| Record Information |
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| Version | 1.0 |
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| Creation Date | 2016-09-30 22:53:26 UTC |
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| Update Date | 2020-05-11 20:40:01 UTC |
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| BMDB ID | BMDB0002273 |
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| Secondary Accession Numbers | |
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| Metabolite Identification |
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| Common Name | 4-Hydroxy-L-glutamic acid |
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| Description | 4-Hydroxy-L-glutamic acid, also known as 4-hydroxy-L-glutamate or erythro-L-bhga, belongs to the class of organic compounds known as glutamic acid and derivatives. Glutamic acid and derivatives are compounds containing glutamic acid or a derivative thereof resulting from reaction of glutamic acid at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom. 4-Hydroxy-L-glutamic acid is possibly soluble (in water) and a very strong basic compound (based on its pKa). 4-Hydroxy-L-glutamic acid exists in all living organisms, ranging from bacteria to humans. 4-Hydroxy-L-glutamic acid participates in a number of enzymatic reactions, within cattle. In particular, 4-Hydroxy-L-glutamic acid can be biosynthesized from pyrroline hydroxycarboxylic acid through the action of the enzyme Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial. In addition, 4-Hydroxy-L-glutamic acid can be converted into L-4-hydroxyglutamate semialdehyde through the action of the enzyme proline dehydrogenase 1, mitochondrial. In cattle, 4-hydroxy-L-glutamic acid is involved in the metabolic pathway called the arginine and proline metabolism pathway. |
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| Structure | |
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| Synonyms | | Value | Source |
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| 4-Hydroxy-L-glutamate | Generator | | beta-Hydroxyglutamate | HMDB | | beta-Hydroxyglutamic acid | HMDB | | Erythro-L-bhga | HMDB | | Hydroxyglutamic acid, (DL)-isomer | HMDB | | Hydroxyglutamic acid, erythro-(DL)-isomer | HMDB | | Hydroxyglutamic acid, erythro-(L)-isomer | HMDB | | Hydroxyglutamic acid, sodium salt | HMDB | | Threo-L-bhga | HMDB |
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| Chemical Formula | C5H9NO5 |
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| Average Molecular Weight | 163.129 |
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| Monoisotopic Molecular Weight | 163.048072394 |
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| IUPAC Name | Not Available |
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| Traditional Name | Not Available |
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| CAS Registry Number | 2485-33-8 |
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| SMILES | Not Available |
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| InChI Identifier | InChI=1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11) |
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| InChI Key | HBDWQSHEVMSFGY-UHFFFAOYSA-N |
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| Chemical Taxonomy |
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| Description | belongs to the class of organic compounds known as glutamic acid and derivatives. Glutamic acid and derivatives are compounds containing glutamic acid or a derivative thereof resulting from reaction of glutamic acid at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom. |
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| Kingdom | Organic compounds |
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| Super Class | Organic acids and derivatives |
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| Class | Carboxylic acids and derivatives |
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| Sub Class | Amino acids, peptides, and analogues |
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| Direct Parent | Glutamic acid and derivatives |
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| Alternative Parents | |
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| Substituents | - Glutamic acid or derivatives
- Alpha-amino acid
- Amino fatty acid
- Hydroxy fatty acid
- Short-chain hydroxy acid
- Alpha-hydroxy acid
- Dicarboxylic acid or derivatives
- Hydroxy acid
- Fatty acid
- Fatty acyl
- 1,3-aminoalcohol
- Secondary alcohol
- Amino acid
- Carboxylic acid
- Primary amine
- Primary aliphatic amine
- Organopnictogen compound
- Alcohol
- Organonitrogen compound
- Carbonyl group
- Organic oxygen compound
- Amine
- Organic oxide
- Organic nitrogen compound
- Organooxygen compound
- Hydrocarbon derivative
- Aliphatic acyclic compound
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| Molecular Framework | Aliphatic acyclic compounds |
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| External Descriptors | Not Available |
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| Ontology |
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| Status | Expected but not Quantified |
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| Origin | |
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| Biofunction | Not Available |
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| Application | Not Available |
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| Cellular locations | Not Available |
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| Physical Properties |
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| State | Solid |
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| Experimental Properties | | Property | Value | Reference |
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| Melting Point | Not Available | Not Available | | Boiling Point | Not Available | Not Available | | Water Solubility | Not Available | Not Available | | LogP | Not Available | Not Available |
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| Predicted Properties | Not Available |
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| Spectra |
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| Spectra | |
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