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| Identification |
|---|
| BMDB Protein ID
| BMDBP00118 |
| Secondary Accession Numbers
| |
| Name
| Monofunctional C1-tetrahydrofolate synthase, mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| MTHFD1L |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Nucleotide transport and metabolism |
| Specific Function
| May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2. |
| Pathways
|
- One-carbon metabolism
- Tetrahydrofolate interconversion
|
| Reactions
|
| 5,10-Methenyltetrahydrofolic acid + NADPH → 5,10-Methylene-THF + NADP |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 9 |
| Locus
| Not Available |
| SNPs
| MTHFD1L |
| Gene Sequence
|
>2928 bp
ATGAGCGCGCGCCTGCCGTTCGTCCTGCGCCGGCTCGCGCGCCCGCAGCACCCCGGCTCG
CCGCGCCGCCTCCCATCTCTTTGTCGCGCCAGCAGCGGCAGGGGCAGCGGATGTGGCGGC
GGGGAGGGTCTCCTCGGGCAACAGCGGCTGCGGGATACCCAGGCCGGGAGCAGCCGGGGC
CCGGGCAGCCCGGCGCCCCCAGCTCGGGACTCGATCGTCCGAGAAGTCATTCAGAATTCG
AAAGAAGTTCTGAGTTTATTGCAAGAAAAGACCCCTACCTTTAAGCCGGTTCTTGCTATT
ATTCAGGCAGGTGATGATAACTTGATGCAAGAAGTAAACCAGAATTTGGCTGAGGAGGCT
GGTCTGAACATCACCCACATCTGCCTTCCTGCGGAGAGCGGGGAAGATGAGATTATAGAT
GAGATCCTGAAGATTAATGAAGACAGCAGAGTACATGGCCTTGCCCTTCAGATCGCTGAG
ACCTCATTTAGCAACAAAATCCTCAATGCTTTGAAACCAGAAAAAGATGTGGATGGATTA
ACGGATGTCAACCTGGGGAAGTTGGTCCGAGGAGATGCCCATGGGTGTTTTATTTCACCT
GTGGCCAGAGCTGTAATCGAACTTCTTGAAAAGTCAGGTGTCAGCTTAGATGGAAAGAAG
ATCTTGGTAATAGGAGCCCATGGGTCTTTGGAAGCCACCCTACAATGTCTGTTCCAGAGA
AAAGGGTCCATGACAATGAGCTCCCAGTGGAAAACACCTCAGCTTCAAGGCAAGCTACAG
GAGGCTGATATTGTGGTCTTGGGCTCACCCAAGCCAGAAGAGATCCCCCTTTCTTGGATT
CAACCGGGAACTACTGTTTTCAACTGTTCGCATGACTTTCTATCAGGGAAGGCTGCATGC
ATTTCTTCTGGCGTCCATGGTATTAGTCCCATCGCCGAAGATGTGAGTCTCCTTGCTGCT
GCTCTGCGGATTCAGAACATGGTCAGCAGCGGAAGGAGATGGCTCCGTGAGCAGCAGCAC
CGCAGATGGAGACTTCACTGCTTGAAACTTCAGCCTCTGTCCCCTGTACCAAGTGATATC
GAGATTTCGAGAGCGCAGACTCCAAAAGCTGTGGAGATCCTTGCCAAGGAGATAGGATTG
CTTGCAGACGAAATTGAAATCTATGGCAAAAGCAAAGCCAAAGTACGTTTGTCCTTGTTG
GAAAGGTTAAAGGATCAAGCAGATGGAAAATACGTCTTGGTTGCTGGGATCACACCCACC
CCTCTTGGAGAAGGAAAAAGTACAGTTACAATTGGGCTTGTACAGGCATTGACTGCGCAC
CTGAACGTCAACTCCTTTGCCTGTCTCAGGCAGCCTTCTCAAGGACCAACTTTCGGAGTT
AAAGGAGGAGCTGCAGGTGGTGGATATGCCCAGGTCATCCCTATGGAGGAGTTCAACCTT
CACCTTACTGGGGACATCCACGCCATTACTGCTGCCAATAATTTGCTGGCTGCCGCTATC
GACGCAAGGATTTTGCATGAAAACACTCAAACAGATAAGGCCCTGTATAATCGACTGGTT
CCTTCAGTGAATGGTGTTCGAGAATTTTCAAAAATTCAACTTGCTCGGCTGAAAAGACTG
GGAATAAATAAGACTGATCCGAGTGCGCTGACAGAAGAGGAAATGAGGAAATTTGCCCGT
CTTGACATCGACCCCTCCACCATCACATGGCAGAGAGTTGTGGATACCAATGACCGATTT
CTACGGAAAATAACCATTGGGCAGGCGAACACAGAGAAGGGCTGTTCCCGGCAGGCGCAG
TTTGACATCGCAGTGGCCAGTGAAATCATGGCAGTGCTGGCTCTGACCGACAGCCTATCG
GACATGAAGGAGCGGCTGGGAAGAATGGTGGTGGCCAGTGACAGAAATGGACAGCCTGTG
ACAGCAGACGACTTGGGGGTGACAGGTGCTTTGACTGTTCTGATGAAAGACGCGATAAAA
CCAAATCTGATGCAGACCCTAGAAGGGACGCCTGTATTTGTGCATGCTGGCCCCTTTGCC
AACATCGCTCATGGCAACTCTTCAGTGTTGGCTGATAAAATTGCCCTGAAACTGGTTGGG
GAAGGAGGATTTGTGGTGACTGAAGCTGGCTTTGGTGCTGATATTGGCATGGAGAAATTC
TTCAACATCAAGTGCAGAGCTTCTGGTTTGGTGCCCAGCGTTGTGGTTCTGGTGGCGACC
GTGCGGGCTCTGAAGATGCATGGAGGTGGACCGAGCGTAACTGCTGGGGTCCCTCTTAGA
AAGGAATATACCGAAGAGAACCTCCAGCTGGTGGCAGATGGCTGCTGTAACCTGGAGAAG
CAAATTCAGATCGCTCAGCTCTTCGGGGTCCCTGTTGTTGTGGCTCTGAATGTCTTCAAG
ACCGACACCCGCGCAGAGATTGACTTGGTGTGTGAGCTTGCGAAGCGGGCCGGCGCCTTC
AATGCAGTCCCCTGCTATCACTGGTCGATTGGTGGGAAAGGGTCAGTGGACCTGGCTTGG
GCTGTGAGAGAAGCTGCAAGCAAAGAAAGTCGTTTCCAGTTCCTGTATGATGTGCAGCTT
CCAATTGTGGAAAAGATAAGAACCATTGCCCAGTCTGTCTATGGAGCCAAAGATATTGAA
CTCTCTCCAGAAGCACAATCCAAAATAGATCGTTACACGGAACAGGGATTTGGAAATTTG
CCCATCTGCATGGCGAAGACCCACCTCTCCCTGTCTCACCAACCTGACAAGAAAGGCGTA
CCCAAGGGTTTCATTCTACCCATTAGTGACGTCCGGGCCAGCATAGGCGCCGGATTCATT
TACCCATTGGTTGGAACGATGAGCACCATGCCAGGACTGCCAACTCGGCCCTGCTTCTAC
GACATAGATCTTGATACAGAAACAGAGCAGGTTAAAGGCTTGTTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 975 |
| Molecular Weight
| 105227.0 |
| Theoretical pI
| 7.78 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Monofunctional C1-tetrahydrofolate synthase, mitochondrial
MSARLPFVLRRLARPQHPGSPRRLPSLCRASSGRGSGCGGGEGLLGQQRLRDTQAGSSRG
PGSPAPPARDSIVREVIQNSKEVLSLLQEKTPTFKPVLAIIQAGDDNLMQEVNQNLAEEA
GLNITHICLPAESGEDEIIDEILKINEDSRVHGLALQIAETSFSNKILNALKPEKDVDGL
TDVNLGKLVRGDAHECFISPVARAVIELLEKSGVSLDGKKILVIGAHGSLEATLQCLFQR
KGSMTMSSQWKTPQLQGKLQEADIVVLGSPKPEEIPLSWIQPGTTVFNCSHDFLSGKAAC
ISSGVHGISPIAEDVSLLAAALRIQNMVSSGRRWLREQQHRRWRLHCLKLQPLSPVPSDI
EISRAQTPKAVEILAKEIGLLADEIEIYGKSKAKVRLSLLERLKDQADGKYVLVAGITPT
PLGEGKSTVTIGLVQALTAHLNVNSFACLRQPSQGPTFGVKGGAAGGGYAQVIPMEEFNL
HLTGDIHAITAANNLLAAAIDARILHENTQTDKALYNRLVPSVNGVREFSKIQLARLKRL
GINKTDPSALTEEEMRKFARLDIDPSTITWQRVVDTNDRFLRKITIGQANTEKGCSRQAQ
FDIAVASEIMAVLALTDSLSDMKERLGRMVVASDRNGQPVTADDLGVTGALTVLMKDAIK
PNLMQTLEGTPVFVHAGPFANIAHGNSSVLADKIALKLVGEGGFVVTEAGFGADIGMEKF
FNIKCRASGLVPSVVVLVATVRALKMHGGGPSVTAGVPLRKEYTEENLQLVADGCCNLEK
QIQIAQLFGVPVVVALNVFKTDTRAEIDLVCELAKRAGAFNAVPCYHWSIGGKGSVDLAW
AVREAASKESRFQFLYDVQLPIVEKIRTIAQSVYGAKDIELSPEAQSKIDRYTEQGFGNL
PICMAKTHLSLSHQPDKKGVPKGFILPISDVRASIGAGFIYPLVGTMSTMPGLPTRPCFY
DIDLDTETEQVKGLF
|
| External Links |
|---|
| GenBank ID Protein
| AAI20039.1 |
| UniProtKB/Swiss-Prot ID
| Q0VCR7 |
| UniProtKB/Swiss-Prot Entry Name
| C1TM_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC120038 |
| GeneCard ID
| MTHFD1L |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
