Showing Protein Serine--tRNA ligase, cytoplasmic (BMDBP00086)
| Identification | |||
|---|---|---|---|
| BMDB Protein ID | BMDBP00086 | ||
| Secondary Accession Numbers | None | ||
| Name | Serine--tRNA ligase, cytoplasmic | ||
| Synonyms | Not Available | ||
| Gene Name | SARS1 | ||
| Protein Type | Enzyme | ||
| Biological Properties | |||
| General Function | Translation, ribosomal structure and biogenesis | ||
| Specific Function | Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC. Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA. | ||
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| GO Classification | Not Available | ||
| Cellular Location | Not Available | ||
| Gene Properties | |||
| Chromosome Location | 3 | ||
| Locus | Not Available | ||
| SNPs | SARS1 | ||
| Gene Sequence |
>1545 bp ATGGTGCTGGATCTGGATTTGTTTCGGGTGGATAAAGGGGGGGACCCAGCACTCATCCGA GAGTCGCAGGAGAAGCGCTTCAAGGACCCGGGACTGGTGGACCAGCTGGTGAAGGCAGAC AGCGAGTGGCGACGATGCAGATTTCGGGCAGACAACTTGAACAAGCTGAAGAACCTATGC AGCAAGACAATTGGAGAGAAAATGAAGAAAAAAGAGCCAGTGGGAAATGATGAGTCCATT CCAGAAGATGTATTAAATCTCGATGACCTCACTGCAGACACTTTAACTAACCTAAAAGTC TCACAGATCAAAAAAGTCCGCCTCCTCGTCGACGAAGCCATCCTGAAGTGTGACGCCGAG CGGATAAAACTGGAAGCTGAGCGGTTTGAGAGCCTTCGGGAGATCGGGAACCTCCTGCAC CCGTCGGTGCCCATCAGCGATGACGAGGATGCCGACAACAAAGTAGAGAGGATTTGGGGT GATTGTACAGTCAGGAAGAAGTACTCTCACGTGGACCTGGTGGTGATGGTAGATGGCTTT GAAGGCGAAAAGGGGGCCGTGGTGGCTGGGAGTCGAGGGTACTTCCTGAAGGGGGTCCTG GTGTTCCTGGAACAAGCACTCATCCAGTTTGCCCTTCGGACCTTGGCAAGTCGGGGCTAC ACTCCCATTTATACCCCCTTCTTCATGAGGAAGGAGGTCATGCAGGAAGTGGCACAGCTC AGCCAGTTTGATGAAGAACTTTATAAGGTGATTGGCAAAGGCAGTGAAAAGTCTGATGAT AACTCCTATGAGGAGAAATATCTGATTGCTACCTCTGAACAACCCATTGCTGCTCTTCAC CGGGACGAGTGGCTTCGGCCAGAGGACTTGCCAATCAAGTATGCCGGCCTGTCCACCTGC TTTCGCCAGGAGGTGGGCTCCCATGGGCGTGACACCCGTGGCATCTTTAGAGTCCATCAG TTTGAGAAGATAGAGCAGTTTGTNTACTCCTCGCCACACGACAACAAGTCCTGGGAGATG TTTGAGGAGATGATTGCCACCGCGGAGGAGTTCTACCAGTCTCTGGGGATCCCTTACCAC ATCGTGAATATCGTCTCAGGTTCTTTGAATCATGCTGCCAGTAAGAAGCTTGACCTGGAG GCCTGGTTTCCAGGCTCGGGGGCCTTCCGTGAGTTAGTCTCCTGTTCTAACTGCACAGAC TATCAGGCTCGCCGGCTCCGAATCCGATATGGGCAGACCAAGAAGATGATGGACAAGGTG GAGTTTGTCCACATGCTCAATGCCACCATGTGTGCCACAACCCGCACCATCTGTGCCATC CTGGAGAACTACCAGACAGAGAAGGGCATCCTCGTGCCTGAGAAATTGAAGGAATTCATG CCGCCAGGTCTCCAAGAACTGATCCCCTTTGTGAAGGCTGCGCCCATTGACCAGGAGCCC TCCAAGAAGCAGAAGAAGCAGCATGAGGGCAGCAAGAAGAAAGGGGCAGCGAGAGATGTT GCCCTGGAGAGCCAGCTGCAGAACATGGAGGTCACCGATGCCTGA |
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| Protein Properties | |||
| Number of Residues | 514 | ||
| Molecular Weight | 58605.0 | ||
| Theoretical pI | 6.07 | ||
| Pfam Domain Function | Not Available | ||
| Signals |
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| Transmembrane Regions | Not Available | ||
| Protein Sequence |
>Seryl-tRNA synthetase, cytoplasmic MVLDLDLFRVDKGGDPALIRESQEKRFKDPGLVDQLVKADSEWRRCRFRADNLNKLKNLC SKTIGEKMKKKEPVGNDESIPEDVLNLDDLTADTLTNLKVSQIKKVRLLVDEAILKCDAE RIKLEAERFESLREIGNLLHPSVPISDDEDADNKVERIWGDCTVRKKYSHVDLVVMVDGF EGEKGAVVAGSRGYFLKGVLVFLEQALIQFALRTLASRGYTPIYTPFFMRKEVMQEVAQL SQFDEELYKVIGKGSEKSDDNSYEEKYLIATSEQPIAALHRDEWLRPEDLPIKYAGLSTC FRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMIATAEEFYQSLGIPYH IVNIVSGSLNHAASKKLDLEAWFPGSGAFRELVSCSNCTDYQARRLRIRYGQTKKMMDKV EFVHMLNATMCATTRTICAILENYQTEKGILVPEKLKEFMPPGLQELIPFVKAAPIDQEP SKKQKKQHEGSKKKGAARDVALESQLQNMEVTDA |
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| External Links | |||
| GenBank ID Protein | AAG03084.1 | ||
| UniProtKB/Swiss-Prot ID | Q9GMB8 | ||
| UniProtKB/Swiss-Prot Entry Name | SYSC_BOVIN | ||
| PDB IDs | Not Available | ||
| GenBank Gene ID | AF297553 | ||
| GeneCard ID | SARS1 | ||
| GenAtlas ID | Not Available | ||
| HGNC ID | Not Available | ||
| References | |||
| General References | Not Available | ||