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Showing Protein 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 (BMDBP00073)
Identification | |
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BMDB Protein ID | BMDBP00073 |
Secondary Accession Numbers | None |
Name | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 |
Synonyms | Not Available |
Gene Name | PLCD4 |
Protein Type | Enzyme |
Biological Properties | |
General Function | Involved in calcium ion binding |
Specific Function | Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation (By similarity). |
Pathways | Not Available |
Reactions | Not Available |
GO Classification | Not Available |
Cellular Location | Not Available |
Gene Properties | |
Chromosome Location | 2 |
Locus | Not Available |
SNPs | PLCD4 |
Gene Sequence |
>2376 bp ATGGCGTATCTGCTGCAAGGCCGGCTGCCCATCAATCAAGATCTGCTGCTGATGCAGAAA GGCACAATGATGCGCAAGGTGAGGTCCAAAAGCTGGAAGAAGCTAAGATTCTTCAGACTT CAGGACGATGGCATGACAGTCTGGCATGCCCGGCAGGCTGGAGGCAGGGCCAAGCCCAGC TTCTCAATCTCCGACGTGGACACAGTACGTGAGGACCACGAGTCTGAGTTGCTGCGCAAC CTGGCAGAGGAGTTCCCCCTGGAGCAGGGCTTCACCATCGTCTTCCATGGCCGCCGCTCC AACCTGGACCTGGTGGCCAACAGTGTCCAGGAAGCCCAGACCTGGATGCAGGGGCTCCAG CTGTTGGTGGGCTTTGTCACCAACATGGACCAACAGGAGAGGCTGGATCAATGGCTGAGT GATTGGTTCCAGCGCGGAGACAAAAACCAGGATGGTCGGATGAGTTTCGGAGAGGTCCAA CGGTTATTGCACCTGATGAATGTGGAAATGGACCAGGAATATGCCTTTCAGCTTTTCCAG ACAGCAGACACATCCCAGTCTGGGACTCTGGAGGGAGAAGAATTTGTAGAGTTCTATAAG TCATTGACTCAGCGTCCAGAAGTGCAGGAACTGTTTGAAAAGTTTTCATCTGATGGGCAG AAACTGACCCTGTTGGAATTTGTGGATTTCCTCCAAGAGGAACAGAAGGAAGGAGAACGG GCTTCTGACCTTGCTCTGGAACTCATCGACCGCTATGAGCCTTCAGAAAGTGGAAAACTG CGGCATGTGCTGAGCATGGATGGCTTCCTCGGCTACCTCTGCTCGAAGGACGGAGACATC TTCAATCCAACCTGCCACCCCCTCTACCAGGACATGACTCAACCCCTGAACCACTACTAC ATCAACTCCTCCCACAACACCTACCTGGTGGGGGACCAGCTTTGTGGCCAGAGCAGCGTG GAGGGATACATACGGGCCCTGAAGCGGGGGTGCCGCTGTGTGGAGGTGGATATATGGGAT GGACCAAGCGGGGAACCTATTGTTTACCACGGACACACCCTGACCTCCCGCATCCCATTC AAAGATGTTGTGGCCGCTATAGGACAGTATGCCTTCCAGACGTCAGACTATCCAGTCATC TTGTCGCTGGAGAACCACTGCAGCTGGGAGCAGCAGGAGATCATCGTGCGCCATCTGACG GAGATCCTGGGGGATCAGCTACTGACGACAGCCTTGGATGGGCAGCCTCCCACTCAGCTG CCCTCCCCCGAGGACCTTCGGGGGAAGATCCTTGTGAAGGGGAAGAAGCTAATGCTTGAG GAAGAGGAGGAAGAACCAGAGGCTGAATTGGAAGCAGAGCAGGAGGCTAGGCTGGACTTG GAGGCCCAGCTGGAGTCTGAGCCCCAGGACCTGAGCCCTCGCAGTGAGGACAAAAAGAAG GTTGTGATGTGCCCGCTGTTGTGTCGGCCTTTGTGTTGTCAGATTATGGCCCAGGCTCCT ATTTCCAAGCCTGGGCTTCTTCTCTTTCCCAAGCAGAAACCCAAGGCCATCTTGTGTCCA GCCCTCTCTGCCCTGGTTGTCTACTTGAAGGCTGTCACATTCTATAGCTTCACTCACTCG AGGGAGCACTACCACTTCTATGAAACATCATCTTTCTCTGAAACCAAGGCCAAGAGCCTC ATCAAGGAGGCTGGTGACGAGTTTGTGCAGCACAATGCCTGGCAGTTAAGCAGAGTGTAT CCCAGTGGCCTGAGGACGGATTCATCCAACTACAACCCCCAGGAATTCTGGAATGCAGGC TGCCAGATGGTGGCTATGAACATGCAGACAGCCGGGCTGGAGATGGACCTGTGTGATGGG CTCTTCCGCCAGAACGCTGGCTGTGGCTATGTGCTGAAGCCAGACTTCCTGCGCGATGCC CAGAGTTCCTTCCACCCTGAGAGGCCCATCAGCCCTTTCAAAGCCCAGACCCTCATCATC CAGGTAATCAGTGGTCAGCAACTCCCCAAAGTGGACAACACCAAAGAACAGTCCATTGTG GACCCCTTGGTGAGAGTGGAGATCTTTGGCGTCCGCCCAGACACAACCCGGCAAGAGACC AGCTACGTGGAGAACAATGGTTTTAATCCATACTGGGGGCAGACACTGTGCTTCCGGATC CTGGTACCTGAACTGGCCCTGCTGCGTTTTGTGGTCAAAGACTATGACTGGAAATCCCGA AACGACTTCATTGGTCAGTACACCCTGCCGTGGAGCTGCATGCAGCAAGGTTACCGCCAC ATACACCTGCTCTCCAAGGATGGCCTCAGCCTTCACCCAGCTTCCATCTTTGTGCACATC TGCACACAGGAAGTGTCAGAGGAGGCTGAATCTTAA |
Protein Properties | |
Number of Residues | 791 |
Molecular Weight | 90581.0 |
Theoretical pI | 4.89 |
Pfam Domain Function | Not Available |
Signals |
|
Transmembrane Regions | Not Available |
Protein Sequence |
>1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-4 MAYLLQGRLPINQDLLLMQKGTMMRKVRSKSWKKLRFFRLQDDGMTVWHARQAGGRAKPS FSISDVDTVREDHESELLRNLAEEFPLEQGFTIVFHGRRSNLDLVANSVQEAQTWMQGLQ LLVGFVTNMDQQERLDQWLSDWFQRGDKNQDGRMSFGEVQRLLHLMNVEMDQEYAFQLFQ TADTSQSGTLEGEEFVEFYKSLTQRPEVQELFEKFSSDGQKLTLLEFVDFLQEEQKEGER ASDLALELIDRYEPSESGKLRHVLSMDGFLGYLCSKDGDIFNPTCHPLYQDMTQPLNHYY INSSHNTYLVGDQLCGQSSVEGYIRALKRGCRCVEVDIWDGPSGEPIVYHGHTLTSRIPF KDVVAAIGQYAFQTSDYPVILSLENHCSWEQQEIIVRHLTEILGDQLLTTALDGQPPTQL PSPEDLRGKILVKGKKLMLEEEEEEPEAELEAEQEARLDLEAQLESEPQDLSPRSEDKKK VVMCPLLCRPLCCQIMAQAPISKPGLLLFPKQKPKAILCPALSALVVYLKAVTFYSFTHS REHYHFYETSSFSETKAKSLIKEAGDEFVQHNAWQLSRVYPSGLRTDSSNYNPQEFWNAG CQMVAMNMQTAGLEMDLCDGLFRQNAGCGYVLKPDFLRDAQSSFHPERPISPFKAQTLII QVISGQQLPKVDNTKEQSIVDPLVRVEIFGVRPDTTRQETSYVENNGFNPYWGQTLCFRI LVPELALLRFVVKDYDWKSRNDFIGQYTLPWSCMQQGYRHIHLLSKDGLSLHPASIFVHI CTQEVSEEAES |
External Links | |
GenBank ID Protein | AAI12450.1 |
UniProtKB/Swiss-Prot ID | P21671 |
UniProtKB/Swiss-Prot Entry Name | PLCD4_BOVIN |
PDB IDs | Not Available |
GenBank Gene ID | BC112449 |
GeneCard ID | PLCD4 |
GenAtlas ID | Not Available |
HGNC ID | Not Available |
References | |
General References | Not Available |