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| Identification |
|---|
| BMDB Protein ID
| BMDBP00083 |
| Secondary Accession Numbers
| None |
| Name
| Serine hydroxymethyltransferase, mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| SHMT2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Amino acid transport and metabolism |
| Specific Function
| Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis. Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA. Also required for mitochondrial translation by producing 5,10-methylenetetrahydrofolate; 5,10-methylenetetrahydrofolate providing methyl donors to produce the taurinomethyluridine base at the wobble position of some mitochondrial tRNAs. Associates with mitochondrial DNA. In addition to its role in mitochondria, also plays a role in the deubiquitination of target proteins as component of the BRISC complex: required for IFNAR1 deubiquitination by the BRISC complex. |
| Pathways
|
- Glycine and Serine Metabolism
- One-carbon metabolism
- Tetrahydrofolate interconversion
|
| Reactions
|
| 5,10-Methylene-THF + Glycine + Water → Tetrahydrofolic acid + L-Serine |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 5 |
| Locus
| Not Available |
| SNPs
| SHMT2 |
| Gene Sequence
|
>1515 bp
ATGTTGTCCTTCTCTTTTATTTGGGCGACTCGGCCTCTGCGGAGATGTGGTCAGCTGGTT
GGGATGGCCGTACGGTGCCAGCACAGTGAGGCGGCCCAGACTCAGACTGGAGAAGCAAGC
AAGGGCTGGTCAGGCCAGGAGAGTCTATCAGACAGTGACCCTGAGATGTGGGAGCTGCTG
CGGAGAGAGAAGGACAGGCAGTGTCGCGGCCTGGAGCTCATTGCTTCAGAGAACTTCTGC
AGCCGAGCTGCGCTGGAGGCCCTGGGGTCCTGTCTGAACAACAAGTACTCGGAGGGTTAT
CCTGGCAAGAGATACTACGGAGGAGCAGAGGTAGTGGATGAGATAGAGCTGCTGTGTCAG
CGCCGGGCCTTGGAGGCCTTTGACCTGGATCCTGCTCAGTGGGGAGTCAATGTCCAACCC
TACTCCGGATCCCCAGCCAATCTGGCTGCCTACACAGCCCTTCTGCAGCCTCACGACCGA
ATCATGGGGCTGGACTTGCCCGATGGGGGCCATCTCACCCACGGCTACATGTCTGATGTC
AAGCGGATCTCAGCTACATCTATCTTCTTCGAGTCTATGCCTTATAAGCTGAACCCCCAA
ACCGGCCTCATTGACTATGACCAGCTGGCACTCACTGCTCGGCTCTTCAAACCACGACTC
ATCATAGCTGGTACCAGTGCCTATGCTCGTCTCATTGACTACGCCCGCATGAGAGAAGTG
TGTGACGAGGTCAAGGCACACCTCTTGGCAGACATGGCCCACATCAGTGGCCTGGTGGCT
GCCAAGGTGATCCCCTCACCCTTCAAGCACGCGGATATTGTCACCACGACCACTCACAAG
ACCCTTCGAGGGGCCAGGTCAGGACTCATCTTCTACCGGAAGGGGGTGCAGGCTGTGGAC
CCCAAAACTGGCCGAGAGATCCCTTACACATTTGAGGACCGAATCAACTTTGCTGTGTTC
CCATCCCTGCAGGGGGGCCCCCACAACCATGCCATTGCTGCAGTGGCTGTGGCCCTAAAG
CAGGCCTGCACCCCCATGTTCCGGGAGTACTCCCTGCAGATTCTAAAGAACGCTCAGGCC
ATGGCTAATGCCCTGCTGGAGCGAGGCTACTCCCTGGTGTCTGGTGGCACTGACAACCAC
CTAGTGCTGGTAGACCTTCGGCCAAAGGGCCTGGACGGAGCTCGAGCAGAACGGGTGTTG
GAACTTGTATCCATCACGGCCAACAAGAACACCTGTCCTGGAGATCGAAGTGCCATCACC
CCTGGGGGCCTGAGGCTGGGGGCCCCAGCCCTGACTTCTCGAGGGTTCCTTGAAGATGAC
TTCCGGAAAGTTGTAGGCTTTATAGATGAAGGTGTCAACATTGGCTTGGAAGTGAAGAGC
AAGACCACCAAACTCCAGGATTTCAAATCTTTCCTGCTCAAAGACCCAGAAACAAGTCAT
CAGCTGGCCGACCTTAGGCAACGGGTGGAGCAGTTCGCCAGGGCCTTCCCCATGCCTGGT
TTTGATGATCACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 504 |
| Molecular Weight
| 55605.0 |
| Theoretical pI
| 7.78 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Serine hydroxymethyltransferase, mitochondrial
MLSFSFIWATRPLRRCGQLVGMAVRCQHSEAAQTQTGEASKGWSGQESLSDSDPEMWELL
RREKDRQCRGLELIASENFCSRAALEALGSCLNNKYSEGYPGKRYYGGAEVVDEIELLCQ
RRALEAFDLDPAQWGVNVQPYSGSPANLAAYTALLQPHDRIMGLDLPDGGHLTHGYMSDV
KRISATSIFFESMPYKLNPQTGLIDYDQLALTARLFKPRLIIAGTSAYARLIDYARMREV
CDEVKAHLLADMAHISGLVAAKVIPSPFKHADIVTTTTHKTLRGARSGLIFYRKGVQAVD
PKTGREIPYTFEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPMFREYSLQILKNAQA
MANALLERGYSLVSGGTDNHLVLVDLRPKGLDGARAERVLELVSITANKNTCPGDRSAIT
PGGLRLGAPALTSRGFLEDDFRKVVGFIDEGVNIGLEVKSKTTKLQDFKSFLLKDPETSH
QLADLRQRVEQFARAFPMPGFDDH
|
| External Links |
|---|
| GenBank ID Protein
| AAI03243.1 |
| UniProtKB/Swiss-Prot ID
| Q3SZ20 |
| UniProtKB/Swiss-Prot Entry Name
| GLYM_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC103242 |
| GeneCard ID
| SHMT2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
