Showing Protein Cytochrome P450 11B1, mitochondrial (BMDBP00010)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 15 metabolites
Identification
BMDB Protein ID BMDBP00010
Secondary Accession Numbers
  • BMDBP03127
Name Cytochrome P450 11B1, mitochondrial
Synonyms Not Available
Gene Name CYP11B1
Protein Type Enzyme
Biological Properties
General Function Secondary metabolites biosynthesis, transport and catabolism
Specific Function A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids. Catalyzes the hydroxylation of carbon hydrogen bond at 11-beta position of 11-deoxycortisol and 11-deoxycorticosterone/21-hydroxyprogesterone yielding cortisol or corticosterone, respectively. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin).
Pathways Not Available
Reactions
Deoxycorticosterone + Oxygen + Reduced adrenal ferredoxin → Corticosterone + Water + Oxidized adrenal ferredoxin details
Progesterone + Oxygen + Reduced adrenal ferredoxin → 11b-Hydroxyprogesterone + Water + Oxidized adrenal ferredoxin details
17-Hydroxyprogesterone + Oxygen + Reduced adrenal ferredoxin → 21-Deoxycortisol + Water + Oxidized adrenal ferredoxin details
Cortexolone + Oxygen + Reduced adrenal ferredoxin → Cortisol + Water + Oxidized adrenal ferredoxin details
17a,21-Dihydroxypreg-nenolone + Oxygen + Reduced adrenal ferredoxin → 11b,17a,21-Trihydroxypreg-nenolone + Water + Oxidized adrenal ferredoxin details
GO Classification Not Available
Cellular Location Not Available
Gene Properties
Chromosome Location 14
Locus Not Available
SNPs CYP11B1
Gene Sequence 
>1512 bp
ATGGCACTGTGGGCAAAGGCCAGGGTGCGGATGGCAGGGCCCTGGCTGTCCCTGCATGAG
GCACGCCTACTGGGCACCAGAGGTGCTGTAGCCCCCAAGGCGGTGCTGCCCTTCGAAGCC
ATGCCCCGGTGTCCTGGCAACAAGTGGATGCGGATGCTGCAGATCTGGAAGGAGCAGGGT
TCTGAGAACATGCACTTGGACATGCATCAGACCTTCCAGGAGCTGGGGCCCATTTTCAGG
TACGACGTGGGAGGGAGACACATGGTGTTCGTGATGCTGCCCGAGGACGTGGAGAGGCTG
CAGCAGGCGGACAGCCGTCACCCTCAGCGGATGATCCTGGAGCCCTGGCTGGCCTACCGA
CAGGCTCGCGGGCACAAGTGTGGCGTGTTCTTGCTCAATGGGCCCCAGTGGCGTTTGGAC
CGACTGCGGCTGAACCCAGACGTCCTCTCGCTGCCAGCCCTGCAGAAGTACACGCCCTTG
GTGGATGGCGTGGCCAGGGACTTCTCCCAGACCCTGAAGGCGAGGGTGCTGCAGAATGCT
CGGGGGAGTCTGACCCTGGACATCGCGCCCAGCGTCTTCCGCTACACCATCGAAGCCAGC
ACCTTAGTCCTTTACGGGGAGCGGCTTGGCCTTTTGACCCAGCAACCAAACCCTGACAGC
CTGAACTTTATCCACGCGCTGGAGGCCATGTTGAAGTCCACCGTGCAGCTCATGTTTGTG
CCCAGGCGCCTGTCACGGTGGATGAGCACCAACATGTGGAGGGAGCACTTTGAGGCCTGG
GACTACATCTTCCAGTATGCCAACAGAGCCATCCAGAGAATCTATCAGGAGCTGGCCCTC
GGCCACCCGTGGCACTACAGCGGCATCGTGGCAGAGCTGCTGATGCGAGCAGACATGACC
CTGGATACCATCAAGGCCAACACGATCGACCTCACTGCTGGGAGTGTGGACACGACAGCC
TTCCCCTTGCTGATGACTCTCTTTGAGCTGGCTCGGAACCCGGAGGTGCAGCAGGCGGTG
CGCCAGGAGAGCCTGGTGGCTGAGGCCCGGATCTCAGAAAATCCCCAGAGGGCCATCACG
GAGCTGCCTTTGCTGCGGGCGGCCCTCAAGGAGACCTTGAGGCTGTACCCCGTGGGTATC
ACCTTGGAGCGGGAAGTGAGCTCGGACCTGGTGCTGCAGAACTACCACATCCCAGCTGGG
ACGCTGGTGAAGGTCCTACTCTATTCCCTGGGTCGAAACCCCGCCGTGTTCGCCAGGCCT
GAGAGCTATCACCCCCAGCGCTGGCTGGACCGCCAGGGCTCTGGAAGCAGATTCCCGCAC
CTGGCCTTTGGCTTTGGCGTACGCCAGTGCCTGGGGCGGCGCGTGGCCGAGGTGGAGATG
CTGCTCCTGCTGCACCATGTGCTGAAGAACTTCCTGGTGGAGACACTGGAGCAAGAGGAC
ATAAAGATGGTCTACCGCTTCATACTGATGCCCTCCACCCTGCCCCTCTTCACCTTCCGG
GCCATCCAGTAG
Protein Properties
Number of Residues 503
Molecular Weight 57847.0
Theoretical pI 9.73
Pfam Domain Function Not Available
Signals
  • None
Transmembrane Regions Not Available
Protein Sequence 
>Cytochrome P450 11B1, mitochondrial
MALWAKARVRMAGPWLSLHEARLLGTRGAAAPKAVLPFEAMPRCPGNKWMRMLQIWKEQS
SENMHLDMHQTFQELGPIFRYDVGGRHMVFVMLPEDVERLQQADSHHPQRMILEPWLAYR
QARGHKCGVFLLNGPQWRLDRLRLNPDVLSLPALQKYTPLVDGVARDFSQTLKARVLQNA
RGSLTLDIAPSVFRYTIEASTLVLYGERLGLLTQQPNPDSLNFIHALEAMLKSTVQLMFV
PRRLSRWMSTNMWREHFEAWDYIFQYANRAIQRIYQELALGHPWHYSGIVAELLMRADMT
LDTIKANTIDLTAGSVDTTAFPLLMTLFELARNPEVQQAVRQESLVAEARISENPQRAIT
ELPLLRAALKETLRLYPVGITLEREVSSDLVLQNYHIPAGTLVKVLLYSLGRNPAVFARP
ESYHPQRWLDRQGSGSRFPHLAFGFGVRQCLGRRVAEVEMLLLLHHVLKNFLVETLEQED
IKMVYRFILMPSTLPLFTFRAIQ
GenBank ID Protein BAA00127.1
UniProtKB/Swiss-Prot ID P15150
UniProtKB/Swiss-Prot Entry Name C11B1_BOVIN
PDB IDs Not Available
GenBank Gene ID D00185
GeneCard ID CYP11B1
GenAtlas ID Not Available
HGNC ID Not Available
References
General References Not Available