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| Identification |
|---|
| BMDB Protein ID
| BMDBP00087 |
| Secondary Accession Numbers
| |
| Name
| Serine hydroxymethyltransferase, cytosolic |
| Synonyms
|
Not Available
|
| Gene Name
| SHMT1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Amino acid transport and metabolism |
| Specific Function
| Interconversion of serine and glycine. |
| Pathways
|
- One-carbon metabolism
- Tetrahydrofolate interconversion
|
| Reactions
|
| 3-Hydroxy-N6,N6,N6-trimethyl-L-lysine → Glycine + 4-Trimethylammoniobutanal |
details
|
| L-Serine + Tetrahydrofolic acid → Glycine + 5,10-Methylene-THF + Water |
details
|
| Tetrahydrofolic acid + L-Serine → 5,10-Methylene-THF + Glycine + Water |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 19 |
| Locus
| Not Available |
| SNPs
| SHMT1 |
| Gene Sequence
|
>1455 bp
ATGGCAGCTCCAGTCAACAAGGCACCCAGAGATGCCAATTTGTGGTCCTTGCACGAGAAG
ATGCTGGCACAGCCCCTGAAGGACAACGATGTCGAGGTTTACAACATCATTAAGAAGGAG
AGTAACCGGCAGAGGGTTGGACTGGAGCTGATCGCCTCCGAGAACTTTGCCAGCCGGGCT
GTTCTGGAGGCCCTAGGCTCTTGCCTGAACAACAAGTACTCTGAGGGGTACCCAGGCCAG
AGGTACTATGGTGGGACGGAGTTCATCGACGAGCTAGAGGTCCTCTGTCAGAAGCGAGCG
CTGCAGGTCTATGGCCTGGACTCCCAGTGCTGGGGGGTTAACGTCCAGCCTTACTCAGGC
TCCCCAGCAAACTTCGCAGTGTACACGGCCCTGGTGGAGCCCCATGGCCGCATCATGGGC
CTGGACCTGCCAGATGGGGGCCACCTGACCCATGGGTTCATGACTGACAAGAAGAAGATT
TCTGCCACGTCCATCTTTTTTGAATCTATGCCCTACAAGGTGAATCCCGATACCGGCTAC
ATCAACTACGACCAGCTGGAGGAGAACGCCCGCCTCTTCCACCCGAGGCTGATCATTGCT
GGGACTAGCTGCTACTCCCGGAACCTGGACTACGCTCGGCTGCGCAAGATCGCTGATGAC
AACGGGGCGTACCTCATGGCCGACATGGCACATGTCAGTGGGCTGGTGGCGGCCGGCGTG
GTGCCTTCGCCCTTCGAGCACTGCCACGTGGTGTCCACCACCACCCACAAGACCCTGCGG
GGCTGCCGCGCCGGCATGATCTTCTACAGGAAGGGAGTGCGCAGTGTGGACCCCAAGACA
GGCAGAGAGACTCGCTACAACCTGGAGTCGCTCATCAACTCTGCTGTGTTCCCAGGCCTG
CAAGGGGGACCCCACAACCACGCCATTGCTGGGGTCGCGGTTGCTCTGAAGCAGGCCATG
ACTCCAGAATTCAGAGCCTACCAGCGCCAGGTGGTGGCCAACTGCAGGGCTCTGGCCGAG
GCCTTGATGGGACTGGGCTACAGAGTGGTCACAGGGGGTTCTGACAACCACTTGATCCTC
GTGGACCTCCGCTCCAAAGGCACAGATGGCGGCAGGGCAGAGAAAGTGCTGGAAGCCTGC
TCCATTGCCTGCAATAAGAACACCTGCCCAGGTGATAAAAGCGCGCTACGGCCCAGTGGG
CTGCGCCTGGGGACCCCAGCATTGACCTCCCGAGGGCTCTTGGAAGAAGATTTCCAAAAG
GTCGCCCATTTCATTCACAGAGGCATAGAGCTGACCCTGCAGATCCAGGACGCCGTAGGG
GTGAAGGCCACCCTGAAGGAGTTCATGGAGAAGCTGGCAGGGGCCGAGGAGCACCATCGG
GCCGTGGCGGCCCTCAGGGCAGAGGTGGAGAGCTTCGCCACCCTATTCCCGCTGCCTGGC
CTGCCTGGCTTCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 484 |
| Molecular Weight
| 52978.0 |
| Theoretical pI
| 8.11 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Serine hydroxymethyltransferase, cytosolic
MAAPVNKAPRDANLWSLHEKMLAQPLKDNDVEVYNIIKKESNRQRVGLELIASENFASRA
VLEALGSCLNNKYSEGYPGQRYYGGTEFIDELEVLCQKRALQVYGLDSQCWGVNVQPYSG
SPANFAVYTALVEPHGRIMGLDLPDGGHLTHGFMTDKKKISATSIFFESMPYKVNPDTGY
INYDQLEENARLFHPRLIIAGTSCYSRNLDYARLRKIADDNGAYLMADMAHVSGLVAAGV
VPSPFEHCHVVSTTTHKTLRGCRAGMIFYRKGVRSVDPKTGRETRYNLESLINSAVFPGL
QGGPHNHAIAGVAVALKQAMTPEFRAYQRQVVANCRALAEALMGLGYRVVTGGSDNHLIL
VDLRSKGTDGGRAEKVLEACSIACNKNTCPGDKSALRPSGLRLGTPALTSRGLLEEDFQK
VAHFIHRGIELTLQIQDAVGVKATLKEFMEKLAGAEEHHRAVAALRAEVESFATLFPLPG
LPGF
|
| External Links |
|---|
| GenBank ID Protein
| AAX08888.1 |
| UniProtKB/Swiss-Prot ID
| Q5E9P9 |
| UniProtKB/Swiss-Prot Entry Name
| GLYC_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BT020871 |
| GeneCard ID
| SHMT1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
