEDFERKKTLGTGSFGRVML VKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMV MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGY IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF ADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFAT TDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEEDIRVSITEKCGKEFCEF AAA30707.1 P05131 KAPCB_BOVIN 1CTP J02647 PRKACB