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Showing Protein 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 (BMDBP00073)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00073 |
| Secondary Accession Numbers | None |
| Name | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 |
| Synonyms | Not Available |
| Gene Name | PLCD4 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in calcium ion binding |
| Specific Function | Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation (By similarity). |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 2 |
| Locus | Not Available |
| SNPs | PLCD4 |
| Gene Sequence |
>2376 bp ATGGCGTATCTGCTGCAAGGCCGGCTGCCCATCAATCAAGATCTGCTGCTGATGCAGAAA GGCACAATGATGCGCAAGGTGAGGTCCAAAAGCTGGAAGAAGCTAAGATTCTTCAGACTT CAGGACGATGGCATGACAGTCTGGCATGCCCGGCAGGCTGGAGGCAGGGCCAAGCCCAGC TTCTCAATCTCCGACGTGGACACAGTACGTGAGGACCACGAGTCTGAGTTGCTGCGCAAC CTGGCAGAGGAGTTCCCCCTGGAGCAGGGCTTCACCATCGTCTTCCATGGCCGCCGCTCC AACCTGGACCTGGTGGCCAACAGTGTCCAGGAAGCCCAGACCTGGATGCAGGGGCTCCAG CTGTTGGTGGGCTTTGTCACCAACATGGACCAACAGGAGAGGCTGGATCAATGGCTGAGT GATTGGTTCCAGCGCGGAGACAAAAACCAGGATGGTCGGATGAGTTTCGGAGAGGTCCAA CGGTTATTGCACCTGATGAATGTGGAAATGGACCAGGAATATGCCTTTCAGCTTTTCCAG ACAGCAGACACATCCCAGTCTGGGACTCTGGAGGGAGAAGAATTTGTAGAGTTCTATAAG TCATTGACTCAGCGTCCAGAAGTGCAGGAACTGTTTGAAAAGTTTTCATCTGATGGGCAG AAACTGACCCTGTTGGAATTTGTGGATTTCCTCCAAGAGGAACAGAAGGAAGGAGAACGG GCTTCTGACCTTGCTCTGGAACTCATCGACCGCTATGAGCCTTCAGAAAGTGGAAAACTG CGGCATGTGCTGAGCATGGATGGCTTCCTCGGCTACCTCTGCTCGAAGGACGGAGACATC TTCAATCCAACCTGCCACCCCCTCTACCAGGACATGACTCAACCCCTGAACCACTACTAC ATCAACTCCTCCCACAACACCTACCTGGTGGGGGACCAGCTTTGTGGCCAGAGCAGCGTG GAGGGATACATACGGGCCCTGAAGCGGGGGTGCCGCTGTGTGGAGGTGGATATATGGGAT GGACCAAGCGGGGAACCTATTGTTTACCACGGACACACCCTGACCTCCCGCATCCCATTC AAAGATGTTGTGGCCGCTATAGGACAGTATGCCTTCCAGACGTCAGACTATCCAGTCATC TTGTCGCTGGAGAACCACTGCAGCTGGGAGCAGCAGGAGATCATCGTGCGCCATCTGACG GAGATCCTGGGGGATCAGCTACTGACGACAGCCTTGGATGGGCAGCCTCCCACTCAGCTG CCCTCCCCCGAGGACCTTCGGGGGAAGATCCTTGTGAAGGGGAAGAAGCTAATGCTTGAG GAAGAGGAGGAAGAACCAGAGGCTGAATTGGAAGCAGAGCAGGAGGCTAGGCTGGACTTG GAGGCCCAGCTGGAGTCTGAGCCCCAGGACCTGAGCCCTCGCAGTGAGGACAAAAAGAAG GTTGTGATGTGCCCGCTGTTGTGTCGGCCTTTGTGTTGTCAGATTATGGCCCAGGCTCCT ATTTCCAAGCCTGGGCTTCTTCTCTTTCCCAAGCAGAAACCCAAGGCCATCTTGTGTCCA GCCCTCTCTGCCCTGGTTGTCTACTTGAAGGCTGTCACATTCTATAGCTTCACTCACTCG AGGGAGCACTACCACTTCTATGAAACATCATCTTTCTCTGAAACCAAGGCCAAGAGCCTC ATCAAGGAGGCTGGTGACGAGTTTGTGCAGCACAATGCCTGGCAGTTAAGCAGAGTGTAT CCCAGTGGCCTGAGGACGGATTCATCCAACTACAACCCCCAGGAATTCTGGAATGCAGGC TGCCAGATGGTGGCTATGAACATGCAGACAGCCGGGCTGGAGATGGACCTGTGTGATGGG CTCTTCCGCCAGAACGCTGGCTGTGGCTATGTGCTGAAGCCAGACTTCCTGCGCGATGCC CAGAGTTCCTTCCACCCTGAGAGGCCCATCAGCCCTTTCAAAGCCCAGACCCTCATCATC CAGGTAATCAGTGGTCAGCAACTCCCCAAAGTGGACAACACCAAAGAACAGTCCATTGTG GACCCCTTGGTGAGAGTGGAGATCTTTGGCGTCCGCCCAGACACAACCCGGCAAGAGACC AGCTACGTGGAGAACAATGGTTTTAATCCATACTGGGGGCAGACACTGTGCTTCCGGATC CTGGTACCTGAACTGGCCCTGCTGCGTTTTGTGGTCAAAGACTATGACTGGAAATCCCGA AACGACTTCATTGGTCAGTACACCCTGCCGTGGAGCTGCATGCAGCAAGGTTACCGCCAC ATACACCTGCTCTCCAAGGATGGCCTCAGCCTTCACCCAGCTTCCATCTTTGTGCACATC TGCACACAGGAAGTGTCAGAGGAGGCTGAATCTTAA |
| Protein Properties | |
| Number of Residues | 791 |
| Molecular Weight | 90581.0 |
| Theoretical pI | 4.89 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-4 MAYLLQGRLPINQDLLLMQKGTMMRKVRSKSWKKLRFFRLQDDGMTVWHARQAGGRAKPS FSISDVDTVREDHESELLRNLAEEFPLEQGFTIVFHGRRSNLDLVANSVQEAQTWMQGLQ LLVGFVTNMDQQERLDQWLSDWFQRGDKNQDGRMSFGEVQRLLHLMNVEMDQEYAFQLFQ TADTSQSGTLEGEEFVEFYKSLTQRPEVQELFEKFSSDGQKLTLLEFVDFLQEEQKEGER ASDLALELIDRYEPSESGKLRHVLSMDGFLGYLCSKDGDIFNPTCHPLYQDMTQPLNHYY INSSHNTYLVGDQLCGQSSVEGYIRALKRGCRCVEVDIWDGPSGEPIVYHGHTLTSRIPF KDVVAAIGQYAFQTSDYPVILSLENHCSWEQQEIIVRHLTEILGDQLLTTALDGQPPTQL PSPEDLRGKILVKGKKLMLEEEEEEPEAELEAEQEARLDLEAQLESEPQDLSPRSEDKKK VVMCPLLCRPLCCQIMAQAPISKPGLLLFPKQKPKAILCPALSALVVYLKAVTFYSFTHS REHYHFYETSSFSETKAKSLIKEAGDEFVQHNAWQLSRVYPSGLRTDSSNYNPQEFWNAG CQMVAMNMQTAGLEMDLCDGLFRQNAGCGYVLKPDFLRDAQSSFHPERPISPFKAQTLII QVISGQQLPKVDNTKEQSIVDPLVRVEIFGVRPDTTRQETSYVENNGFNPYWGQTLCFRI LVPELALLRFVVKDYDWKSRNDFIGQYTLPWSCMQQGYRHIHLLSKDGLSLHPASIFVHI CTQEVSEEAES |
| External Links | |
| GenBank ID Protein | AAI12450.1 |
| UniProtKB/Swiss-Prot ID | P21671 |
| UniProtKB/Swiss-Prot Entry Name | PLCD4_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | BC112449 |
| GeneCard ID | PLCD4 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |