Neuronal Ceroid Lipofuscinosis, generic

Phene ID

356

Name

Neuronal Ceroid Lipofuscinosis, generic

Phene Name

Neuronal ceroid lipofuscinosis

OMIA ID

181

Species ID

9913

Characterised

No

Characterised Year

N/A

In cattle, neuronal ceroid lipofuscinosis has been described in an inbreed herd of Beefmaster cattle in 1969 in the USA and in a herd of Devon cattle in Australia in 1988. The disease is characterised predominantly by blindness and behavioural changes. The clinical signs and the pathological findings are similar in both breeds, with less detailed records for the Beefmaster cattle. Nevertheless, NCL in Beefmaster and Devon cattle could represent different variants of this heterogenous group of diseases. In comparison to NCL in other species, brain atrophy in Devon cattle appears to be less severe and affected animals reach older ages (>9 years). A likely disease causing variant has been identified in Devon cattle: OMIA:001482-9913 : Neuronal ceroid lipofuscinosis, 5 in Bos taurus. [Imke Tammen: 21 Jan 2002]