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Showing Protein Dimethylaniline monooxygenase [N-oxide-forming] 3 (BMDBP00119)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00119 |
| Secondary Accession Numbers | None |
| Name | Dimethylaniline monooxygenase [N-oxide-forming] 3 |
| Synonyms | Not Available |
| Gene Name | FMO3 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Inorganic ion transport and metabolism |
| Specific Function | Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation. |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 16 |
| Locus | Not Available |
| SNPs | FMO3 |
| Gene Sequence |
>1599 bp ATGGTGAAGAAAGTGGCCATCATTGGAGCAGGCATCAGTGGCCTGGCCTCCATCAGAAAC TGCCTAGAAGAGGGACTGGAACCCACCTGCTTTGAGAAGGGTGAAGACATTGGGGGCCTG TGGAAATTCTCGGACCATGTAGAGGAAGGCAGGGCCAGCATTTATCGGTCAGTCTTTACC AACTCTTCCAAAGAGATGACATGTTTTCCAGACTTTCCATTTCCTGATGATTTTCCTAAC TTTATGCACAACAGCAAGCTCCAGGAATATATTACTATGTTTGCCAAAGAAAAGAACCTC CTGAAATACATACAATTTAAGACAATTGTATCCAGTGTAAATAAGCGTCCCGATTTCCAA ACCACTGGCCAATGGGATGTTATCACTGAAAAGGATGGTAAAAAGGAATCAGCTGTCTTT GATGCCGTAATGATTTGTTCTGGACATCATGTGTACCCCAACATACCTAAAGAGTCCTTT CCAGGAATAAAACTTTTTAAAGGCAAATGCTTCCACAGCCGGGACTATAAAGAACCAGGA ATCTTCAAGGGGAAGCGAGTCCTGGTGATTGGTCTGGGGAACTCAGGCTGTGACATCGCC TCAGAACTCAGCCACATAGCTGAAAAAGTCATCATCAGCTCCCGAAGTGGCTCCTGGGTG ATGAGCCGGGTCTGGGATGAAGGCTATCCATGGGACATGCTGTTTATCACTCGATTTGAA ACATTCCTCAAGAACACCTTACCGACAGTCATTTCTAACTGGTGGTACATGAAGCAAATG AACGCCAGATTCAAGCACGAGAACTACGGCTTGATGCCTTTAAACAGCACCCTGAGGAAA GAGCCTGTGTTCAATGACGAACTCCCAGCTTGCATTTTATGTGGCATTGTGACCATTAAG CCAAATGTGAAGGAGTTTACAGAGGATTCAGCTATTTTTGAGGATGGGACGGTGTTTAAG GCCATTGACTATGTCATCTTTGCAACAGGCTATAGTTATGCCTACCCCTTCCTTGATGAC TCCATCATTAAGAGCAGAGACAATGAGGTCACCTTATTTAAAGGCATCTTCCCACCTCCA CTGGAAAAGCCAACCTTGGCTGTGATCGGCCTTGTCCAGTCCCTTGGAGCTGCCATCCCC ACTACTGACCTGCAGTCTCGCTGGGCAGTACAAGTAATTAAGGGAACATGCCCTTTGCCT TCTGTCAAGGACATGATGAATGATATTGATGAAAAAATGGGGAAAAAGCTCAAATTGTTT GGCAAAAGTGATACCATACAGACGGATTATGTTGTTTATATGGATGAGCTTGCCTCCTTC ATTGGGGCAAAGCCCAACATCCCATGGCTGTTTCTCACAGATCCAAAGTTGGCATTGGAG GTCTACTTTGGCCCTTGCACCCCATACCAGTTTAGGCTGGTGGGCCCAGGAAAGTGGCCA GGAGCCAGAAACGCCATCCTGACCCAGTGGGACCGGTTACTGAAACCTATGACGACAAGA GTGGTTGGGAGTCCTCTGAAGCCTTGCTTATTTTGCAACTGGTTCAGACCTGTTCTTATT TCTGTTGTATCAATTGCTGCTCTCATTGTGTTGTTCTAG |
| Protein Properties | |
| Number of Residues | 532 |
| Molecular Weight | 60093.0 |
| Theoretical pI | 8.14 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions |
|
| Protein Sequence |
>Dimethylaniline monooxygenase [N-oxide-forming] 3 MVKKVAIIGAGISGLASIRNCLEEGLEPTCFEKGEDIGGLWKFSDHVEEGRASIYRSVFT NSSKEMTCFPDFPFPDDFPNFMHNSKLQEYITMFAKEKNLLKYIQFKTIVSSVNKRPDFQ TTGQWDVITEKDGKKESAVFDAVMICSGHHVYPNIPKESFPGIKLFKGKCFHSRDYKEPG IFKGKRVLVIGLGNSGCDIASELSHIAEKVIISSRSGSWVMSRVWDEGYPWDMLFITRFE TFLKNTLPTVISNWWYMKQMNARFKHENYGLMPLNSTLRKEPVFNDELPACILCGIVTIK PNVKEFTEDSAIFEDGTVFKAIDYVIFATGYSYAYPFLDDSIIKSRDNEVTLFKGIFPPP LEKPTLAVIGLVQSLGAAIPTTDLQSRWAVQVIKGTCPLPSVKDMMNDIDEKMGKKLKLF GKSDTIQTDYVVYMDELASFIGAKPNIPWLFLTDPKLALEVYFGPCTPYQFRLVGPGKWP GARNAILTQWDRLLKPMTTRVVGSPLKPCLFCNWFRPVLISVVSIAALIVLF |
| External Links | |
| GenBank ID Protein | AAN27919.1 |
| UniProtKB/Swiss-Prot ID | Q8HYJ9 |
| UniProtKB/Swiss-Prot Entry Name | FMO3_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | AF488422 |
| GeneCard ID | FMO3 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |