Phenotypes
Thrombopathia, RASGRP2-related — Simmental hereditary thrombopathy; bleeding disorder;
On the strength of a clear candidate gene in which mutations cause the same disorder in dogs (OMIA 001003-9615), Boudreaux et al. (2007) reported that this disorder in a Simmental calf is due to a missense mutation (c.701T>C) in the CalDAG-GEFI gene which is now called RASGRP2. Jansen et al. (2013) reported that "Sanger sequencing confirmed that all thrombopathic animals are homozygous for the [same] pertinent amino acid exchange (c.701T &g...
Ticks, resistance/susceptibility to
No summary available.
Tomaculous neuropathy
The creation of this OMIA entry is based on information provided by PA Windsor, AE Kessell and JW Finnie
Tongue-wagging — Tongue play, Tongue rolling
Abnormal obsessive-compulsive behavior reported in German cattle as 'Zungenschlagen' [tongue wagging] or 'Zungenspielen' [tongue play] which can lead in extreme cases to malnutrition. Nutritional deficiencies and sub-optimal husbandry conditions are considered to contribute to aetiology and a genetic predisposition has been discussed by Bauer (1955).
Transmission ratio distortion
See also various other OMIA phenes called 'Haplotypes with homozygous deficiency' or 'Haplotype with homozygous deficiency, ...'
Tremor
No summary available.
Tricho-dento-osseous-like syndrome
In a remarkable indication of the power of modern genomic tools, Hofstetter et al. (2017) reported a novel form of curly coat in a single Brown Swiss calf, the offspring of two normal-coated parents. By whole-genome sequencing of the calf and its sire and dam, followed by informed interrogation of the sequence data (as described below), these authors were able to identify a likely causal variant in a gene which, when mutated in humans, gives r...
Trimethylaminuria (fishy taint)
In a neat piece of comparative detective work, Lunden et al. (2002; Genome Research 12:1885-1888) investigated whether the fishy off-flavour occasionally reported in cow's milk could be an animal model of fish-odor syndrome in humans, an inborn error of metabolism characterised by a fishy body odor, and known to be due to mutations in the gene for flavin-containing mono-oxygenase 3 (FMO3). They were able to show that this is, indeed, the case:...
Trypanosomiasis, susceptibility/resistance to
It has long been recognised that N'Dama (Bos taurus) cattle from west Africa are naturally trypanotolerant, in stark contrast to Bos indicus cattle such as the Kenyan Boran (reviewed by Murray et al., 1984). See detailed information in OMIA:001789-9903 : Trypanotolerance in Bos (oxen, cattle).
Tuberculosis, susceptibility/resistance to
This phene includes references to studies involving genetically modified organisms (GMO).
Twinning
see also: OMIA 001943-9913 : Fecundity, generic in Bos taurus
Twinning, conjoined
No summary available.
Urolithiasis
No summary available.
Uterine aplasia
No summary available.
Various disorders
No summary available.