| Identification |
|---|
| BMDB Protein ID
| BMDBP00109 |
| Secondary Accession Numbers
| None |
| Name
| N-acetylneuraminate lyase |
| Synonyms
|
Not Available
|
| Gene Name
| NPL |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Amino acid transport and metabolism |
| Specific Function
| Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway (By similarity). |
| Pathways
|
- Amino Sugar Metabolism
- Amino-sugar metabolism
- N-acetylneuraminate degradation
|
| Reactions
|
| N-Acetylneuraminic acid → N-Acetyl-D-mannosamine + Pyruvic acid |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 16 |
| Locus
| Not Available |
| SNPs
| NPL |
| Gene Sequence
|
>963 bp
ATGGCCTCCCCAAAGAAGAAGCTCCAAGGTCTTGTTGCTGCGACCATCACGCCGATGACT
GAGCATGGAGAAATCAACTTTTCAGTCATTGGTCGGTATGTGGACTATCTTGTAGAGGAA
CAGGGAGTGAAGAATGTCTTTGTGAACGGCACGACGGGAGAAGGCCTGTCCCTGAGCATC
TCGGAGCGCTGCCAGGTCGCAGAGGAGTGGGTGACAAAGGGGAAGAACAAGTTGGATCAG
ATAGTAATTCATGTGGGAGCCTTGAGCTTGAAGGAGTCACAAGAACTGGCCCAACATGCA
GCAGAAATAGGAGCCGACGGCATCGCTGTCATCGCACCTTTCTTTCTCAAGCCATGGAAC
AAAGATGTCCTAATTAATTTCCTAAAAGAAGTGGCTGCTGCTGCCCCTGCATTGCCGTTT
TACTACTATCACATCCCTGCCTTGACCGGGGTGAAGATTCGTGCTGAGGAACTGTTGGAT
GGGATTCAGGATAAGATCCCCAGCTTCCAAGGGCTGAAATTCAGTGACACGGATCTCTTA
GACTTCGGGCAGTGTGTGGATCAGAATCGCCAGCGACAGTTTGCTTTCCTTTTTGGGGTG
GATGAGCAACTGTTAAGTGCTCTGGTGATGGGAGCAACTGGAGCGGTGGGCAGTACCTAT
AACTACCTGGGAAAAAAGACAAAGCAGATGTTGGAGGCTTTTGAACGAAAGGACTTCTCT
TCAGCTCTGAACCATCAGTTTTGTATTCAGAGATTTATCAACTTTGTGGTCAAACTAGGT
TTTGGAGTGTCGCAGACCAAAGCCATCATGACCCTTGTCTCCGGGATTCCAATGGGCCCA
CCCCGTCTTCCGCTACAGAAAGCCTCCAGGGAGTTTACTGATAATGCAGAAGCTAAACTG
AAAAGCCTAGATTTCCTTTCTTGCACTGATTTAAAGGATGGAAATATGGAAGCTTGTAGC
TAG
|
| Protein Properties |
|---|
| Number of Residues
| 320 |
| Molecular Weight
| 35166.0 |
| Theoretical pI
| 6.37 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>N-acetylneuraminate lyase
MASPKKKLQGLVAATITPMTEHGEINFSVIGRYVDYLVEEQGVKNVFVNGTTGEGLSLSI
SERCQVAEEWVTKGKNKLDQIVIHVGALSLKESQELAQHAAEIGADGIAVIAPFFLKPWN
KDVLINFLKEVAAAAPALPFYYYHIPALTGVKIRAEELLDGIQDKIPSFQGLKFSDTDLL
DFGQCVDQNRQRQFAFLFGVDEQLLSALVMGATGAVGSTYNYLGKKTKQMLEAFERKDFS
SALNHQFCIQRFINFVVKLGFGVSQTKAIMTLVSGIPMGPPRLPLQKASREFTDNAEAKL
KSLDFLSCTDLKDGNMEACS
|
| External Links |
|---|
| GenBank ID Protein
| AAI13333.1 |
| UniProtKB/Swiss-Prot ID
| Q29RY9 |
| UniProtKB/Swiss-Prot Entry Name
| NPL_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC113332 |
| GeneCard ID
| NPL |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
