1.0 2018-05-07 22:32:19 UTC 2020-05-20 21:07:52 UTC BMDBP02599 Enzyme CISH Involved in intracellular signaling cascade SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation (By similarity). May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Protein modification Protein ubiquitination BMDB0000158 L-Tyrosine 22 >765 bp ATGGTCCTCTGCGTTCAGGGACTTTGTCCTTTGCTGGCCGTGGAGCAGATTGGGCAGCGG CCCCTGTGGGCCCAGTCCCTGGAGCTGCCCCAGCAAGTTATGCAGCCTTTGTCTGCTGGC GCCTTCCTGGAGGAGGCAGTAGAGGAGTCCCCAGCCCAGCCAGAGAGGGAGCCCAAGGTG GTGGACCCCGAGGAGGACCTGCTGTGCATAGCCAAGACCTTCTCCTACCTTCGGGAATCT GGCTGGTACTGGGGTTCCATTACGGCCAGTGAGGCCCGGCAACACCTTCAGAAGATGCCA GAGGGCACCTTCCTGGTACGTGACAGCACCCACCCCAGCTACCTGTTCACACTGTCCGTC AAGACCACCCGCGGGCCCACCAACGTGCGCATTGAGTACGCCGACTCCAGCTTCCGCCTG GACTCCAACTGCCTGTCCAGGCCTCGCATCCTGGCCTTCCCAGATGTGGTGAGCCTGGTC CAGCACTACGTGGCCTCCTGTGCTGCAGACACCCGGAGTGACAGTCCCGACCTTGCCACC ACCCCGGCCCTGCCCACCCCGAAGGAAGATGCGCCCGGTGACCCAGCCCTGCCCGCCACG GCCGTTCACCTGAAACTGGTACAGCCCTTTGTGCGCAGGAGCAGCACCCGGAGCCTGCAG CACCTGTGCCGCCTGGTCATCAACCGCCTGGTGGTCGACGTGGACTGCCTGCCGCTTCCC CGGCGCATGGCTGACTACCTCCGACAATACCCCTTCCAGCTCTGA 254 28397.0 6.03 None >Cytokine-inducible SH2-containing protein MVLCVQGLCPLLAVEQIGQRPLWAQSLELPQQVMQPLSAGAFLEEAVEESPAQPEREPKV VDPEEDLLCIAKTFSYLRESGWYWGSITASEARQHLQKMPEGTFLVRDSTHPSYLFTLSV KTTRGPTNVRIEYADSSFRLDSNCLSRPRILAFPDVVSLVQHYVASCAADTRSDSPDLAT TPALPTPKEDAPGDPALPATAVHLKLVQPFVRRSSTRSLQHLCRLVINRLVVDVDCLPLP RRMADYLRQYPFQL AAI13308.1 Q2HJ53 CISH_BOVIN BC113307 CISH