Showing Protein 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 (BMDBP00074)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00074 |
| Secondary Accession Numbers | None |
| Name | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 |
| Synonyms | Not Available |
| Gene Name | PLCZ1 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in calcium ion binding |
| Specific Function | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function. |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 5 |
| Locus | Not Available |
| SNPs | PLCZ1 |
| Gene Sequence | Not Available |
| Protein Properties | |
| Number of Residues | 634 |
| Molecular Weight | 73732.0 |
| Theoretical pI | 7.01 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1 MENKWFLLMVRDDFKGGKITLEKALKLLEKLDIQCNTIHVKYIFKDNDRLKQGRITIEEF RTIYRIITYREEIIEIFNTYSENRKILLEKNLVEFLMREQYTLDFNKSIASEIIQKYEPI EEVKQAHQMSFEGFRRYMDSSECLLFDNKCDHVYQDMTHPLTDYFISSSHNTYLISDQLW GPSDLWGYISALVKGCRCLEIDCWDGSQNEPVVYHGYTFTSKLLFKTVIQAINKYAFLAS EYPVVLSLENHCSPSQQEVMADSLLATFGDALLSYTLDNFSDRLPSPEALKFKILVRNKK IGTLHETLERKGSDMHGKVEEFEEEEEIEQEEDGSGAKEPEPVGDFQDDLAKEEQLKRVV GIPLFRKKKIKISMALSDLVIYTKVEKFKSFHHSHLYQQFNESNSIGESQARKLTKLAAR EFILHTRRFITRVYPKALRADSSNFNPQEFWNVGCQMVALNFQTPGVPMDLQNGKFLDNG CSGYVLKPRFLRDKKTKFNPHKVQIDSNPLTLTIRLISGIQLPPSYQNKADTLVIVEIFG VPNDQMKQQSRVIKKNAFNPRWNETFTFVIQVPELALIRFVAENQGLIAGNEFLGQYTLP VLCMNRGYRRVPLFSKMGESLEPASLFIYVWYIR |
| External Links | |
| GenBank ID Protein | AAV54518.1 |
| UniProtKB/Swiss-Prot ID | Q1RML2 |
| UniProtKB/Swiss-Prot Entry Name | PLCZ1_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | AY646356 |
| GeneCard ID | PLCZ1 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |