Multidrug resistance 1, ABCB1-related

Phenotype Details
Phene ID
4463
Name
Multidrug resistance 1, ABCB1-related
Phene Name
N/A
OMIA ID
1402
Species ID
9913
Characterised
No
Characterised Year
N/A
Summary

Seaman et al. (1987) describe "an unusual nervous condition in Murray Grey cattle following treatment with avermectin B1 on a farm in the central tablelands of New South Wales. Eight cattle developed severe signs of central nervous system derangement and died or were euthanased. The neurological syndrome was reproduced in a field trial using avermectin B1. ... The greater than ten-fold concentrations of avermectin B1, detected in the brains of the affected cattle compared to the normal animal suggests an excessively high concentration of the drug in the nervous system of those affected cattle. ... The farm on which the reactions occurred has maintained a virtually closed herd for approximately 15 years. ... It is possible that the affected Murray Greys in this herd had some characteristics that allowed avermectin B, to penetrate the central nervous system more readily than would normally be expected."

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