Showing Protein Serine palmitoyltransferase 1 (BMDBP00085)
| Identification | |||
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| BMDB Protein ID | BMDBP00085 | ||
| Secondary Accession Numbers | None | ||
| Name | Serine palmitoyltransferase 1 | ||
| Synonyms | Not Available | ||
| Gene Name | SPTLC1 | ||
| Protein Type | Enzyme | ||
| Biological Properties | |||
| General Function | Coenzyme transport and metabolism | ||
| Specific Function | Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference (By similarity). Required for adipocyte cell viability and metabolic homeostasis (By similarity). | ||
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| GO Classification | Not Available | ||
| Cellular Location | Not Available | ||
| Gene Properties | |||
| Chromosome Location | 8 | ||
| Locus | Not Available | ||
| SNPs | SPTLC1 | ||
| Gene Sequence |
>1422 bp ATGGCGACCGTCGCGGAGCAGTGGGTCCTGGTGGAGATGGTCCAGGCGCTCTACGAGGCT CCTGCTTATCATCTTATTTTAGAAGGAATTTTAATACTCTGGATAATCAGACTTCTTTTC TCTAAAACTTACAAATTACAAGAACGATCTGATCTTACACTCAAGGAAAAGGAAGAATTG ATTGAAGAGTGGCAACCAGAGCCTCTTGTTCCTCCTGTCTCAAAAGACCATCCTGCTCTC AACTACAACATTGTTTCAGGCCCTCCAAGCCATAACATCGTGGTGAATGGAAAAGAATGT ATAAACTTTGCTTCATTCAATTTTCTTGGATTGTTGGATAACCCTAGGCTCAAGGCAGCA GCTTTGGCATCTCTAAAGAAGTATGGTGTGGGAACTTGTGGACCTAGAGGATTTTATGGC ACATTTGATGTGCACTTGGATTTAGAAGACCGCCTGGCAAAATTTATGAAGACAGAAGAA GCCATAATATACTCATATGGATTTGCCACCATAGCCAGTGCTATTCCTGCTTACTCTAAG AGAGGGGACATTGTGTTTGTAGATAAAGCTGCCTGCTTTGCTATTCAGAAGGGATTACAG GCATCACGTAGTGACATTAAGGTGTTTAACCATAATGATATGGACGACCTGGAGCGACTA CTAAAAGAACAAGAGATTGAAGATCAAAAGAATCCTCGCAAGGCTCGTGTAACTCGACGT TTCATTATAGTTGAAGGATTGTATATGAATACTGGAACTGTTTGCCCTCTTCCAGAATTG GTTAAGTTAAAATATAAATATAAAGCAAGAATCTTTCTGGAGGAAAGCCTTTCATTTGGA GTCCTGGGAGAGCATGGCCGAGGAGTCACGGAACATTTTGGAATCAGTATTGATGATATT GATCTTATCAGTGCCAACATGGAGAACTCACTGGCATCTATTGGGGGTTTCTGCTGTGGC AGGTCTTTCGTAATTGACCATCAGCGACTTTCTGGCCAGGGATACTGCTTTTCAGCTTCG TTACCTCCCCTGTTAGCTGCTGCTGCGATTGAGGCTCTCAACATCATGGAAGAGAATCCA GGTATTTTTGCAGTGTTGAAGGAAAAATGCAAACGAATTCATAAAGCTTTACAAGGCATT CCTGGACTAAAAGTAGTGGGGGAGTCTATTTCTCCAGCATTGCACCTCCAACTGGAAGAG ACCACTGGGTGTCGAGAAAGAGATGTTAAACTGCTTCAGGAAATAGTAACTCAATGCATG GACAGAGGCATCGCATTGACTCAGGCACGCTACTTGGAGAAAGAAGAAAAGTACCTCCCC CCTCCGAGCATTAGGGTTGTGGTCACAGTGGAACAAACAGAAGAGGACCTGGAGAAAGCT GCGTCCACGATCAGCGAGGTGGCCCAGACCGTGCTGCTTTAG |
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| Protein Properties | |||
| Number of Residues | 473 | ||
| Molecular Weight | 52788.0 | ||
| Theoretical pI | 5.7 | ||
| Pfam Domain Function | Not Available | ||
| Signals |
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| Protein Sequence |
>Serine palmitoyltransferase 1 MATVAEQWVLVEMVQALYEAPAYHLILEGILILWIIRLLFSKTYKLQERSDLTLKEKEEL IEEWQPEPLVPPVSKDHPALNYNIVSGPPSHNIVVNGKECINFASFNFLGLLDNPRLKAA ALASLKKYGVGTCGPRGFYGTFDVHLDLEDRLAKFMKTEEAIIYSYGFATIASAIPAYSK RGDIVFVDKAACFAIQKGLQASRSDIKVFNHNDMDDLERLLKEQEIEDQKNPRKARVTRR FIIVEGLYMNTGTVCPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHFGISIDDI DLISANMENSLASIGGFCCGRSFVIDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEENP GIFAVLKEKCKRIHKALQGIPGLKVVGESISPALHLQLEETTGCRERDVKLLQEIVTQCM DRGIALTQARYLEKEEKYLPPPSIRVVVTVEQTEEDLEKAASTISEVAQTVLL |
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| External Links | |||
| GenBank ID Protein | AAI05251.1 | ||
| UniProtKB/Swiss-Prot ID | Q3MHG1 | ||
| UniProtKB/Swiss-Prot Entry Name | SPTC1_BOVIN | ||
| PDB IDs | Not Available | ||
| GenBank Gene ID | BC105250 | ||
| GeneCard ID | SPTLC1 | ||
| GenAtlas ID | Not Available | ||
| HGNC ID | Not Available | ||
| References | |||
| General References | Not Available | ||