Phenotypes
Polydactyly
Jacinto et al. (2025) investigated a crossbred animal with polydactyly. Whole genome seequencing analysis did not identify likely causal variants: "Analysis of the depth of coverage along all chromosomes revealed a partial monosomy of chromosome 28 at ~ 2.7 Mb from the chromosome end ... . ... The haploinsufficient region contains 39 annotated genes ... and hemizygosity for these genes may explain the observed phenotype."
Polymelia
Angus calves with polymelia (Denholm and Martin, 2011) were the first signs and are still a major component of a disorder now called Developmental Duplications (DD); see OMIA 002103-9913.
Polymicrogyria
No summary available.
Polyploidy, generic
No summary available.
Polyploidy, triploidy
No summary available.
Porencephaly, SLC25A12-related (inactive)
Paper under review
Porphyria, congenital erythropoietic — Pink tooth
Agerholm et al. (2012) sequenced the candidate gene UROS in affected and non-affected cattle, and identified a SNP in intron 8 that segregates with the disorder in all available cases. However, the authors concluded that analysis of more cases is required before a definite conclusion can be drawn about the causative mutation.
Portosystemic shunt
No summary available.
Preputial prolapse/eversion
No summary available.
Probatocephaly — Sheep's head
No summary available.
Prognathism
No summary available.
Progressive spinal myelopathy
No summary available.
Prolonged gestation
No summary available.
Protoporphyria — bovine erythropoietic protoporphyria
The report of the use of a DNA genotyping test by Healy et al. (1995), citing a personal communication from G.S. Johnson at the University of Missouri, implied that the molecular basis of this disorder within the gene for ferrochelatase had been determined by Dr Johnson. Jenkins et al. (1998) appear to have been the first to publicly report the molecular basis of this disorder. They did so by cloning and sequencing a very likely comparative ca...