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| Identification |
|---|
| BMDB Protein ID
| BMDBP00005 |
| Secondary Accession Numbers
| |
| Name
| Aromatase |
| Synonyms
|
Not Available
|
| Gene Name
| CYP19A1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Secondary metabolites biosynthesis, transport and catabolism |
| Specific Function
| A cytochrome P450 monooxygenase that catalyzes the conversion of C19 androgens, androst-4-ene-3,17-dione (androstenedione) and testosterone to the C18 estrogens, estrone and estradiol, respectively. Catalyzes three successive oxidations of C19 androgens: two conventional oxidations at C19 yielding 19-hydroxy and 19-oxo/19-aldehyde derivatives, followed by a third oxidative aromatization step that involves C1-beta hydrogen abstraction combined with cleavage of the C10-C19 bond to yield a phenolic A ring and formic acid. Alternatively, the third oxidative reaction yields a 19-norsteroid and formic acid. Converts dihydrotestosterone to delta1,10-dehydro 19-nordihydrotestosterone and may play a role in homeostasis of this potent androgen. Also displays 2-hydroxylase activity toward estrone. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). |
| Pathways
|
Not Available
|
| Reactions
|
| 19-Oxotestosterone + Oxygen + Reduced flavoprotein → Estradiol + Formic acid + Oxidized flavoprotein |
details
|
| Androstenedione + Oxygen + Reduced flavoprotein → 19-Hydroxyandrost-4-ene-3,17-dione + Water + Oxidized flavoprotein |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 10 |
| Locus
| 10q26 |
| SNPs
| CYP19A1 |
| Gene Sequence
|
>1512 bp
ATGCTTTTGGAAGTGCTGAACCCAAGGCATTACAACGTCACCAGCATGGTGTCCGAAGTT
GTGCCTATTGCCAGCATTGCAATCCTGCTGCTCACTGGATTTCTTCTCTTGGTTTGGAAT
TATGAGGACACATCCTCAATACCAGGTCCCAGCTACTTTCTGGGAATTGGGCCCCTCATT
TCCCACTGCAGGTTCCTCTGGATGGGGATCGGCAGTGCCTGCAATTACTACAACAAGATG
TATGGAGAATTCATGAGAGTCTGGGTATGTGGAGAGGAAACCCTTATTATTAGCAAGTCC
TCAAGTATGTTCCATGTAATGAAGCACAGTCACTACATATCCCGATTTGGCAGTAAACTT
GGGTTGCAGTTCATCGGCATGCACGAGAAAGGCATCATATTTAACAATAATCCAGCACTC
TGGAAAGCTGTTCGACCTTTCTTTACAAAAGCTTTGTCCGGCCCTGGCCTGGTGCGCATG
GTGACCATCTGTGCTGATTCCATCACCAAGCATCTGGACAGGCTGGAGGAGGTCTGCAAT
GACTTGGGCTATGTGGACGTGTTGACCCTCATGCGGCGCATCATGCTGGACACCTCTAAC
ATGCTCTTCCTGGGGATCCCCTTGGATGAAAGTGCCATCGTGGTTAACATCCAGGGGTAT
TTTGATGCATGGCAAGCTCTCCTTCTCAAACCAGACATCTTCTTTAAGATTTCTTGGCTG
TGCAGAAAGTATGAAAAGTCTGTCAAGGACTTGAAAGATGCCATGGAAATTCTCATAGCA
GAAAAAAGACACAGGATTTCAACAGCAGAGAAGCTGGAAGACAGCATAGATTTCGCCACT
GAGTTGATTTTTGCTGAGAAACGTGGTGAACTTACAAGAGAGAATGTAAACCAGTGCATA
TTGGAAATGCTGATCGCAGCGCCAGACACCATGTCTGTTTCTGTGTTCTTCATGCTGTTT
CTTATTGCAAAGCATCCCCAGGTTGAAGAGGCAATAATAAGGGAAATCCAGACTGTTGTT
GGTGAAAGAGACATAAGGATTGATGATATGCAAAAGCTAAAAGTGGTGGAAAACTTTATT
AATGAGAGCATGCGGTACCAGCCCGTTGTGGACCTGGTCATGCGCAAAGCCTTAGAGGAT
GATGTCATCGATGGCTACCCGGTGAAAAAGGGGACTAACATTATCCTGAATCTTGGAAGA
ATGCATAGACTCGAGTTTTTCCCAAAGCCTAATGAGTTTACTCTTGAAAACTTTGCCAAG
AATGTTCCTTACAGGTACTTTCAGCCATTTGGCTTTGGGCCCCGGGGCTGTGCGGGAAAG
TACATCGCCATGGTGATGATGAAGGTCGTCCTGGTCACCCTTCTGAGACGCTTCCACGTG
CAGACTTTGCAAGGTCGGTGCGTTGAGAAGATGCAGAAGAAAAATGACTTATCCTTGCAT
CCAGACGAGACCAGAGACCGGCTAGAAATGATTTTCACCCCAAGAAATTCAGACAAGTGC
CTCGAGCGCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 503 |
| Molecular Weight
| 58090.0 |
| Theoretical pI
| 7.93 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Cytochrome P450 19A1
MLLEVLNPRHYNVTSMVSEVVPIASIAILLLTGFLLLVWNYEDTSSIPGPSYFLGIGPLI
SHCRFLWMGIGSACNYYNKMYGEFMRVWVCGEETLIISKSSSMFHVMKHSHYISRFGSKL
GLQFIGMHEKGIIFNNNPALWKAVRPFFTKALSGPGLVRMVTICADSITKHLDRLEEVCN
DLGYVDVLTLMRRIMLDTSNMLFLGIPLDESAIVVKIQGYFDAWQALLLKPDIFFKISWL
CRKYEKSVKDLKDAMEILIEEKRHRISTAEKLEDSIDFATELIFAEKRGELTRENVNQCI
LEMLIAAPDTMSVSVFFMLFLIAKHPQVEEAIIREIQTVVGERDIRIDDMQKLKVVENFI
NESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNLGRMHRLEFFPKPNEFTLENFAK
NVPYRYFQPFGFGPRACAGKYITMVMMKVVLVTLLRRFHVQTLQGRCVEKMQKKNDLSLH
PDETRDRLEMIFTPRNSDKCLER
|
| External Links |
|---|
| GenBank ID Protein
| AAA62244.1 |
| UniProtKB/Swiss-Prot ID
| P46194 |
| UniProtKB/Swiss-Prot Entry Name
| CP19A_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| U18447 |
| GeneCard ID
| CYP19A1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
