Coat colour, brown, TYRP1-related
Phenotype Details
- Phene ID
- 2232
- Name
- Coat colour, brown, TYRP1-related
- Phene Name
- Dun coat colour in Dexter cattle
- OMIA ID
- 1249
- Species ID
- 9913
- Characterised
- Yes
- Characterised Year
- 2003
Linked Genes
| Symbol | Gene ID | Chromosome | Description |
|---|---|---|---|
| TYRP1 | 282105 | 8 | tyrosinase-related protein 1 |
Linked Variants
| Variant ID | Phenotype | Gene ID | Deleterious | Chromosome | Genomic | Transcript | Protein |
|---|---|---|---|---|---|---|---|
| 184 | Dun brown | 282105 | 0 | 8 | NC_037335.1:g.31633328G>A | NM_174480.3:c.1300C>T | NP_776905.2:p.(H434Y) |
Linked Breeds
| Breed | Breed ID | Species ID | VBO Term |
|---|---|---|---|
| Dexter (Cattle) | 36 | 9913 | http://purl.obolibrary.org/obo/VBO_0000193 |
Molecular Genetics
Armed with the knowledge that TYRP1 in Dexter cattle is a strong positional candidate gene for the dun phenotype (see Mapping section above), Berryere et al. (2003) showed that dun brown coat colour in Dexter cattle is due to homozygosity for a H434Y amino acid substitution in TYRP1, due to "a C to T change in nucleotide 1300 within exon 7" of the TYRP1 gene. [FN 10 Sep 2005; 21 Sep 2012]. See also OMIA:001821-9913 : Coat colour, albinism, oculocutaneous type IV for a SLC45A2 variant causing a differnt form of dilution coat colour in Dexter cattle.