Showing Protein Aromatase (BMDBP00005)
| Identification | |||||
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| BMDB Protein ID | BMDBP00005 | ||||
| Secondary Accession Numbers |
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| Name | Aromatase | ||||
| Synonyms | Not Available | ||||
| Gene Name | CYP19A1 | ||||
| Protein Type | Enzyme | ||||
| Biological Properties | |||||
| General Function | Secondary metabolites biosynthesis, transport and catabolism | ||||
| Specific Function | A cytochrome P450 monooxygenase that catalyzes the conversion of C19 androgens, androst-4-ene-3,17-dione (androstenedione) and testosterone to the C18 estrogens, estrone and estradiol, respectively. Catalyzes three successive oxidations of C19 androgens: two conventional oxidations at C19 yielding 19-hydroxy and 19-oxo/19-aldehyde derivatives, followed by a third oxidative aromatization step that involves C1-beta hydrogen abstraction combined with cleavage of the C10-C19 bond to yield a phenolic A ring and formic acid. Alternatively, the third oxidative reaction yields a 19-norsteroid and formic acid. Converts dihydrotestosterone to delta1,10-dehydro 19-nordihydrotestosterone and may play a role in homeostasis of this potent androgen. Also displays 2-hydroxylase activity toward estrone. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). | ||||
| Pathways | Not Available | ||||
| Reactions |
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| GO Classification | Not Available | ||||
| Cellular Location | Not Available | ||||
| Gene Properties | |||||
| Chromosome Location | 10 | ||||
| Locus | 10q26 | ||||
| SNPs | CYP19A1 | ||||
| Gene Sequence |
>1512 bp ATGCTTTTGGAAGTGCTGAACCCAAGGCATTACAACGTCACCAGCATGGTGTCCGAAGTT GTGCCTATTGCCAGCATTGCAATCCTGCTGCTCACTGGATTTCTTCTCTTGGTTTGGAAT TATGAGGACACATCCTCAATACCAGGTCCCAGCTACTTTCTGGGAATTGGGCCCCTCATT TCCCACTGCAGGTTCCTCTGGATGGGGATCGGCAGTGCCTGCAATTACTACAACAAGATG TATGGAGAATTCATGAGAGTCTGGGTATGTGGAGAGGAAACCCTTATTATTAGCAAGTCC TCAAGTATGTTCCATGTAATGAAGCACAGTCACTACATATCCCGATTTGGCAGTAAACTT GGGTTGCAGTTCATCGGCATGCACGAGAAAGGCATCATATTTAACAATAATCCAGCACTC TGGAAAGCTGTTCGACCTTTCTTTACAAAAGCTTTGTCCGGCCCTGGCCTGGTGCGCATG GTGACCATCTGTGCTGATTCCATCACCAAGCATCTGGACAGGCTGGAGGAGGTCTGCAAT GACTTGGGCTATGTGGACGTGTTGACCCTCATGCGGCGCATCATGCTGGACACCTCTAAC ATGCTCTTCCTGGGGATCCCCTTGGATGAAAGTGCCATCGTGGTTAACATCCAGGGGTAT TTTGATGCATGGCAAGCTCTCCTTCTCAAACCAGACATCTTCTTTAAGATTTCTTGGCTG TGCAGAAAGTATGAAAAGTCTGTCAAGGACTTGAAAGATGCCATGGAAATTCTCATAGCA GAAAAAAGACACAGGATTTCAACAGCAGAGAAGCTGGAAGACAGCATAGATTTCGCCACT GAGTTGATTTTTGCTGAGAAACGTGGTGAACTTACAAGAGAGAATGTAAACCAGTGCATA TTGGAAATGCTGATCGCAGCGCCAGACACCATGTCTGTTTCTGTGTTCTTCATGCTGTTT CTTATTGCAAAGCATCCCCAGGTTGAAGAGGCAATAATAAGGGAAATCCAGACTGTTGTT GGTGAAAGAGACATAAGGATTGATGATATGCAAAAGCTAAAAGTGGTGGAAAACTTTATT AATGAGAGCATGCGGTACCAGCCCGTTGTGGACCTGGTCATGCGCAAAGCCTTAGAGGAT GATGTCATCGATGGCTACCCGGTGAAAAAGGGGACTAACATTATCCTGAATCTTGGAAGA ATGCATAGACTCGAGTTTTTCCCAAAGCCTAATGAGTTTACTCTTGAAAACTTTGCCAAG AATGTTCCTTACAGGTACTTTCAGCCATTTGGCTTTGGGCCCCGGGGCTGTGCGGGAAAG TACATCGCCATGGTGATGATGAAGGTCGTCCTGGTCACCCTTCTGAGACGCTTCCACGTG CAGACTTTGCAAGGTCGGTGCGTTGAGAAGATGCAGAAGAAAAATGACTTATCCTTGCAT CCAGACGAGACCAGAGACCGGCTAGAAATGATTTTCACCCCAAGAAATTCAGACAAGTGC CTCGAGCGCTAA |
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| Protein Properties | |||||
| Number of Residues | 503 | ||||
| Molecular Weight | 58090.0 | ||||
| Theoretical pI | 7.93 | ||||
| Pfam Domain Function | Not Available | ||||
| Signals |
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| Transmembrane Regions |
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| Protein Sequence |
>Cytochrome P450 19A1 MLLEVLNPRHYNVTSMVSEVVPIASIAILLLTGFLLLVWNYEDTSSIPGPSYFLGIGPLI SHCRFLWMGIGSACNYYNKMYGEFMRVWVCGEETLIISKSSSMFHVMKHSHYISRFGSKL GLQFIGMHEKGIIFNNNPALWKAVRPFFTKALSGPGLVRMVTICADSITKHLDRLEEVCN DLGYVDVLTLMRRIMLDTSNMLFLGIPLDESAIVVKIQGYFDAWQALLLKPDIFFKISWL CRKYEKSVKDLKDAMEILIEEKRHRISTAEKLEDSIDFATELIFAEKRGELTRENVNQCI LEMLIAAPDTMSVSVFFMLFLIAKHPQVEEAIIREIQTVVGERDIRIDDMQKLKVVENFI NESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNLGRMHRLEFFPKPNEFTLENFAK NVPYRYFQPFGFGPRACAGKYITMVMMKVVLVTLLRRFHVQTLQGRCVEKMQKKNDLSLH PDETRDRLEMIFTPRNSDKCLER |
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| External Links | |||||
| GenBank ID Protein | AAA62244.1 | ||||
| UniProtKB/Swiss-Prot ID | P46194 | ||||
| UniProtKB/Swiss-Prot Entry Name | CP19A_BOVIN | ||||
| PDB IDs | Not Available | ||||
| GenBank Gene ID | U18447 | ||||
| GeneCard ID | CYP19A1 | ||||
| GenAtlas ID | Not Available | ||||
| HGNC ID | Not Available | ||||
| References | |||||
| General References | Not Available | ||||