Showing Protein Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 (BMDBP00106)
| Identification | |||||
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| BMDB Protein ID | BMDBP00106 | ||||
| Secondary Accession Numbers | None | ||||
| Name | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 | ||||
| Synonyms | Not Available | ||||
| Gene Name | NMNAT2 | ||||
| Protein Type | Enzyme | ||||
| Biological Properties | |||||
| General Function | Coenzyme transport and metabolism | ||||
| Specific Function | Nicotinamide/nicotinate-nucleotide adenylyltransferase that acts as an axon maintenance factor (By similarity). Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannot use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity prefers NAD(+), NADH and NaAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+) (By similarity). Axon survival factor required for the maintenance of healthy axons: acts by delaying Wallerian axon degeneration, an evolutionarily conserved process that drives the loss of damaged axons (By similarity). | ||||
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| Reactions |
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| GO Classification | Not Available | ||||
| Cellular Location | Not Available | ||||
| Gene Properties | |||||
| Chromosome Location | 16 | ||||
| Locus | Not Available | ||||
| SNPs | NMNAT2 | ||||
| Gene Sequence |
>924 bp ATGACCGAGACCACCAAGACGCACGTTATCTTGCTCGCCTGCGGCAGCTTCAATCCCATC ACCAAAGGGCACATTCAGATGTTCGAAAGAGCCAGGGATTATCTGCACAAAACTGGAAGG TTTATTGTCATTGGCGGGATCGTGTCTCCTGTCCACGACTCCTATGGAAAACAGGGTCTT GTGTCAAGCCGGCACCGTCTCATCATGTGTCAGCTGGCCGTCCAGAATTCTGACTGGATC AGGGTGGACCCATGGGAGTGCTACCAGGACACCTGGCAGACGACCTGCAGCGTCCTCGAA CACCATCGGGACCTCATGAAGCGGGTGACTGGCTGCATCCTCTCCAACGTCAACACACCC TCCATGACACCTGTGATCGGACAGCCCCGAAATGAGACCTCCCAACCCATCTACCAGAAC AACAACGCTCCCAGCAAGCCCACTGCAGCCAAGATCCTGGGAAAGGTGGGAGAAAGCCTG AGCCGGATCTGCTGTGTCCGCCCGCCAGTGGAGCGTTTCACCTTTGTGGATGAGAATGCC AACCTGGGCACGGTGATGCGGTACGAGGAGATCGAGCTACGGATCTTGCTGCTGTGTGGC AGTGACCTTCTGGAGTCCTTCTGCATCCCAGGACTGTGGAACGAGGCAGATATGGAGGTG ATCGTTGGGGACTTTGGGATCGTGGTGGTCCCCCGGGACGCAGCCGACACAGACCGAATC ATGAACCACTCTTCAATACTCCGCAAATACAAAAATAACATCATGGTGGTGAAGGATGAC ATCAACCATCCCATGTCTGTGGTCAGCTCAACCAAGAGCAGGCTGGCTCTGCAGCACGGG GATGGCCACGTCGTGGATTACCTGTCCCAGCCGGTCATCGACTACATTCTCAAGAGCCAG CTGTACATCAACGCCTCGGGCTAG |
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| Protein Properties | |||||
| Number of Residues | 307 | ||||
| Molecular Weight | 34468.0 | ||||
| Theoretical pI | 7.28 | ||||
| Pfam Domain Function | Not Available | ||||
| Signals |
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| Transmembrane Regions | Not Available | ||||
| Protein Sequence |
>Nicotinamide mononucleotide adenylyltransferase 2 MTETTKTHVILLACGSFNPITKGHIQMFERARDYLHKTGRFIVIGGIVSPVHDSYGKQGL VSSRHRLIMCQLAVQNSDWIRVDPWECYQDTWQTTCSVLEHHRDLMKRVTGCILSNVNTP SMTPVIGQPRNETSQPIYQNNNAPSKPTAAKILGKVGESLSRICCVRPPVERFTFVDENA NLGTVMRYEEIELRILLLCGSDLLESFCIPGLWNEADMEVIVGDFGIVVVPRDAADTDRI MNHSSILRKYKNNIMVVKDDINHPMSVVSSTKSRLALQHGDGHVVDYLSQPVIDYILKSQ LYINASG |
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| External Links | |||||
| GenBank ID Protein | AAI20345.1 | ||||
| UniProtKB/Swiss-Prot ID | Q0VC59 | ||||
| UniProtKB/Swiss-Prot Entry Name | NMNA2_BOVIN | ||||
| PDB IDs | Not Available | ||||
| GenBank Gene ID | BC120344 | ||||
| GeneCard ID | NMNAT2 | ||||
| GenAtlas ID | Not Available | ||||
| HGNC ID | Not Available | ||||
| References | |||||
| General References | Not Available | ||||