Showing Protein 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (BMDBP00076)
| Identification | |||
|---|---|---|---|
| BMDB Protein ID | BMDBP00076 | ||
| Secondary Accession Numbers | None | ||
| Name | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | ||
| Synonyms | Not Available | ||
| Gene Name | PLCG1 | ||
| Protein Type | Enzyme | ||
| Biological Properties | |||
| General Function | Involved in calcium ion binding | ||
| Specific Function | Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration (By similarity). | ||
| Pathways |
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| Reactions |
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| GO Classification | Not Available | ||
| Cellular Location | Not Available | ||
| Gene Properties | |||
| Chromosome Location | 13 | ||
| Locus | Not Available | ||
| SNPs | PLCG1 | ||
| Gene Sequence |
>3876 bp ATGGCGGGCGCCGCGTCCCCCTGCGCCAACGGCTGCGGGCCCAGTGCGCCCTCGGACGCC GAGGTGGTGCACCTCTGCCGCAGCCTCGAGGTGGGCACCGTCATGACTTTGTTCTACTCC AAGAAGTCGCAGCGGCCCGAGCGGAAGACCTTCCAGGTCAAGCTGGAGACGCGGCAGATC ACGTGGAGCCGAGGCGCCGACAAGATAGAGGGGGCCATTGACATTCGTGAAATCAAGGAG ATCCGCCCAGGGAAGACCTCACGGGACTTCGATCGCTACCAAGAGGATCCTGCTTTTCGA CCGGACCAGTCCCACTGCTTCGTCATCCTGTATGGAATGGAATTCCGCCTGAAGACCCTG AGCCTCCAAGCCACGTCTGAGGACGAAGTGAACATGTGGATCAGGGGCCTGACTTGGCTG ATGGAGGACACGTTGCAGGCAGCCACACCCCTGCAGATTGAGAGGTGGCTGCGGAAGCAG TTCTACTCAGTGGACCGGAACCGTGAGGACCGGATATCGGCCAAGGACCTGAAGAACATG CTGTCCCAGGTCAACTACCGGGTCCCCAACATGCGCTTCCTCCGGGAGCGGCTGACGGAC CTGGAGCAGCGCACCAGTGACATCACCTACGGGCAGTTTGCACAGCTGTACCGCAGCCTC ATGTACAGCGCCCAGAAGACGATGGACCTTCCTTTCCTGGAAGCCAGCGCCCTGAGGGCG GGGGAGCGGCCGGAGCTGTGCCGGGTGTCCCTTCCTGAGTTCCAGCAGTTCCTCCTCGAG TACCAAGGGGAGCTGTGGGCGGTGGACCGGCTCCAGGTGCAGGAGTTCATGCTCAGCTTC CTCCGAGACCCCTTGCGAGAGATTGAGGAGCCTTACTTCTTCCTGGACGAGTTCGTCACC TTCCTGTTCTCCAAGGAGAACAGCATATGGAACTCGCAGCTAGACGAGGTGTGCCCCGAC ACCATGAACAACCCCCTGTCCCACTACTGGATCTCCTCCTCGCACAACACGTACCTGACC GGGGACCAGTTCTCCAGCGAGTCCTCCCTGGAAGCCTACGCTCGCTGCCTGCGGATGGGC TGCCGTTGCATTGAGTTGGACTGCTGGGACGGCCCGGATGGGATGCCGGTCATTTACCAT GGACACACTCTGACCACCAAGATCAAGTTCTCAGACGTCCTGCACACCATCAAGGAGCAC GCCTTTGTGGCCTCAGAGTACCCGGTCATCCTGTCCATCGAGGACCACTGCAGCATTGCC CAGCAGAGGAACATGGCCCAGTATTTCAAAAAGGTGCTTGGGGACACACTCCTCACCAAG CCCGTGGATATTGCAGCCGACGGGCTCCCCTCCCCCAACCAGCTCAAGAGGAAGATCCTT ATCAAGCACAAGAAGTTGGCTGAGGGCAGTGCCTACGAGGAGGTGCCAACATCGGTGATG TACTCTGAGAACGACATCAGCAACTCCATCAAGAATGGCATCCTCTACCTGGAAGACCCT GTGAACCATGAGTGGTACCCCCACTACTTCGTCCTGACCAGCAGCAAGATCTACTACTCG GAGGAGACCAGCAGCGACCAGGGCAACGAGGATGAGGAGGAGCCCAAGGAGGCCAGTGGC AGCACAGAGCTGCACTCCAACGAGAAGTGGTTCCACGGGAAGCTTGGGGCGGGCCGGGAT GGGCGGCACATCGCCGAGCGCCTGCTCACGGAGTACTGCATTGAGACCGGGGCCCCCGAC GGCTCCTTCCTTGTGCGCGAGAGCGAGACCTTTGTGGGCGACTACACTCTGTCCTTCTGG CGGAATGGCAAAGTGCAGCACTGCCGGATCCACTCCCGGCAGGACGCAGGCACCCCCAAG TTCTTCCTGACGGACAACCTCGTCTTCGACTCCCTCTATGACCTCATCACGCACTACCAG CAGGTGCCCCTGCGCTGCAACGAATTTGAGATGCGCCTCTCAGAGCCGGTCCCGCAGACC AACGCGCACGAGAGCAAAGAGTGGTACCACGCCAGCCTGACCAGAGCGCAGGCCGAGCAC ATGCTGATGCGTGTACCCAGGGACGGGGCCTTCCTGGTGCGGAAACGGAACGAGCCCAAC TCCTACGCCATCTCCTTCCGGGCTGAGGGCAAGATCAAGCACTGCCGCGTCCAGCAGGAG GGCCAGACCGTGATGCTGGGCAACTCAGAGTTTGACAGCCTTGTCGACCTCATCAGCTAC TACGAGAAGCACCCACTGTACCGCAAGATGAAGCTGCGCTACCCCATCAACGAGGAGGCT CTGGAGAAGATCGGCACAGCTGAGCCTGACTACGGCGCGCTGTACGAGGGCCGCAACCCT GGCTTCTATGTGGAGGCGAACCCCATGCCCACGTTCAAGTGCGCCGTCAAAGCTCTCTTC GACTACAAAGCGCAGCGGGAGGACGAGCTGACATTCACCAAGAGTGCCATCATCCAGAAC GTGGAGAAGCAGGAGGGAGGCTGGTGGCGGGGTGACTACGGCGGGAAGAAGCAGCTGTGG TTCCCTTCAAACTATGTGGAGGAAATGGTCAGCCCGGCGGCCCTGGAGCCCGAGAGGGAG CACTTGGACGAGAACAGCCCACTCGGGGACTTGCTCCGGGGGGTCCTGGATGTGCCAGCT TGTCAGATAGCCGTCCGTCCCGAGGGCAAGAACAACCGGCTGTTCGTCTTCTCCATCAGC ATGGCCTCGGTGGCACACTGGTCCCTGGATGTGGCTGCCGACTCGCAGGAAGAGCTGCAG GACTGGGTGAAGAAGATCCGGGAGGTGGCGCAGACAGCGGATGCCAGGCTCACCGAGGGC AAGATGATGGAGCGGAGGAAGAAGATCGCCCTAGAGCTCTCAGAGCTCGTCGTCTACTGC CGGCCTGTCCCTTTCGACGAAGAGAAGATTGGCACCGAACGGGCCTGCTACCGCGACATG TCGTCCTTCCCGGAGACCAAGGCCGAGAAGTACGTGAACAAGGCCAAAGGCAAGAAGTTC CTCCAGTACAACCGCCTGCAGCTCTCCCGCATCTACCCTAAGGGCCAGCGGCTGGACTCC TCCAATTACGACCCCCTGCCCATGTGGATCTGCGGCAGCCAGCTTGTGGCCCTCAACTTC CAGACCCCAGACAAACCCATGCAGATGAACCAGGCCCTGTTCCTGGCCGGCGGGCACTGT GGCTATGTGCTGCAGCCCAGCGTCATGCGCGATGAGGCCTTCGATCCCTTTGACAAGAGC AGCCTCCGCGGGCTGGAGCCGTGCGCCATCTGCATCGAGGTGCTGGGGGCCCGGCACCTG CCGAAGAACGGCCGAGGCATCGTGTGTCCTTTTGTGGAGATCGAGGTGGCCGGAGCCGAG TATGACAGCATCAAGCAGAAGACAGAGTTTGTGGTGGACAATGGACTGAACCCCGTGTGG CCAGCCAAGCCCTTCCACTTCCAGATTAGTAACCCCGAGTTCGCCTTCCTGCGCTTCGTG GTCTATGAGGAGGACATGTTTAGTGACCAGAACTTCCTAGCTCAGGCTACCTTCCCAGTG AAGGGTCTGAAGACAGGCTACAGAGCGGTGCCTCTGAAGAACAACTACAGTGAGGGCCTG GAGCTGGCCTCCCTGCTCGTCAAGATTGACGTGTTCCCTGCCAAGCAGGAGAACGGCGAC CTCAGCCCCTTCGGGGGTGCGTCCCTGCGGGAGCGGAGCTGTGACGCCTCGGGCCCGCTG TTCCACGGCCGGGCCCGGGAGGGCTCCTTTGAAGCTCGCTACCAGCAGCCCTTTGAGGAC TTCCGCATCTCCCAGGAGCATCTCGCAGACCATTTTGACGGTCGGGATCGCAGGACCCCA CGCAGGACTCGGGTCAACGGAGACAACCGCCTGTAG |
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| Protein Properties | |||
| Number of Residues | 1291 | ||
| Molecular Weight | 148313.0 | ||
| Theoretical pI | 5.85 | ||
| Pfam Domain Function | Not Available | ||
| Signals |
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| Transmembrane Regions | Not Available | ||
| Protein Sequence |
>1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 MAGAASPCANGCGPSAPSDAEVVHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI TWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTL SLQATSEDEVNMWIRGLTWLMEDTLQAATPLQIERWLRKQFYSVDRNREDRISAKDLKNM LSQVNYRVPNMRFLRERLTDLEQRTSDITYGQFAQLYRSLMYSAQKTMDLPFLEASALRA GERPELCRVSLPEFQQFLLEYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVT FLFSKENSIWNSQLDEVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG CRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIA QQRNMAQYFKKVLGDTLLTKPVDIAADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSVM YSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEASG STELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW RNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQE GQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNP GFYVEANPMPTFKCAVKALFDYKAQREDELTFTKSAIIQNVEKQEGGWWRGDYGGKKQLW FPSNYVEEMVSPAALEPEREHLDENSPLGDLLRGVLDVPACQIAVRPEGKNNRLFVFSIS MASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKMMERRKKIALELSELVVYC RPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDS SNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFLAGGHCGYVLQPSVMRDEAFDPFDKS SLRGLEPCAICIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSIKQKTEFVVDNGLNPVW PAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEGL ELASLLVKIDVFPAKQENGDLSPFGGASLRERSCDASGPLFHGRAREGSFEARYQQPFED FRISQEHLADHFDGRDRRTPRRTRVNGDNRL |
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| External Links | |||
| GenBank ID Protein | CAA68406.1 | ||
| UniProtKB/Swiss-Prot ID | P08487 | ||
| UniProtKB/Swiss-Prot Entry Name | PLCG1_BOVIN | ||
| PDB IDs | |||
| GenBank Gene ID | Y00301 | ||
| GeneCard ID | PLCG1 | ||
| GenAtlas ID | Not Available | ||
| HGNC ID | Not Available | ||
| References | |||
| General References | Not Available | ||