Oligosaccharide content in milk
Phenotype Details
- Phene ID
- 4154
- Name
- Oligosaccharide content in milk
- Phene Name
- N/A
- OMIA ID
- 2170
- Species ID
- 9913
- Characterised
- No
- Characterised Year
- N/A
Genetic Test
Following a GWAS for "the abundance of 12 major OS [oligosaccharides] in milk of 360 cows, which had high density SNP marker genotypes", Liu et al. (2019) identified two variants of large effect: "a putative causal mutation close to the ABO gene on Chromosome 11 accounted for approximately 80% of genetic variance for two OS, N-acetylgalactosaminyllactose and lacto-N-neotetraose. This mutation lies very close to a variant associated with the expression levels of ABO. A third QTL mapped close to ST3GAL6 on Chromosome 1 explaining 33% of genetic variation of an abundant OS, 3'-sialyllactose."