Showing Protein Prostaglandin G/H synthase 1 (BMDBP00046)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00046 |
| Secondary Accession Numbers |
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| Name | Prostaglandin G/H synthase 1 |
| Synonyms | Not Available |
| Gene Name | PTGS1 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in heme binding |
| Specific Function | Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells (By similarity). |
| Pathways |
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| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 11 |
| Locus | Not Available |
| SNPs | PTGS1 |
| Gene Sequence |
>1803 bp ATGAGCCGGCAGGGTATCTCGCTCCGATTCCCGCTGCTTCTCCTGCTGCTGTCGCCGTCC CCCGTCTTGCCAGCGGACCCCGGGGCGCCCGCGCCAGTGAACCCCTGCTGTTACTATCCA TGCCAGCACCAGGGGATCTGTGTTCGCTTCGGCCTTGACCGCTACCAATGTGACTGCACC CGCACGGGCTATTATGGCCCCAACTGCACCATCCCTGAGATATGGACCTGGCTCCGGACG ACTTTGCGGCCCAGCCCGTCTTTCGTCCACTTTCTGCTGACGCATGGGCGCTGGCTGTGG GATTTTGTCAATGCCACCTTCATCCGGGACAAGCTCATGCGTCTGGTACTCACAGTGCGT TCCAACCTTATCCCCAGCCCTCCCACCTACAACGTAGCGCATGACTACATCAGCTGGGAG TCCTTCTCCAATGTGAGTTATTATACTCGCATTCTGCCCTCCGTGCCCCGAGACTGTCCC ACGCCCATGGGCACCAAAGGGAAGAAGCAGTTGCCAGATGCGGAGTTTCTGAGTCGTCGC TTCCTGCTCAGGAGGAAGTTCATCCCCGACCCTCAAGGCACCAACCTCATGTTTGCCTTC TTTGCCCAACACTTCACCCATCAGTTCTTCAAAACTTCTGGCAAGATGGGTCCTGGCTTC ACCAAGGCGTTGGGCCACGGGGTAGACCTCGGCCACATTTATGGAGACAATCTGGAACGT CAGTATCAGCTGCGGCTCTTTAAGGATGGGAAACTCAAGTACCAGATGCTCAATGGAGAG GTGTACCCGCCATCGGTGGAAGAGGCTCCCGTGCTGATGCACTACCCCCGGGGCATCCCG CCCCAGAGCCAGATGGCCGTGGGCCAGGAGGTGTTTGGGCTGCTTCCTGGGCTCATGGTC TACGCCACGATATGGCTGCGTGAGCACAACCGCGTGTGTGACCTGCTGAAGGCTGAGCAC CCGACCTGGGGCGACGAGCAGCTCTTCCAGACGGCCCGCCTCATCCTCATCGGGGAGACC ATCAAGATTGTGATAGAGGAGTATGTGCAGCAGCTGAGCGGCTACTTCCTGCAGCTCAAG TTCGACCCAGAGCTGCTGTTTGGGGCCCAATTCCAGTACCGCAACCGCATCGCCATGGAG TTCAACCAGCTTTACCACTGGCACCCGCTCATGCCCGACTCCTTCCGGGTGGGCCCCCAG GACTACAGCTACGAGCAGTTTCTGTTCAACACCTCCATGCTGGTGGACTACGGGGTCGAG GCCCTGGTGGACGCCTTTTCTCGCCAGCCTGCAGGCCGGATCGGTGGGGGTAGGAACATA GACCACCACATCCTGCACGTGGCCGTGGATGTCATCAAGGAATCGCGGGAGCTGAGGCTG CAGCCTTTCAATGAGTACCGCAAGAGGTTTGGCATGAAGCCCTACACCTCTTTCCAGGAG CTCACAGGGGAGAAGGAGATGGCAGCTGAGTTGGAGGAGCTGTATGGAGACATCGATGCT TTGGAATTCTACCCGGGGCTACTTCTTGAGAAGTGCCATCCGAACTCCATCTTTGGGGAG AGTATGATAGAAATGGGGGCTCCTTTTTCCCTTAAGGGCCTCTTAGGGAACCCCATCTGT TCTCCAGAGTACTGGAAGGCAAGCACATTTGGTGGTGATGTGGGCTTCAACCTTGTCAAG ACGGCCACGCTGAAGAAGCTGGTTTGCCTCAACACCAAGACTTGTCCCTACGTCTCCTTC CATGTGCCAGACCCCCATCGGGAGGACAGGCCTGGGGTGGAGCGGCCACCCACAGAGCTC TGA |
| Protein Properties | |
| Number of Residues | 600 |
| Molecular Weight | 68805.0 |
| Theoretical pI | 7.56 |
| Pfam Domain Function | Not Available |
| Signals |
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| Transmembrane Regions | Not Available |
| Protein Sequence |
>Prostaglandin G/H synthase 1 MSRQGISLRFPLLLLLLSPSPVLPADPGAPAPVNPCCYYPCQHQGICVRFGLDRYQCDCT RTGYYGPNCTIPEIWTWLRTTLRPSPSFVHFLLTHGRWLWDFVNATFIRDKLMRLVLTVR SNLIPSPPTYNVAHDYISWESFSNVSYYTRILPSVPRDCPTPMGTKGKKQLPDAEFLSRR FLLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLER QYQLRLFKDGKLKYQMLNGEVYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMV YATIWLREHNRVCDLLKAEHPTWGDEQLFQTARLILIGETIKIVIEEYVQQLSGYFLQLK FDPELLFGAQFQYRNRIAMEFNQLYHWHPLMPDSFRVGPQDYSYEQFLFNTSMLVDYGVE ALVDAFSRQPAGRIGGGRNIDHHILHVAVDVIKESRELRLQPFNEYRKRFGMKPYTSFQE LTGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEMGAPFSLKGLLGNPIC SPEYWKASTFGGDVGFNLVKTATLKKLVCLNTKTCPYVSFHVPDPHREDRPGVERPPTEL |
| External Links | |
| GenBank ID Protein | AAI34518.1 |
| UniProtKB/Swiss-Prot ID | O62664 |
| UniProtKB/Swiss-Prot Entry Name | PGH1_BOVIN |
| PDB IDs | |
| GenBank Gene ID | BC134517 |
| GeneCard ID | PTGS1 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |