| Record Information |
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| Version | 1.0 |
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| Creation Date | 2016-10-03 18:38:51 UTC |
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| Update Date | 2020-04-22 15:50:27 UTC |
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| BMDB ID | BMDB0012453 |
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| Secondary Accession Numbers | |
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| Metabolite Identification |
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| Common Name | 3 beta-Hydroxy-5-cholestenoate |
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| Description | PS(16:1(9Z)/18:1(9Z)) is a phosphatidylserine. It is a glycerophospholipid in which a phosphorylserine moiety occupies a glycerol substitution site. As is the case with diacylglycerols, phosphatidylserines can have many different combinations of fatty acids of varying lengths and saturation attached to the C-1 and C-2 atoms. PS(16:1(9Z)/18:1(9Z)), in particular, consists of one 9Z-hexadecenoyl chain to the C-1 atom, and one 9Z-octadecenoyl to the C-2 atom. Phosphatidylserine or 1,2-diacyl-sn-glycero-3-phospho-L-serine is distributed widely among animals, plants and microorganisms. Phosphatidylserine is an acidic (anionic) phospholipid with three ionizable groups, i.e. the phosphate moiety, the amino group and the carboxyl function. As with other acidic lipids, it exists in nature in salt form, but it has a high propensity to chelate to calcium via the charged oxygen atoms of both the carboxyl and phosphate moieties, modifying the conformation of the polar head group. This interaction may be of considerable relevance to the biological function of phosphatidylserine. While most phospholipids have a saturated fatty acid on C-1 and an unsaturated fatty acid on C-2 of the glycerol backbone, the fatty acid distribution at the C-1 and C-2 positions of glycerol within phospholipids is continually in flux, owing to phospholipid degradation and the continuous phospholipid remodeling that occurs while these molecules are in membranes. Phosphatidylserines typically carry a net charge of -1 at physiological pH. They mostly have palmitic or stearic acid on carbon 1 and a long chain unsaturated fatty acid (e.g. 18:2, 20:4 and 22:6) on carbon 2. PS biosynthesis involves an exchange reaction of serine for ethanolamine in PE. |
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| Structure | |
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| Synonyms | | Value | Source |
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| 1-Palmitoleoyl-2-oleoyl-sn-glycero-3-phosphoserine | HMDB | | Phosphatidylserine(16:1/18:1) | HMDB | | Phosphatidylserine(16:1n7/18:1n9) | HMDB | | Phosphatidylserine(16:1W7/18:1W9) | HMDB | | Phosphatidylserine(34:2) | HMDB | | PS(16:1/18:1) | HMDB | | PS(16:1N7/18:1N9) | HMDB | | PS(16:1W7/18:1W9) | HMDB | | PS(34:2) | HMDB | | pSer(16:1/18:1) | HMDB | | pSer(16:1n7/18:1n9) | HMDB | | pSer(16:1W7/18:1W9) | HMDB | | pSer(34:2) | HMDB | | 1-(9Z-Hexadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoserine | HMDB | | (3beta)-3-Hydroxy-cholest-5-en-26-Oate | HMDB | | (3beta)-3-Hydroxy-cholest-5-en-26-Oic acid | HMDB | | 3 beta-Hydroxycholest-5-en-27-Oate | HMDB | | 3 beta-Hydroxycholest-5-en-27-Oic acid | HMDB | | 3-HCOA | HMDB, MeSH | | 3-Hydroxy-5-cholesten-26-Oate | HMDB | | 3-Hydroxy-5-cholesten-26-Oic acid | HMDB, MeSH | | 3-Hydroxy-5-cholestenoate | HMDB | | 3-Hydroxy-5-cholestenoic acid | HMDB, MeSH | | 3beta-Hydroxy-5-cholesten-26-Oate | HMDB | | 3beta-Hydroxy-5-cholesten-26-Oic acid | HMDB | | 3beta-Hydroxy-5-cholestenoate | HMDB | | 3beta-Hydroxy-5-cholestenoic acid | HMDB | | 3 b-Hydroxy-5-cholestenoate | Generator | | 3 b-Hydroxy-5-cholestenoic acid | Generator | | 3 beta-Hydroxy-5-cholestenoic acid | Generator | | 3 Β-hydroxy-5-cholestenoate | Generator | | 3 Β-hydroxy-5-cholestenoic acid | Generator | | 3-Hydroxy-5-cholestenoic acid, (3beta,25S)-isomer | MeSH | | 3-Hydroxy-5-cholestenoic acid, 26-14(C)-labeled | MeSH | | 3-Hydroxycholest-5-en-26-Oic acid | MeSH | | 3 beta-Hydroxy-5-cholesten-26-Oic acid | MeSH | | 3-Hydroxy-5-cholestenoic acid, (3beta,25R)-isomer | MeSH |
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| Chemical Formula | C27H44O3 |
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| Average Molecular Weight | 416.6365 |
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| Monoisotopic Molecular Weight | 416.329045274 |
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| IUPAC Name | (6R)-6-[(2R,5S,15R)-5-hydroxy-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-7-en-14-yl]-2-methylheptanoic acid |
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| Traditional Name | (6R)-6-[(2R,5S,15R)-5-hydroxy-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-7-en-14-yl]-2-methylheptanoic acid |
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| CAS Registry Number | 6561-58-6 |
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| SMILES | C[C@H](CCCC(C)C(O)=O)C1CCC2C3CC=C4C[C@@H](O)CC[C@]4(C)C3CC[C@]12C |
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| InChI Identifier | InChI=1S/C27H44O3/c1-17(6-5-7-18(2)25(29)30)22-10-11-23-21-9-8-19-16-20(28)12-14-26(19,3)24(21)13-15-27(22,23)4/h8,17-18,20-24,28H,5-7,9-16H2,1-4H3,(H,29,30)/t17-,18?,20+,21?,22?,23?,24?,26+,27-/m1/s1 |
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| InChI Key | WVXOMPRLWLXFAP-UBJAGWMESA-N |
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| Chemical Taxonomy |
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| Description | belongs to the class of organic compounds known as phosphatidylserines. These are glycerophosphoserines in which two fatty acids are bonded to the glycerol moiety through ester linkages. As is the case with diacylglycerols, phosphatidylserines can have many different combinations of fatty acids of varying lengths and saturation attached to the C-1 and C-2 positions. |
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| Kingdom | Organic compounds |
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| Super Class | Lipids and lipid-like molecules |
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| Class | Glycerophospholipids |
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| Sub Class | Glycerophosphoserines |
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| Direct Parent | Phosphatidylserines |
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| Alternative Parents | |
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| Substituents | - Diacyl-glycerol-3-phosphoserine
- Alpha-amino acid
- Alpha-amino acid or derivatives
- L-alpha-amino acid
- Tricarboxylic acid or derivatives
- Phosphoethanolamine
- Fatty acid ester
- Dialkyl phosphate
- Organic phosphoric acid derivative
- Phosphoric acid ester
- Alkyl phosphate
- Fatty acyl
- Amino acid
- Amino acid or derivatives
- Carboxylic acid ester
- Carboxylic acid derivative
- Carboxylic acid
- Primary aliphatic amine
- Organopnictogen compound
- Organic oxygen compound
- Organic nitrogen compound
- Amine
- Carbonyl group
- Organic oxide
- Primary amine
- Hydrocarbon derivative
- Organonitrogen compound
- Organooxygen compound
- Aliphatic acyclic compound
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| Molecular Framework | Aliphatic acyclic compounds |
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| External Descriptors | |
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| Ontology |
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| Status | Expected but not Quantified |
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| Origin | |
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| Biofunction | Not Available |
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| Application | Not Available |
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| Cellular locations | |
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| Physical Properties |
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| State | Solid |
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| Experimental Properties | | Property | Value | Reference |
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| Melting Point | Not Available | Not Available | | Boiling Point | Not Available | Not Available | | Water Solubility | Not Available | Not Available | | LogP | Not Available | Not Available |
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| Predicted Properties | |
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| Spectra |
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| Spectra | |
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