Showing Protein Lanosterol 14-alpha demethylase (BMDBP00014)
| Identification | |||||
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| BMDB Protein ID | BMDBP00014 | ||||
| Secondary Accession Numbers |
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| Name | Lanosterol 14-alpha demethylase | ||||
| Synonyms | Not Available | ||||
| Gene Name | CYP51A1 | ||||
| Protein Type | Enzyme | ||||
| Biological Properties | |||||
| General Function | Secondary metabolites biosynthesis, transport and catabolism | ||||
| Specific Function | A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25-dihydrolanosterol likely through sequential oxidative conversion of 14-alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). | ||||
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| Reactions |
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| GO Classification | Not Available | ||||
| Cellular Location | Not Available | ||||
| Gene Properties | |||||
| Chromosome Location | 4 | ||||
| Locus | Not Available | ||||
| SNPs | CYP51A1 | ||||
| Gene Sequence |
>1509 bp ATGCTGGACTTACTGCAGGCGGGCGGGTCAGTGCTGGGGCAGGCGATGGAGCAAGTAACG GGCGGCAACCTCGCATCCATGCTGCTCATCGCCTGCGCCTTCACGCTTAGTCTGGTCTAC CTGTTCCGCCTCGCGGTTGGCCACCTGGCCCCACCACTGCCGACTGGGGCGAAAAGTCCA CCATACATTGTCTCTCCAATTCCATTCCTTGGACATGCTATAGCATTTGGGAAAAGTCCA ATTGAATTCCTAGAAGATGCATATGAGAAGTATGGACCTGTATTTAGTTTTACCATGGTG GGAAAGACGTTTACCTACCTGCTGGGGAGTGAGGCTGCTGCACTGCTTTTTAATAGTAAA AATGAAGACTTGAATGCCGAGGAAGTCTACAGTCGTCTGACGACACCTGTGTTTGGGAAG GGAGTTGCCTATGATGTGCCTAATACAGTTTTCTTGGAGCAGAAGAAAATGTTGAAAAGT GGTCTTAACATAGCCCACTTTAGACAGCACGTGTCTATAATTGAAAAAGAAACAAAAGAA TACTTTAAAAGTTGGGGAGAAAGTGGAGAAAAAAATTTGTTTGAAGCTCTTTCTGAGCTC ATCATTTTAACAGCCAGCCATTGTTTACATGGAAAGGAAATCAGAAGTCAACTCAACGAG AAGGTGGCACAACTGTATGCGGATTTGGATGGAGGTTTTAGCCATGCAGCCTGGCTTTTG CCAGGCTGGCTCCCTCTGCCTAGTTTCAGACGCAGGGACAGAGCTCATCGGGAGATCAAG AATATTTTCTACAAGGCAATCCAGAAACGCAGAGAGTCAGGAGAAAAAATTGATGACATT CTCCAAACTTTACTAGAGTCTACTTACAAGGATGGGCGTCCTCTGACGGATGATGAAGTA GCAGGCATGCTTATTGGACTGCTCTTGGCAGGGCAGCATACTTCTTCAACTACCAGTGCC TGGATGGGCTTCTTTTTGGCCAGAGACAAAACACTTCAAGAAAAATGTTTCTTAGAACAG AAAACAGTCTGTGGTGAGAATCTGCCTCCTCTGACTTATGACCAGCTCAAGGATCTCAAT TTACTTGATCGCTGTATAAAAGAAACATTAAGACTTCGACCTCCTATAATGACCATGATG AGACTGGCCAAAACTCCTCTGACTGTGGCAGGGTACACCATTCCTCCAGGACACCAGGTG TGTGTGTCTCCTACTGTCAATCAGAGACTTAAAGACTCATGGGTAGAGCGTCTGGACTTC AATCCTGACCGCTACTTAGAGGACAGCCCAGCATCAGGAGAGAAGTTTGCTTACGTGCCA TTTGGAGCTGGGCGTCATCGTTGCATTGGGGAGAATTTTGCCTATGTTCAAATCAAGACA ATTTGGTCCACTATGCTTCGTTTATATGAATTTGATCTCATTGATGGGTATTTTCCCACT GTGAATTATACAACTATGATTCACACCCCTGAAAAACCCATCATCAGATACAAACGAAGA TCAAAATGA |
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| Protein Properties | |||||
| Number of Residues | 502 | ||||
| Molecular Weight | 56596.0 | ||||
| Theoretical pI | 8.25 | ||||
| Pfam Domain Function | Not Available | ||||
| Signals |
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| Transmembrane Regions |
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| Protein Sequence |
>Lanosterol 14-alpha demethylase MLDLLQAGGSVLGQAMEQVTGGNLASMLLIACAFTLSLVYLFRLAVGHLAPPLPTGAKSP PYIVSPIPFLGHAIAFGKSPIEFLEDAYEKYGPVFSFTMVGKTFTYLLGSEAAALLFNSK NEDLNAEEVYSRLTTPVFGKGVAYDVPNTVFLEQKKMLKSGLNIAHFRQHVSIIEKETKE YFKSWGESGEKNLFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFSHAAWLL PGWLPLPSFRRRDRAHREIKNIFYKAIQKRRESGEKIDDILQTLLESTYKDGRPLTDDEV AGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQEKCFLEQKTVCGENLPPLTYDQLKDLN LLDRCIKETLRLRPPIMTMMRLAKTPLTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDF NPDRYLEDSPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDGYFPT VNYTTMIHTPEKPIIRYKRRSK |
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| External Links | |||||
| GenBank ID Protein | AAY82452.1 | ||||
| UniProtKB/Swiss-Prot ID | Q4PJW3 | ||||
| UniProtKB/Swiss-Prot Entry Name | CP51A_BOVIN | ||||
| PDB IDs | Not Available | ||||
| GenBank Gene ID | DQ078267 | ||||
| GeneCard ID | CYP51A1 | ||||
| GenAtlas ID | Not Available | ||||
| HGNC ID | Not Available | ||||
| References | |||||
| General References | Not Available | ||||