Showing Protein Tryptophan 2,3-dioxygenase (BMDBP00012)
| Identification | |||
|---|---|---|---|
| BMDB Protein ID | BMDBP00012 | ||
| Secondary Accession Numbers | None | ||
| Name | Tryptophan 2,3-dioxygenase | ||
| Synonyms | Not Available | ||
| Gene Name | TDO2 | ||
| Protein Type | Enzyme | ||
| Biological Properties | |||
| General Function | Amino acid transport and metabolism | ||
| Specific Function | Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. | ||
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| Reactions |
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| GO Classification | Not Available | ||
| Cellular Location | Not Available | ||
| Gene Properties | |||
| Chromosome Location | 17 | ||
| Locus | Not Available | ||
| SNPs | TDO2 | ||
| Gene Sequence |
>1221 bp ATGAGTGGGTGCCCCTTTTTAGGAAAGAGCTTTGGATATGCTTTTAAACCACTCTCTGCA CAAGGCAGTGAAGAAGACAAATCACAGGCCGGTGTGAACAGAGCCAGTAAAGGAGGACTT ATCTATGGGAACTACCTGCAATTGGAAAAAGTTTTGAATGCACAGGAGCTTCAAAGTGAA ATGAAAGGAAATAAAATCCACGATGAACATCTTTTTATCATAACTCATCAAGCTTATGAA CTCTGGTTTAAGCAGATCCTGTGGGAATTAGATTCTGTTCGTGAGATCTTTCAGAATGGC CATGTGAGGGATGAGAGGAACATGCTGAAGGTGATCACCCGAATGCACCGAGTGGTGGTG ATCCTCAAACTCTTGGTCCAGCAGTTTTCCGTCCTGGAGACCATGACAGCCTTGGACTTC AATGACTTCAGAGAGTACTTATCCCCGGCGTCCGGCTTCCAGAGTCTGCAGTTCCGCCTG TTAGAAAACAAGATAGGGGTTCTGCAGAGCTTGAGGGTCCCTTACAACAGAAGACACTAC CGCGACAACTTCAGAGGGAAAGACAACGAGCTTCTGCTGAAGTCCGAGCAAGAAAGGACG CTTCTGCAGCTGGTTGAGGCATGGCTGGAAAGAACCCCAGGTTTAGAGCCGCATGGATTT AACTTCTGGGGAAAGCTTGAAAAGAACATTGTCAAAGGTTTGGAAGAAGAATTCACAAAG ATTCAGGCTAAGGAAGAGTCAGAGGAAAAGGAGGAACAAATGGCTGAATTTCAGAAGCAG AAAGAGGTATTACTGTCCTTATTTGATGAGAAACGTCATGAGCATCTCCTTAGTAAAGGA GAAAGACGGCTATCGTACAAAGCACTTCAGGGGGCCTTGATGATATATTTTTACAGGGAA GAGCCCAGGTTCCAGGTCCCTTTCCAGCTGCTGACTTTCCTCATGGATGTGGACTCACTC ATGACCAAGTGGAGATATAACCACGTGTGCCTGGTGCACAGGATGCTCGGCAGCAAGGCG GGCACTGGCGGGTCCTCTGGGTACCAGTACCTGCGCTCCACCGTGAGTGACAGGTACAAA GTATTTGTAGATTTATTTAATCTCTCAACATATCTGGTTCCCCGACACTGGATTCCGAAG ATGAACCCAGTCATTCATAAGTTCCTTTACACGGCTGAATACTGTGACAGCTCTTACTTC AGCAGTGATGAATCAGATTAA |
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| Protein Properties | |||
| Number of Residues | 406 | ||
| Molecular Weight | 47708.0 | ||
| Theoretical pI | 7.76 | ||
| Pfam Domain Function | Not Available | ||
| Signals |
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| Transmembrane Regions | Not Available | ||
| Protein Sequence |
>Tryptophan 2,3-dioxygenase MSGCPFLGKSFGYAFKPLSAQGSEEDKSQAGVNRASKGGLIYGNYLQLEKVLNAQELQSE MKGNKIHDEHLFIITHQAYELWFKQILWELDSVREIFQNGHVRDERNMLKVITRMHRVVV ILKLLVQQFSVLETMTALDFNDFREYLSPASGFQSLQFRLLENKIGVLQSLRVPYNRRHY RDNFRGKDNELLLKSEQERTLLQLVEAWLERTPGLEPHGFNFWGKLEKNIVKGLEEEFTK IQAKEESEEKEEQMAEFQKQKEVLLSLFDEKRHEHLLSKGERRLSYKALQGALMIYFYRE EPRFQVPFQLLTFLMDVDSLMTKWRYNHVCLVHRMLGSKAGTGGSSGYQYLRSTVSDRYK VFVDLFNLSTYLVPRHWIPKMNPVIHKFLYTAEYCDSSYFSSDESD |
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| External Links | |||
| GenBank ID Protein | AAI12551.1 | ||
| UniProtKB/Swiss-Prot ID | Q2KIQ5 | ||
| UniProtKB/Swiss-Prot Entry Name | T23O_BOVIN | ||
| PDB IDs | Not Available | ||
| GenBank Gene ID | BC112550 | ||
| GeneCard ID | TDO2 | ||
| GenAtlas ID | Not Available | ||
| HGNC ID | Not Available | ||
| References | |||
| General References | Not Available | ||