| Identification |
|---|
| BMDB Protein ID
| BMDBP00002 |
| Secondary Accession Numbers
| None |
| Name
| Fatty acid desaturase 3 |
| Synonyms
|
Not Available
|
| Gene Name
| FADS3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Lipid transport and metabolism |
| Specific Function
| Acts as a methyl-end fatty acyl coenzyme A (CoA) desaturase that introduces a cis double bond between the preexisting double bond and the terminal methyl group of the fatty acyl chain. Desaturates (11E)-octadecenoate (trans-vaccenoate) at carbon 13 to generate (11E,13Z)-octadecadienoate, likely participating in the biohydrogenation pathway of linoleic acid (LA) (18:2n-6). |
| Pathways
|
- Lipid metabolism
- Polyunsaturated fatty acid biosynthesis
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 29 |
| Locus
| Not Available |
| SNPs
| FADS3 |
| Gene Sequence
|
>1332 bp
ATGGGCGGTGTCGGGGAGCCAGACTGGGAACCTGGGCAGCGGGGGGCGCCGCTGCCCACC
CTCCGCTGGGAGCAGGTCCGCCGGCACAACCTGCCAGGCGACAAGTGGCTGGTGATCGAG
CGTCGCGTCTACGACATCAGCCGCTGGGCACAGCGACACCCTGGGGGCAGCCGCCTCATC
GGCCACCACGGCGCCGAGGACGCCACGGATGCCTTCCACGCCTTCCACCAGGACCTCAGT
TTTGTGCGCAAGTTCCTGCAGCCTCTCCTGATTGGAGAGCTGGCCCCAGAGGAGCCCAGC
CAGGATGGACCCCAGAATACCCAGCTGATCGAGGACTTCCGAGCCCTGCGCCAGGCGGTG
GAGGACATGAAGCTGTTTGAAGCCAAGCCCGCCTTCTTCGGTCTCCTGCTGGGCCACATC
CTGGCCATGGAGGTGCTCGCCTGGCTCATGATCTACATGCTTGGCCCCGGCTGGGTGCCC
AGTACCCTGGCTGCCCTCATCCTGGCCATCTCCCAGGCCCAGAGTTGGTGTCTGCAGCAC
GACCTGGGCCACACGTCCATCTTCAGGAATTCCCGGTGGAACCACTTGGCCCAGCAGTTT
GTGATGGGGCAGCTGAAGGGCTTCTCTGCGCACTGGTGGAACTTCCGCCACTTCCAGCAC
CACGCCAAGCCCAACATCTTCCACAAGGACCCAGACGTGACTGTGGCGCCTGTCTTCCTT
TTGGGGGAGTCGTCCGTTGAGTACGGCAAGAAGAAGCGCAGATACTTGCCCTACAACCAC
CAGCACCTGTACTTCTTCCTGATCGGCCCGCCGCTGCTCACGCTGGTGAACTTCGAAGTG
GAAAATCTGGCCTACATGCTGGTGTGCATGCAGTGGATGGACTTGCTCTGGGCCGCCAGC
TTCTACGCCCGTTTCCTCTTGTCCTACATCCCCTTCTATGGCATTCCTGGGGCGCTGCTC
CTCTTTGTGGCTGTCAGGGTCCTGGAGAGCCACTGGTTTGTGTGGATCACACAGATGAAC
CATATCCCCAGGGAGATTGGCCATGAGAAGCACCGGGACTGGGCCAGCTCTCAGCTGGCA
GCCACCTGCAATGTGGAGCCCTCGCTCTTCATCGACTGGTTCAGCGGACACCTCAACTTC
CAGATCGAGCACCATCTCTTCCCCACGATGCCGAGGCACAACTATCGCAGGGTGGCCCCG
CTGGTCAAGGCCCTGTGTGCCAAGCATGGCCTCAGCTACGAGGTGAAGCCCTTCCTCACC
GCCCTGGTGGACATCATCAGGTCCCTGAAGAAGTCTGGCAATGTGTGGCTGGAAGCCTAC
CTCCACCAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 443 |
| Molecular Weight
| 51306.0 |
| Theoretical pI
| 8.37 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 131-151
- 153-173
- 260-280
- 283-303
- 305-325
|
| Protein Sequence
|
>Fatty acid desaturase 3
MGGVGEPDWEPGQRGAPLPTLRWEQVRRHNLPGDKWLVIERRVYDISRWAQRHPGGSRLI
GHHGAEDATDAFHAFHQDLSFVRKFLQPLLIGELAPEEPSQDGPQNTQLIEDFRALRQAV
EDMKLFEAKPAFFGLLLGHILAMEVLAWLMIYMLGPGWVPSTLAALILAISQAQSWCLQH
DLGHTSIFRNSRWNHLAQQFVMGQLKGFSAHWWNFRHFQHHAKPNIFHKDPDVTVAPVFL
LGESSVEYGKKKRRYLPYNHQHLYFFLIGPPLLTLVNFEVENLAYMLVCMQWMDLLWAAS
FYARFLLSYIPFYGIPGALLLFVAVRVLESHWFVWITQMNHIPREIGHEKHRDWASSQLA
ATCNVEPSLFIDWFSGHLNFQIEHHLFPTMPRHNYRRVAPLVKALCAKHGLSYEVKPFLT
ALVDIIRSLKKSGNVWLEAYLHQ
|
| External Links |
|---|
| GenBank ID Protein
| AAI34688.1 |
| UniProtKB/Swiss-Prot ID
| A4IFP3 |
| UniProtKB/Swiss-Prot Entry Name
| FADS3_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC134687 |
| GeneCard ID
| FADS3 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
