Interdigital hyperplasia
Phenotype Details
- Phene ID
- 4252
- Name
- Interdigital hyperplasia
- Phene Name
- Bovine interdigital hyperplasia
- OMIA ID
- 2223
- Species ID
- 9913
- Characterised
- Yes
- Characterised Year
- 2019
Linked Variants
| Variant ID | Phenotype | Gene ID | Deleterious | Chromosome | Genomic | Transcript | Protein |
|---|---|---|---|---|---|---|---|
| 1139 | Interdigital hyperplasia | 388388719 | 1 | 8 | g.85905534T>A | c.25T>A | p.(W9R) |
Linked Breeds
| Breed | Breed ID | Species ID | VBO Term |
|---|---|---|---|
| Holstein (black and white) (Cattle) | 39 | 9913 | http://purl.obolibrary.org/obo/VBO_0000237 |
Inheritance
This disorder is multifactorial. As summarised by Zhang et al. (2019), "Bovine interdigital hyperplasia (IH) is a typical disease of the foot with varying prevalence depending on age, breed, and environmental factors resulting in different degrees of lameness. In studies based on assessments of claw health status at time of hoof trimming and applying genetic-statistical models to analyze this data, IH consistently exhibits high estimates of heritability in the range of 0.30–0.40."