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Identification |
BMDB Protein ID
| BMDBP00062 |
Secondary Accession Numbers
| |
Name
| Cytochrome P450 2E1 |
Synonyms
|
Not Available
|
Gene Name
| CYP2E1 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Secondary metabolites biosynthesis, transport and catabolism |
Specific Function
| A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. |
Pathways
|
Not Available
|
Reactions
|
Arachidonic acid + Oxygen → 14,15-epoxy-5,8,11-eicosatrienoic acid + Water |
details
|
Arachidonic acid + Oxygen → 11,12-Epoxyeicosatrienoic acid + Water |
details
|
Arachidonic acid + Oxygen → 8,9-Epoxyeicosatrienoic acid + Water |
details
|
Arachidonic acid + Oxygen → 5,6-Epoxy-8,11,14-eicosatrienoic acid + Water |
details
|
Retinoic acid → all-trans-5,6-Epoxyretinoic acid |
details
|
|
GO Classification
|
Not Available
|
Cellular Location
|
Not Available
|
Gene Properties |
Chromosome Location
| 26 |
Locus
| Not Available |
SNPs
| CYP2E1 |
Gene Sequence
|
>1488 bp
ATGGCCGCCCTGGGCATCACGGTCGCCCTGCTGGTGTGGATGGCCACCCTGCTGTTCATC
TCCATCTGGAAGCACATCTACAGCAGCTGGAAACTGCCCCCTGGCCCTTTCCCACTGCCC
ATCATCGGGAATCTTTTACAGCTGGATATTAAGAACATTCCCAAATCCTTCACCAGGCTG
GCGGAGAGGTACGGGCCGGTGTTCACCCTGTACCTGGGCTCTCAGCGTGCCGTGGTCGTG
CATGGCTACAAGCCCGTGAAGGAGGTCCTGCTTGACTACAAGAACGAGTTTTCTGGCAGA
GGAGAAAACCCTGGGTTCCAGATGCACAAGAACAATGGGATCATTTTCAACAATGGATCA
ACCTGGCGGGACACCCGACGGTTCTCGTTGACCACCCTCCGTGACTTAGGGATGGGAAAA
CAGGGCAATGAGCAGCGGATCCAGAGGGAGGCCCACTTCCTGCTGGAGGTGCTCAGGAAG
ACCCAGGGCCAGCCCTTTGACCCCACGTTTGTCGTCGGCTTTGCACCTTACAATGTCATC
TCTGACATCCTCTTCCACAAACGCTTTGACTATAAAGATCAGACGAGCCTGAGGCTGATG
AGTCTGTTCAACGAGAACTTCTACCTGCTCAGCAGCCCCTGGATCCAGCTTTATAATAAT
TTCCCAGACTACCTACAGTACCTGCCTGGAAGCCATAGAAAGCTACTGAAAAATGTGTCT
GAAGTAAAAAGTTATGCTTTAGAAAGAGTGAAGGATCACCAGAAGTCCCTGGAACCCAGC
TGCCCCCGAGGCTTCTTGGACACCATGCTGATAGAAATGGCCAAGGAAAGACACAGTGTG
GACCCTATGTACACCTTGGAAAACATCGCTGTGACTGTGGCCGACCTGCTCTTTGCGGGG
ACAGAGACCACCAGCACCACCCTGCGATACGGGCTCCTGATTCTCATGAAATACCCGGAG
GTTGAAGAGAAACTTCATGAAGAAATTGACAGGGTGATTGGGCCAAGCCGAATCCCTGCC
GTCAAGGACAGGCTGGACATGCCCTACCTGGATGCTGTGGTACATGAGATTCAGCGATTC
ATCGACCTCCTTCCCTCCAATCTGCTCCACGAAGCAACCCAGGACACAGTGTTCAGAGGA
TATGTCATCCCCAAGGGCACAGTCGTAATTCCGACGCTGGACTCTGTCTTACACGATAGG
CAAGAGTTTCCTGAACCAGAGAAGTTTAAACCAGAGCACTTTCTGAATGAAAATGGAAAG
TTCAAGTACAGTGACCATTTTAAGGCGTTTTCTGCAGGAAAGCGGGTGTGTGTTGGAGAA
GGCCTGGCTCGCATGGAACTGTTCCTGCTCTTGGCCGCCATCCTGCAGCACTTTAACTTG
AAGTCACTTGTTGACCCCAAGGATATCGACCTCAGCCCCATTGCAATTGGGTTTGGCAAG
ATCCCGCCCCGTTACAAACTCTGTCTCATTCCCCGCTCAAAAGTGTGA
|
Protein Properties |
Number of Residues
| 495 |
Molecular Weight
| 56827.0 |
Theoretical pI
| 9.3 |
Pfam Domain Function
|
Not Available |
Signals
|
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>Cytochrome P450 2E1
MAALGITVALLVWMATLLFISIWKHIYSSWKLPPGPFPLPIIGNLLQLDIKNIPKSFTRL
AERYGPVFTLYLGSQRAVVVHGYKPVKEVLLDYKNEFSGRGENPGFQMHKNNGIIFNNGS
TWRDTRRFSLTTLRDLGMGKQGNEQRIQREAHFLLEVLRKTQGQPFDPTFVVGFAPYNVI
SDILFHKRFDYKDQTSLRLMSLFNENFYLLSSPWIQLYNNFPDYLQYLPGSHRKLLKNVS
EVKSYALERVKDHQKSLEPSCPRGFLDTMLIEMAKERHSVDPMYTLENIAVTVADLLFAG
TETTSTTLRYGLLILMKYPEVEEKLHEEIDRVIGPSRIPAVKDRLDMPYLDAVVHEIQRF
IDLLPSNLLHEATQDTVFRGYVIPKGTVVIPTLDSVLHDRQEFPEPEKFKPEHFLNENGK
FKYSDHFKAFSAGKRVCVGEGLARMELFLLLAAILQHFNLKSLVDPKDIDLSPIAIGFGK
IPPRYKLCLIPRSKV
|
External Links |
GenBank ID Protein
| CAA04948.1 |
UniProtKB/Swiss-Prot ID
| O18963 |
UniProtKB/Swiss-Prot Entry Name
| CP2E1_BOVIN |
PDB IDs
|
Not Available |
GenBank Gene ID
| AJ001715 |
GeneCard ID
| CYP2E1 |
GenAtlas ID
| Not Available |
HGNC ID
| Not Available |
References |
General References
| Not Available |