1.0 2018-05-07 22:29:59 UTC 2020-05-20 21:09:58 UTC BMDBP02090 Enzyme NUDT21 Involved in hydrolase activity Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs. NUDT21/CPSF5 activates indirectly the mRNA 3'-processing machinery by recruiting CPSF6 and/or CPSF7. Binds to 5'-UGUA-3' elements localized upstream of pA signals that act as enhancers of pre-mRNA 3'-end processing. The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA. Plays a role in somatic cell fate transitions and pluripotency by regulating widespread changes in gene expression through an APA-dependent function. Binds to chromatin. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. BMDB0000050 Adenosine 18 >684 bp ATGTCCGTGGTGCCGCCCAATCGCTCGCAGACCGGCTGGCCCCGGGGAGTCACCCAGTTC GGCAACAAGTATATCCAGCAGACCAAGCCCCTCACCCTGGAGCGCACCATCAACCTGTAC CCTCTTACCAATTACACTTTTGGTACAAAAGAACCCCTCTATGAGAAGGACAGCTCTGTT GCAGCCAGATTTCAGCGCATGAGGGAGGAATTTGATAAAATTGGCATGAGGAGGACTGTA GAAGGGGTTTTGATTGTCCATGAGCACCGGCTACCCCATGTGTTACTGCTACAGCTGGGA ACAACGTTCTTCAAATTACCTGGTGGTGAGCTTAATCCAGGAGAAGATGAAGTTGAAGGA CTAAAACGCTTAATGACAGAGATATTGGGTCGTCAAGATGGAGTCCTGCAAGACTGGGTT ATCGATGACTGCATTGGCAACTGGTGGAGACCAAATTTTGAGCCTCCTCAGTATCCATAT ATTCCTGCACATATTACAAAACCTAAGGAACATAAGAAGTTGTTTCTGGTTCAGCTTCAA GAGAAAGCCTTGTTTGCAGTCCCTAAAAATTACAAGCTGGTAGCTGCACCGCTATTTGAA CTGTATGACAATGCACCTGGATATGGACCCATCATTTCTAGTCTCCCCCAGCTTTTGAGC AGGTTCAATTTTATATACAACTGA 227 26227.0 9.18 None >Cleavage and polyadenylation specificity factor subunit 5 MSVVPPNRSQTGWPRGVTQFGNKYIQQTKPLTLERTINLYPLTNYTFGTKEPLYEKDSSV AARFQRMREEFDKIGMRRTVEGVLIVHEHRLPHVLLLQLGTTFFKLPGGELNPGEDEVEG LKRLMTEILGRQDGVLQDWVIDDCIGNWWRPNFEPPQYPYIPAHITKPKEHKKLFLVQLQ EKALFAVPKNYKLVAAPLFELYDNAPGYGPIISSLPQLLSRFNFIYN AAI02698.1 Q3ZCA2 CPSF5_BOVIN BC102697 NUDT21