Bovine Metabolome Database: Showing Protein Inositol-tetrakisphosphate 1-kinase (BMDBP00089)

You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on Bovine Metabolome Database.

Identification Biological properties Gene properties Protein properties External links References XML Show 8 metabolites

Identification

BMDB Protein ID

BMDBP00089

Secondary Accession Numbers

None

Name

Inositol-tetrakisphosphate 1-kinase

Synonyms

Not Available

Gene Name

ITPK1

Protein Type

Enzyme

Biological Properties

General Function

Involved in ATP binding

Specific Function

Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain (By similarity). Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Plays an important role in MLKL-mediated necroptosis. Produces highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which bind to MLKL mediating the release of an N-terminal auto-inhibitory region leading to its activation. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis (By similarity).

Pathways

Inositol Metabolism
Inositol Phosphate Metabolism

Reactions

Inositol 1,3,4,5,6-pentakisphosphate + ADP → D-Myo-inositol 3,4,5,6-tetrakisphosphate + Adenosine triphosphate	details
Adenosine triphosphate + Inositol 1,3,4-trisphosphate → ADP + 1D-Myo-inositol 1,3,4,6-tetrakisphosphate	details
Inositol 1,3,4-trisphosphate + Adenosine triphosphate → Inositol 1,3,4,5-tetraphosphate + ADP	details

GO Classification

Not Available

Cellular Location

Not Available

Gene Properties

Chromosome Location

Locus

Not Available

SNPs

ITPK1

Gene Sequence

Not Available

Protein Properties

Number of Residues

419

Molecular Weight

45842.0

Theoretical pI

6.09

Pfam Domain Function

Not Available

Signals

None

Transmembrane Regions

Not Available

Protein Sequence

>Inositol-tetrakisphosphate 1-kinase
MQTFLKGKRVGYWLSEKKIKKLNFQAFAELCRKRGIEVVQLNLSRPIEEQGPLDVIIHKL
TDVILEADQNDSQALELVHRFQEYIDAHPETIVLDPLPAIRTLLDRSKSYELIRKIEAYM
KDDRICSPPFMELTSLCGDDTMRLLEENGLAFPFICKTRVAHGTNSHEMAIVFNQEGLSA
IQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESIFFNSHNVSKPES
SSVLTALDKIEGVFERPSDEVIRELSRALRQALGVSLFGIDIIINNQTGQHAVIDINAFP
GYEGVSEFFTDLLNHIASVLQGQSSGVAGAGDVAPLKHSRLLAEQAGGLAAERTCSASPG
CCSSMMGQEPPWTPEADMGGVGAGSTAKLPHQRLGCTAGVSPSFQQHCVASLATKASSQ

External Links

GenBank ID Protein

Not Available

UniProtKB/Swiss-Prot ID

P0C0T1

UniProtKB/Swiss-Prot Entry Name

ITPK1_BOVIN

PDB IDs

Not Available

GenBank Gene ID

DT820636

GeneCard ID