Showing Protein Prostaglandin G/H synthase 2 (BMDBP00044)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00044 |
| Secondary Accession Numbers | None |
| Name | Prostaglandin G/H synthase 2 |
| Synonyms | Not Available |
| Gene Name | PTGS2 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in heme binding |
| Specific Function | Dual cyclooxygenase and peroxidase in the biosynthesis pathway of prostanoids, a class of C20 oxylipins mainly derived from arachidonate, with a particular role in the inflammatory response. The cyclooxygenase activity oxygenates arachidonate (AA, C20:4(n-6)) to the hydroperoxy endoperoxide prostaglandin G2 (PGG2), and the peroxidase activity reduces PGG2 to the hydroxy endoperoxide PGH2, the precursor of all 2-series prostaglandins and thromboxanes. This complex transformation is initiated by abstraction of hydrogen at carbon 13 (with S-stereochemistry), followed by insertion of molecular O2 to form the endoperoxide bridge between carbon 9 and 11 that defines prostaglandins. The insertion of a second molecule of O2 (bis-oxygenase activity) yields a hydroperoxy group in PGG2 that is then reduced to PGH2 by two electrons. Similarly catalyzes successive cyclooxygenation and peroxidation of dihomo-gamma-linoleate (DGLA, C20:3(n-6)) and eicosapentaenoate (EPA, C20:5(n-3)) to corresponding PGH1 and PGH3, the precursors of 1- and 3-series prostaglandins. In an alternative pathway of prostanoid biosynthesis, converts 2-arachidonoyl lysophopholipids to prostanoid lysophopholipids, which are then hydrolyzed by intracellular phospholipases to release free prostanoids. Metabolizes 2-arachidonoyl glycerol yielding the glyceryl ester of PGH2, a process that can contribute to pain response. Generates lipid mediators from n-3 and n-6 polyunsaturated fatty acids (PUFAs) via a lipoxygenase-type mechanism. Oxygenates PUFAs to hydroperoxy compounds and then reduces them to corresponding alcohols. Plays a role in the generation of resolution phase interaction products (resolvins) during both sterile and infectious inflammation. Metabolizes docosahexaenoate (DHA, C22:6(n-3)) to 17R-HDHA, a precursor of the D-series resolvins (RvDs). As a component of the biosynthetic pathway of E-series resolvins (RvEs), converts eicosapentaenoate (EPA, C20:5(n-3)) primarily to 18S-HEPE that is further metabolized by ALOX5 and LTA4H to generate 18S-RvE1 and 18S-RvE2. In vascular endothelial cells, converts docosapentaenoate (DPA, C22:5(n-3)) to 13R-HDPA, a precursor for 13-series resolvins (RvTs) shown to activate macrophage phagocytosis during bacterial infection. In activated leukocytes, contributes to oxygenation of hydroxyeicosatetraenoates (HETE) to diHETES (5,15-diHETE and 5,11-diHETE) (By similarity). During neuroinflammation, plays a role in neuronal secretion of specialized preresolving mediators (SPMs) 15R-lipoxin A4 that regulates phagocytic microglia (By similarity). |
| Pathways |
|
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 16 |
| Locus | Not Available |
| SNPs | PTGS2 |
| Gene Sequence |
>1815 bp ATGCTCGCCCGGGCCCTGCTGCTCTGCGCTGCCGTGGCGCTCAGCGGTGCAGCAAATCCT TGCTGTTCCCATCCATGTCAGAATCGAGGTGTATGTATGAGTGTAGGATTTGACCAGTAT AAATGTGACTGTACCCGAACAGGATTCTACGGTGAAAACTGTACCACACCCGAATTTCTG ACAAGAATAAAATTACTCCTGAAACCCACTCCCAACACAGTGCACTACATACTTACCCAC TTCAAAGGAGTCTGGAACATTGTCAATAAGATCTCCTTCCTGCGAAATATGATTATGAGA TATGTGTTGACGTCGAGATCACATTTGATTGAGAGTCCACCAACTTATAATGTGCACTAC AGCTATAAAAGCTGGGAAGCCTTTTCTAACCTGTCTTATTATACCAGAGCTCTTCCTCCT GTGCCTGATGACTGCCCAACACCCATGGGTGTGAAAGGGAGGAAAGAGCTTCCTGATTCA AAAGAAGTTGTGAAAAAAGTACTTCTAAGAAGAAAGTTCATTCCTGATCCCCAGGGCACA AATCTGATGTTTGCATTCTTTGCCCAGCACTTCACCCATCAATTTTTCAAGACAGATTTT GAACGAGGACCAGCTTTCACTAAGGGAAAGAACCATGGGGTGGACTTAAGTCACATTTAT GGTGAATCTTTAGAGAGACAGCATAAGCTGCGCCTTTTCAAGGATGGAAAAATGAAATAT CAGATGATTAATGGAGAGATGTATCCTCCCACAGTCAAAGATACTCAGGTCGAAATGATC TACCCGCCTCATGTTCCTGAACACTTGAAGTTTGCTGTGGGCCAGGAAGTCTTTGGTCTG GTGCCTGGTCTGATGATGTATGCCACCATTTGGCTACGGGAACACAACAGAGTGTGTGAT GTGCTTAAACAAGAGCATCCAGAATGGGGCGATGAGCAGTTGTTCCAGACAAGCAGGCTA ATCCTGATAGGAGAAACTATTAAGATTGTGATTGAAGACTACGTACAGCACTTGAGTGGC TATCACTTCAAACTGAAGTTTGACCCAGAGCTGCTTTTCAACCAACAGTTCCAGTACCAG AACCGTATTGCTGCTGAGTTTAACACGCTCTACCACTGGCATCCCCTTCTGCCTGACGTC TTTCAGATTGATGGTCAGGAGTACAACTATCAGCAGTTTATCTATAACAACTCTGTCTTA CTGGAACATGGTCTCACTCAGTTTGTTGAATCATTCACCAGGCAAAGGGCTGGCAGGGTC GCTGGCGGTAGGAATCTTCCAGTCGCAGTAGAGAAAGTATCAAAGGCTTCAATTGACCAG AGCAGAGAGATGAAATACCAGTCTTTTAATGAGTATCGCAAACGTTTTCTCGTGAAGCCC TATGAATCATTTGAGGAACTTACAGGAGAGAAGGAAATGGCTGCAGAGTTAGAAGCGCTC TATGGAGACATAGATGCCATGGAGTTTTATCCCGCCCTTCTGGTAGAGAAGCCCCGTCCA GACGCCATCTTTGGGGAGACCATGGTAGAAGCTGGAGCACCATTCTCCCTGAAAGGACTT ATGGGTAATCCTATATGCTCTCCCGAGTACTGGAAGCCTAGCACTTTCGGTGGAGAAGTA GGTTTTAAAATCATCAACACTGCCTCAATTCAGTCTCTCATCTGCAGTAACGTGAAAGGC TGTCCCTTTACCTCATTCAGTGTTCAAGATACGCACCTCACCAAAACGGTCACCATTAAT GCAAGCTCTTCCCACTCTGGACTAGATGATATCAACCCCACAGTCCTACTAAAGGAACGT TCAACCGAACTGTAG |
| Protein Properties | |
| Number of Residues | 604 |
| Molecular Weight | 69163.0 |
| Theoretical pI | 7.59 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>Prostaglandin G/H synthase 2 MLARALLLCAAVALSGAANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCTTPEFL TRIKLLLKPTPNTVHYILTHFKGVWNIVNKISFLRNMIMRYVLTSRSHLIESPPTYNVHY SYKSWEAFSNLSYYTRALPPVPDDCPTPMGVKGRKELPDSKEVVKKVLLRRKFIPDPQGT NLMFAFFAQHFTHQFFKTDFERGPAFTKGKNHGVDLSHIYGESLERQHKLRLFKDGKMKY QMINGEMYPPTVKDTQVEMIYPPHVPEHLKFAVGQEVFGLVPGLMMYATIWLREHNRVCD VLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNQQFQYQ NRIAAEFNTLYHWHPLLPDVFQIDGQEYNYQQFIYNNSVLLEHGLTQFVESFTRQRAGRV AGGRNLPVAVEKVSKASIDQSREMKYQSFNEYRKRFLVKPYESFEELTGEKEMAAELEAL YGDIDAMEFYPALLVEKPRPDAIFGETMVEAGAPFSLKGLMGNPICSPEYWKPSTFGGEV GFKIINTASIQSLICSNVKGCPFTSFSVQDTHLTKTVTINASSSHSGLDDINPTVLLKER STEL |
| External Links | |
| GenBank ID Protein | AAC04702.1 |
| UniProtKB/Swiss-Prot ID | O62698 |
| UniProtKB/Swiss-Prot Entry Name | PGH2_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | AF031698 |
| GeneCard ID | PTGS2 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |