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| Identification |
|---|
| BMDB Protein ID
| BMDBP00062 |
| Secondary Accession Numbers
| |
| Name
| Cytochrome P450 2E1 |
| Synonyms
|
Not Available
|
| Gene Name
| CYP2E1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Secondary metabolites biosynthesis, transport and catabolism |
| Specific Function
| A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. |
| Pathways
|
Not Available
|
| Reactions
|
| Arachidonic acid + Oxygen → 14,15-epoxy-5,8,11-eicosatrienoic acid + Water |
details
|
| Arachidonic acid + Oxygen → 11,12-Epoxyeicosatrienoic acid + Water |
details
|
| Arachidonic acid + Oxygen → 8,9-Epoxyeicosatrienoic acid + Water |
details
|
| Arachidonic acid + Oxygen → 5,6-Epoxy-8,11,14-eicosatrienoic acid + Water |
details
|
| Retinoic acid → all-trans-5,6-Epoxyretinoic acid |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 26 |
| Locus
| Not Available |
| SNPs
| CYP2E1 |
| Gene Sequence
|
>1488 bp
ATGGCCGCCCTGGGCATCACGGTCGCCCTGCTGGTGTGGATGGCCACCCTGCTGTTCATC
TCCATCTGGAAGCACATCTACAGCAGCTGGAAACTGCCCCCTGGCCCTTTCCCACTGCCC
ATCATCGGGAATCTTTTACAGCTGGATATTAAGAACATTCCCAAATCCTTCACCAGGCTG
GCGGAGAGGTACGGGCCGGTGTTCACCCTGTACCTGGGCTCTCAGCGTGCCGTGGTCGTG
CATGGCTACAAGCCCGTGAAGGAGGTCCTGCTTGACTACAAGAACGAGTTTTCTGGCAGA
GGAGAAAACCCTGGGTTCCAGATGCACAAGAACAATGGGATCATTTTCAACAATGGATCA
ACCTGGCGGGACACCCGACGGTTCTCGTTGACCACCCTCCGTGACTTAGGGATGGGAAAA
CAGGGCAATGAGCAGCGGATCCAGAGGGAGGCCCACTTCCTGCTGGAGGTGCTCAGGAAG
ACCCAGGGCCAGCCCTTTGACCCCACGTTTGTCGTCGGCTTTGCACCTTACAATGTCATC
TCTGACATCCTCTTCCACAAACGCTTTGACTATAAAGATCAGACGAGCCTGAGGCTGATG
AGTCTGTTCAACGAGAACTTCTACCTGCTCAGCAGCCCCTGGATCCAGCTTTATAATAAT
TTCCCAGACTACCTACAGTACCTGCCTGGAAGCCATAGAAAGCTACTGAAAAATGTGTCT
GAAGTAAAAAGTTATGCTTTAGAAAGAGTGAAGGATCACCAGAAGTCCCTGGAACCCAGC
TGCCCCCGAGGCTTCTTGGACACCATGCTGATAGAAATGGCCAAGGAAAGACACAGTGTG
GACCCTATGTACACCTTGGAAAACATCGCTGTGACTGTGGCCGACCTGCTCTTTGCGGGG
ACAGAGACCACCAGCACCACCCTGCGATACGGGCTCCTGATTCTCATGAAATACCCGGAG
GTTGAAGAGAAACTTCATGAAGAAATTGACAGGGTGATTGGGCCAAGCCGAATCCCTGCC
GTCAAGGACAGGCTGGACATGCCCTACCTGGATGCTGTGGTACATGAGATTCAGCGATTC
ATCGACCTCCTTCCCTCCAATCTGCTCCACGAAGCAACCCAGGACACAGTGTTCAGAGGA
TATGTCATCCCCAAGGGCACAGTCGTAATTCCGACGCTGGACTCTGTCTTACACGATAGG
CAAGAGTTTCCTGAACCAGAGAAGTTTAAACCAGAGCACTTTCTGAATGAAAATGGAAAG
TTCAAGTACAGTGACCATTTTAAGGCGTTTTCTGCAGGAAAGCGGGTGTGTGTTGGAGAA
GGCCTGGCTCGCATGGAACTGTTCCTGCTCTTGGCCGCCATCCTGCAGCACTTTAACTTG
AAGTCACTTGTTGACCCCAAGGATATCGACCTCAGCCCCATTGCAATTGGGTTTGGCAAG
ATCCCGCCCCGTTACAAACTCTGTCTCATTCCCCGCTCAAAAGTGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 495 |
| Molecular Weight
| 56827.0 |
| Theoretical pI
| 9.3 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Cytochrome P450 2E1
MAALGITVALLVWMATLLFISIWKHIYSSWKLPPGPFPLPIIGNLLQLDIKNIPKSFTRL
AERYGPVFTLYLGSQRAVVVHGYKPVKEVLLDYKNEFSGRGENPGFQMHKNNGIIFNNGS
TWRDTRRFSLTTLRDLGMGKQGNEQRIQREAHFLLEVLRKTQGQPFDPTFVVGFAPYNVI
SDILFHKRFDYKDQTSLRLMSLFNENFYLLSSPWIQLYNNFPDYLQYLPGSHRKLLKNVS
EVKSYALERVKDHQKSLEPSCPRGFLDTMLIEMAKERHSVDPMYTLENIAVTVADLLFAG
TETTSTTLRYGLLILMKYPEVEEKLHEEIDRVIGPSRIPAVKDRLDMPYLDAVVHEIQRF
IDLLPSNLLHEATQDTVFRGYVIPKGTVVIPTLDSVLHDRQEFPEPEKFKPEHFLNENGK
FKYSDHFKAFSAGKRVCVGEGLARMELFLLLAAILQHFNLKSLVDPKDIDLSPIAIGFGK
IPPRYKLCLIPRSKV
|
| External Links |
|---|
| GenBank ID Protein
| CAA04948.1 |
| UniProtKB/Swiss-Prot ID
| O18963 |
| UniProtKB/Swiss-Prot Entry Name
| CP2E1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AJ001715 |
| GeneCard ID
| CYP2E1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
