Showing Protein Cytochrome P450 2E1 (BMDBP00062)
| Identification | |||||||||||
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| BMDB Protein ID | BMDBP00062 | ||||||||||
| Secondary Accession Numbers |
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| Name | Cytochrome P450 2E1 | ||||||||||
| Synonyms | Not Available | ||||||||||
| Gene Name | CYP2E1 | ||||||||||
| Protein Type | Enzyme | ||||||||||
| Biological Properties | |||||||||||
| General Function | Secondary metabolites biosynthesis, transport and catabolism | ||||||||||
| Specific Function | A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. | ||||||||||
| Pathways | Not Available | ||||||||||
| Reactions |
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| GO Classification | Not Available | ||||||||||
| Cellular Location | Not Available | ||||||||||
| Gene Properties | |||||||||||
| Chromosome Location | 26 | ||||||||||
| Locus | Not Available | ||||||||||
| SNPs | CYP2E1 | ||||||||||
| Gene Sequence |
>1488 bp ATGGCCGCCCTGGGCATCACGGTCGCCCTGCTGGTGTGGATGGCCACCCTGCTGTTCATC TCCATCTGGAAGCACATCTACAGCAGCTGGAAACTGCCCCCTGGCCCTTTCCCACTGCCC ATCATCGGGAATCTTTTACAGCTGGATATTAAGAACATTCCCAAATCCTTCACCAGGCTG GCGGAGAGGTACGGGCCGGTGTTCACCCTGTACCTGGGCTCTCAGCGTGCCGTGGTCGTG CATGGCTACAAGCCCGTGAAGGAGGTCCTGCTTGACTACAAGAACGAGTTTTCTGGCAGA GGAGAAAACCCTGGGTTCCAGATGCACAAGAACAATGGGATCATTTTCAACAATGGATCA ACCTGGCGGGACACCCGACGGTTCTCGTTGACCACCCTCCGTGACTTAGGGATGGGAAAA CAGGGCAATGAGCAGCGGATCCAGAGGGAGGCCCACTTCCTGCTGGAGGTGCTCAGGAAG ACCCAGGGCCAGCCCTTTGACCCCACGTTTGTCGTCGGCTTTGCACCTTACAATGTCATC TCTGACATCCTCTTCCACAAACGCTTTGACTATAAAGATCAGACGAGCCTGAGGCTGATG AGTCTGTTCAACGAGAACTTCTACCTGCTCAGCAGCCCCTGGATCCAGCTTTATAATAAT TTCCCAGACTACCTACAGTACCTGCCTGGAAGCCATAGAAAGCTACTGAAAAATGTGTCT GAAGTAAAAAGTTATGCTTTAGAAAGAGTGAAGGATCACCAGAAGTCCCTGGAACCCAGC TGCCCCCGAGGCTTCTTGGACACCATGCTGATAGAAATGGCCAAGGAAAGACACAGTGTG GACCCTATGTACACCTTGGAAAACATCGCTGTGACTGTGGCCGACCTGCTCTTTGCGGGG ACAGAGACCACCAGCACCACCCTGCGATACGGGCTCCTGATTCTCATGAAATACCCGGAG GTTGAAGAGAAACTTCATGAAGAAATTGACAGGGTGATTGGGCCAAGCCGAATCCCTGCC GTCAAGGACAGGCTGGACATGCCCTACCTGGATGCTGTGGTACATGAGATTCAGCGATTC ATCGACCTCCTTCCCTCCAATCTGCTCCACGAAGCAACCCAGGACACAGTGTTCAGAGGA TATGTCATCCCCAAGGGCACAGTCGTAATTCCGACGCTGGACTCTGTCTTACACGATAGG CAAGAGTTTCCTGAACCAGAGAAGTTTAAACCAGAGCACTTTCTGAATGAAAATGGAAAG TTCAAGTACAGTGACCATTTTAAGGCGTTTTCTGCAGGAAAGCGGGTGTGTGTTGGAGAA GGCCTGGCTCGCATGGAACTGTTCCTGCTCTTGGCCGCCATCCTGCAGCACTTTAACTTG AAGTCACTTGTTGACCCCAAGGATATCGACCTCAGCCCCATTGCAATTGGGTTTGGCAAG ATCCCGCCCCGTTACAAACTCTGTCTCATTCCCCGCTCAAAAGTGTGA |
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| Protein Properties | |||||||||||
| Number of Residues | 495 | ||||||||||
| Molecular Weight | 56827.0 | ||||||||||
| Theoretical pI | 9.3 | ||||||||||
| Pfam Domain Function | Not Available | ||||||||||
| Signals |
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| Transmembrane Regions | Not Available | ||||||||||
| Protein Sequence |
>Cytochrome P450 2E1 MAALGITVALLVWMATLLFISIWKHIYSSWKLPPGPFPLPIIGNLLQLDIKNIPKSFTRL AERYGPVFTLYLGSQRAVVVHGYKPVKEVLLDYKNEFSGRGENPGFQMHKNNGIIFNNGS TWRDTRRFSLTTLRDLGMGKQGNEQRIQREAHFLLEVLRKTQGQPFDPTFVVGFAPYNVI SDILFHKRFDYKDQTSLRLMSLFNENFYLLSSPWIQLYNNFPDYLQYLPGSHRKLLKNVS EVKSYALERVKDHQKSLEPSCPRGFLDTMLIEMAKERHSVDPMYTLENIAVTVADLLFAG TETTSTTLRYGLLILMKYPEVEEKLHEEIDRVIGPSRIPAVKDRLDMPYLDAVVHEIQRF IDLLPSNLLHEATQDTVFRGYVIPKGTVVIPTLDSVLHDRQEFPEPEKFKPEHFLNENGK FKYSDHFKAFSAGKRVCVGEGLARMELFLLLAAILQHFNLKSLVDPKDIDLSPIAIGFGK IPPRYKLCLIPRSKV |
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| External Links | |||||||||||
| GenBank ID Protein | CAA04948.1 | ||||||||||
| UniProtKB/Swiss-Prot ID | O18963 | ||||||||||
| UniProtKB/Swiss-Prot Entry Name | CP2E1_BOVIN | ||||||||||
| PDB IDs | Not Available | ||||||||||
| GenBank Gene ID | AJ001715 | ||||||||||
| GeneCard ID | CYP2E1 | ||||||||||
| GenAtlas ID | Not Available | ||||||||||
| HGNC ID | Not Available | ||||||||||
| References | |||||||||||
| General References | Not Available | ||||||||||