Showing Protein Prostaglandin-H2 D-isomerase (BMDBP00102)
| Identification | |||
|---|---|---|---|
| BMDB Protein ID | BMDBP00102 | ||
| Secondary Accession Numbers |
|
||
| Name | Prostaglandin-H2 D-isomerase | ||
| Synonyms | Not Available | ||
| Gene Name | PTGDS | ||
| Protein Type | Enzyme | ||
| Biological Properties | |||
| General Function | Involved in prostaglandin-D synthase activity | ||
| Specific Function | Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system (By similarity). | ||
| Pathways | Not Available | ||
| Reactions |
|
||
| GO Classification | Not Available | ||
| Cellular Location | Not Available | ||
| Gene Properties | |||
| Chromosome Location | 11 | ||
| Locus | Not Available | ||
| SNPs | PTGDS | ||
| Gene Sequence |
>576 bp ATGGCCACTCCGAATAGGCTGTGGATGGCGCTGCTCCTGCTGGGGGTCCTGGGGGTCCTG CAGACCCCAGCCCCCGCCCAGGCCGCCCTGCAGCCCAACTTCGAAGAGGACAAGTTTCTG GGGCGCTGGTTCACCTCCGGCCTTGCCTCCAACTCGAGCTGGTTCCTGGAGAAGAAGAAG GTGCTGTCCATGTGCAAGTCTGTGGTGGCCCCCGCGGCGGACGGCGGCCTCAACCTCACC TCTACCTTCCTCAGGAAAGACCAGTGTGAGACGCGGACCTTACTGCTGCGCCCCGCCGGC CCCCCAGGCTGCTACAGCTACACCAGCCCTCACTGGAGCAGCACCCACGAGGTGTCAGTG GCAGAGACAGACTACGAGACCTACGCCCTGCTCTACACAGAGGGTGTCCGAGGCCCGGGG CAGGACTTCCGCATGGCCACGCTCTACAGCCGCTCCCAGAACCCCCGAGCCGAGGTCAAG GAACACTTCACCACCTTTGCCAAGAGCCTGGGCTTCACAGAGGAAGGCATTGTGTTCCTG CCGAAGACTGACAAGTGCATGGAGGAGCACCCATAG |
||
| Protein Properties | |||
| Number of Residues | 191 | ||
| Molecular Weight | 21229.0 | ||
| Theoretical pI | 6.92 | ||
| Pfam Domain Function | Not Available | ||
| Signals |
|
||
| Transmembrane Regions | Not Available | ||
| Protein Sequence |
>Prostaglandin-H2 D-isomerase MATPNRLWMALLLLGVLGVLQTPAPAQAALQPNFEEDKFLGRWFTSGLASNSSWFLEKKK VLSMCKSVVAPAADGGLNLTSTFLRKDQCETRTLLLRPAGPPGCYSYTSPHWSSTHEVSV AETDYETYALLYTEGVRGPGQDFRMATLYSRSQNPRAEVKEHFTTFAKSLGFTEEGIVFL PKTDKCMEEHP |
||
| External Links | |||
| GenBank ID Protein | BAA20431.1 | ||
| UniProtKB/Swiss-Prot ID | O02853 | ||
| UniProtKB/Swiss-Prot Entry Name | PTGDS_BOVIN | ||
| PDB IDs | Not Available | ||
| GenBank Gene ID | AB004647 | ||
| GeneCard ID | PTGDS | ||
| GenAtlas ID | Not Available | ||
| HGNC ID | Not Available | ||
| References | |||
| General References | Not Available | ||