Showing metabocard for 6β-Hydroxytestosterone (BMDB0006259)

IdentificationTaxonomyPhysical propertiesPathwaysSpectraConcentrationsLinksReferencesXML
Record Information
Version1.0
Creation Date2016-09-30 23:20:58 UTC
Update Date2020-05-11 20:24:38 UTC
BMDB IDBMDB0006259
Secondary Accession Numbers
  • BMDB06259
Metabolite Identification
Common Name6β-Hydroxytestosterone
Description6beta-Hydroxytestosterone, also known as 4-androsten-6b,17b-diol-3-one, belongs to the class of organic compounds known as androgens and derivatives. These are 3-hydroxylated C19 steroid hormones. They are known to favor the development of masculine characteristics. They also show profound effects on scalp and body hair in humans. Thus, 6beta-hydroxytestosterone is considered to be a steroid. Based on a literature review a significant number of articles have been published on 6beta-Hydroxytestosterone.
Structure
Thumb
MOLSDF3D-SDFPDBSMILESInChI View 3D Structure
Synonyms
ValueSource
(6beta,17beta)-6,17-Dihydroxyandrost-4-en-3-oneChEBI
4-Androsten-6beta,17beta-diol-3-oneChEBI
6beta,17beta-Dihydroxy-4-androsten-3-oneChEBI
6beta,17beta-Dihydroxyandrost-4-en-3-oneChEBI
(6b,17b)-6,17-Dihydroxyandrost-4-en-3-oneGenerator
(6Β,17β)-6,17-dihydroxyandrost-4-en-3-oneGenerator
4-Androsten-6b,17b-diol-3-oneGenerator
4-Androsten-6β,17β-diol-3-oneGenerator
6b,17b-Dihydroxy-4-androsten-3-oneGenerator
6Β,17β-dihydroxy-4-androsten-3-oneGenerator
6b,17b-Dihydroxyandrost-4-en-3-oneGenerator
6Β,17β-dihydroxyandrost-4-en-3-oneGenerator
6b-HydroxytestosteroneGenerator
6Β-hydroxytestosteroneGenerator
6 beta-HydroxytestosteroneMeSH
6 beta-Hydroxytestosterone, (17beta)-isomerMeSH
6 beta-Hydroxytestosterone, (6alpha,17beta)-isomerMeSH
6 beta Hydroxy testosteroneHMDB
6,17-Dihydroxy-(6b,17b)-androst-4-en-3-oneHMDB
6,17-Dihydroxy-(6beta,17beta)-androst-4-en-3-oneHMDB
6,17-Dihydroxyandrost-4-en-3-one (acd/name 4.0)HMDB
Chemical FormulaC19H28O3
Average Molecular Weight304.4238
Monoisotopic Molecular Weight304.203844762
IUPAC Name(1S,2R,8R,10R,11S,14S,15S)-8,14-dihydroxy-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-6-en-5-one
Traditional Name6β-hydroxytestosterone
CAS Registry Number62-99-7
SMILES
[H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])C[C@@H](O)C2=CC(=O)CC[C@]12C
InChI Identifier
InChI=1S/C19H28O3/c1-18-7-5-11(20)9-15(18)16(21)10-12-13-3-4-17(22)19(13,2)8-6-14(12)18/h9,12-14,16-17,21-22H,3-8,10H2,1-2H3/t12-,13-,14-,16+,17-,18+,19-/m0/s1
InChI KeyXSEGWEUVSZRCBC-ZVBLRVHNSA-N
Chemical Taxonomy
Description belongs to the class of organic compounds known as androgens and derivatives. These are 3-hydroxylated C19 steroid hormones. They are known to favor the development of masculine characteristics. They also show profound effects on scalp and body hair in humans.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassSteroids and steroid derivatives
Sub ClassAndrostane steroids
Direct ParentAndrogens and derivatives
Alternative Parents
Substituents
  • Androgen-skeleton
  • 3-oxo-delta-4-steroid
  • 3-oxosteroid
  • 17-hydroxysteroid
  • Oxosteroid
  • 6-hydroxysteroid
  • Hydroxysteroid
  • Delta-4-steroid
  • Cyclohexenone
  • Cyclic alcohol
  • Cyclic ketone
  • Secondary alcohol
  • Ketone
  • Organic oxygen compound
  • Carbonyl group
  • Hydrocarbon derivative
  • Organic oxide
  • Organooxygen compound
  • Alcohol
  • Aliphatic homopolycyclic compound
Molecular FrameworkAliphatic homopolycyclic compounds
External Descriptors
Ontology
StatusExpected but not Quantified
Origin
  • Endogenous
  • Exogenous
BiofunctionNot Available
ApplicationNot Available
Cellular locations
  • Cell membrane
  • Cytoplasm
  • Endoplasmic reticulum
  • Membrane
Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP2.09ALOGPS
logP2.13ChemAxon
logS-3.5ALOGPS
pKa (Strongest Acidic)14.55ChemAxon
pKa (Strongest Basic)-0.88ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area57.53 ŲChemAxon
Rotatable Bond Count0ChemAxon
Refractivity85.95 m³·mol⁻¹ChemAxon
Polarizability34.69 ųChemAxon
Number of Rings4ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Spectra
Biological Properties
Cellular Locations
  • Cell membrane
  • Cytoplasm
  • Endoplasmic reticulum
  • Membrane
Biospecimen Locations
  • Kidney
  • Liver
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
KidneyExpected but not QuantifiedNot QuantifiedNot SpecifiedNot SpecifiedNormal
  • Not Applicable
 details
LiverExpected but not QuantifiedNot QuantifiedNot SpecifiedNot SpecifiedNormal
  • Not Applicable
 details
Abnormal Concentrations
Not Available
HMDB IDHMDB0006259
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB023864
KNApSAcK IDNot Available
Chemspider ID18558308
KEGG Compound IDC14497
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkNot Available
METLIN IDNot Available
PubChem Compound18603089
PDB IDNot Available
ChEBI ID34477
References
Synthesis ReferenceFuruta Takashi; Suzuki Atsushi; Matsuzawa Mitsuhiro; Shibasaki Hiromi; Kasuya Yasuji Syntheses of stable isotope-labeled 6 beta-hydroxycortisol, 6 beta-hydroxycortisone, and 6 beta-hydroxytestosterone. Steroids (2003), 68(7-8), 693-703.
Material Safety Data Sheet (MSDS)Not Available
General ReferencesNot Available