| Identification |
|---|
| BMDB Protein ID
| BMDBP00046 |
| Secondary Accession Numbers
| |
| Name
| Prostaglandin G/H synthase 1 |
| Synonyms
|
Not Available
|
| Gene Name
| PTGS1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in heme binding |
| Specific Function
| Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells (By similarity). |
| Pathways
|
- Lipid metabolism
- Prostaglandin biosynthesis
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 11 |
| Locus
| Not Available |
| SNPs
| PTGS1 |
| Gene Sequence
|
>1803 bp
ATGAGCCGGCAGGGTATCTCGCTCCGATTCCCGCTGCTTCTCCTGCTGCTGTCGCCGTCC
CCCGTCTTGCCAGCGGACCCCGGGGCGCCCGCGCCAGTGAACCCCTGCTGTTACTATCCA
TGCCAGCACCAGGGGATCTGTGTTCGCTTCGGCCTTGACCGCTACCAATGTGACTGCACC
CGCACGGGCTATTATGGCCCCAACTGCACCATCCCTGAGATATGGACCTGGCTCCGGACG
ACTTTGCGGCCCAGCCCGTCTTTCGTCCACTTTCTGCTGACGCATGGGCGCTGGCTGTGG
GATTTTGTCAATGCCACCTTCATCCGGGACAAGCTCATGCGTCTGGTACTCACAGTGCGT
TCCAACCTTATCCCCAGCCCTCCCACCTACAACGTAGCGCATGACTACATCAGCTGGGAG
TCCTTCTCCAATGTGAGTTATTATACTCGCATTCTGCCCTCCGTGCCCCGAGACTGTCCC
ACGCCCATGGGCACCAAAGGGAAGAAGCAGTTGCCAGATGCGGAGTTTCTGAGTCGTCGC
TTCCTGCTCAGGAGGAAGTTCATCCCCGACCCTCAAGGCACCAACCTCATGTTTGCCTTC
TTTGCCCAACACTTCACCCATCAGTTCTTCAAAACTTCTGGCAAGATGGGTCCTGGCTTC
ACCAAGGCGTTGGGCCACGGGGTAGACCTCGGCCACATTTATGGAGACAATCTGGAACGT
CAGTATCAGCTGCGGCTCTTTAAGGATGGGAAACTCAAGTACCAGATGCTCAATGGAGAG
GTGTACCCGCCATCGGTGGAAGAGGCTCCCGTGCTGATGCACTACCCCCGGGGCATCCCG
CCCCAGAGCCAGATGGCCGTGGGCCAGGAGGTGTTTGGGCTGCTTCCTGGGCTCATGGTC
TACGCCACGATATGGCTGCGTGAGCACAACCGCGTGTGTGACCTGCTGAAGGCTGAGCAC
CCGACCTGGGGCGACGAGCAGCTCTTCCAGACGGCCCGCCTCATCCTCATCGGGGAGACC
ATCAAGATTGTGATAGAGGAGTATGTGCAGCAGCTGAGCGGCTACTTCCTGCAGCTCAAG
TTCGACCCAGAGCTGCTGTTTGGGGCCCAATTCCAGTACCGCAACCGCATCGCCATGGAG
TTCAACCAGCTTTACCACTGGCACCCGCTCATGCCCGACTCCTTCCGGGTGGGCCCCCAG
GACTACAGCTACGAGCAGTTTCTGTTCAACACCTCCATGCTGGTGGACTACGGGGTCGAG
GCCCTGGTGGACGCCTTTTCTCGCCAGCCTGCAGGCCGGATCGGTGGGGGTAGGAACATA
GACCACCACATCCTGCACGTGGCCGTGGATGTCATCAAGGAATCGCGGGAGCTGAGGCTG
CAGCCTTTCAATGAGTACCGCAAGAGGTTTGGCATGAAGCCCTACACCTCTTTCCAGGAG
CTCACAGGGGAGAAGGAGATGGCAGCTGAGTTGGAGGAGCTGTATGGAGACATCGATGCT
TTGGAATTCTACCCGGGGCTACTTCTTGAGAAGTGCCATCCGAACTCCATCTTTGGGGAG
AGTATGATAGAAATGGGGGCTCCTTTTTCCCTTAAGGGCCTCTTAGGGAACCCCATCTGT
TCTCCAGAGTACTGGAAGGCAAGCACATTTGGTGGTGATGTGGGCTTCAACCTTGTCAAG
ACGGCCACGCTGAAGAAGCTGGTTTGCCTCAACACCAAGACTTGTCCCTACGTCTCCTTC
CATGTGCCAGACCCCCATCGGGAGGACAGGCCTGGGGTGGAGCGGCCACCCACAGAGCTC
TGA
|
| Protein Properties |
|---|
| Number of Residues
| 600 |
| Molecular Weight
| 68805.0 |
| Theoretical pI
| 7.56 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Prostaglandin G/H synthase 1
MSRQGISLRFPLLLLLLSPSPVLPADPGAPAPVNPCCYYPCQHQGICVRFGLDRYQCDCT
RTGYYGPNCTIPEIWTWLRTTLRPSPSFVHFLLTHGRWLWDFVNATFIRDKLMRLVLTVR
SNLIPSPPTYNVAHDYISWESFSNVSYYTRILPSVPRDCPTPMGTKGKKQLPDAEFLSRR
FLLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLER
QYQLRLFKDGKLKYQMLNGEVYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMV
YATIWLREHNRVCDLLKAEHPTWGDEQLFQTARLILIGETIKIVIEEYVQQLSGYFLQLK
FDPELLFGAQFQYRNRIAMEFNQLYHWHPLMPDSFRVGPQDYSYEQFLFNTSMLVDYGVE
ALVDAFSRQPAGRIGGGRNIDHHILHVAVDVIKESRELRLQPFNEYRKRFGMKPYTSFQE
LTGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEMGAPFSLKGLLGNPIC
SPEYWKASTFGGDVGFNLVKTATLKKLVCLNTKTCPYVSFHVPDPHREDRPGVERPPTEL
|
| External Links |
|---|
| GenBank ID Protein
| AAI34518.1 |
| UniProtKB/Swiss-Prot ID
| O62664 |
| UniProtKB/Swiss-Prot Entry Name
| PGH1_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BC134517 |
| GeneCard ID
| PTGS1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
