| Identification |
|---|
| BMDB Protein ID
| BMDBP00121 |
| Secondary Accession Numbers
| None |
| Name
| Glutaryl-CoA dehydrogenase, mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| GCDH |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Lipid transport and metabolism |
| Specific Function
| Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor (By similarity). |
| Pathways
|
- Amino-acid metabolism
- Fatty Acid Metabolism
- Lysine Degradation
- Lysine degradation.
- Tryptophan Metabolism
|
| Reactions
|
| Glutaryl-CoA → Crotonoyl-CoA + Carbon dioxide |
details
|
| Glutaryl-CoA + electron-transfer flavoprotein → Crotonoyl-CoA + Reduced electron-transfer flavoprotein + Carbon dioxide |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 7 |
| Locus
| Not Available |
| SNPs
| GCDH |
| Gene Sequence
|
>1317 bp
ATGGCCCTGAGAGGCGTCTACGCGCAACTACTGAACCGCGGACCCGGCCTACGAGTCTTT
CGTTCATGGAGCTCGGCGACAGCGCAGACCGAGAAAGGCGAGAAGACCCAGAGTCGATCG
GCCAAGCCTTCGCGGCCTGAGTTTGACTGGAGGGATCCACTGTTGCTGGAGGAGCAGCTG
ACAGCAGATGAGATCCTCATCAGGGACACCTTCCGCACCTACTGCCAGGAGCGCCTCATG
CCCCGCATCCTGCTGGCCAATCGCAACGAAGTTTTTCACCGGGAGATCATCTCAGAGATG
GGGGAGCTCGGTATGCTGGGCCCCACCATCCAAGGGTATAGTTGTGCTGGAGTCTCATCG
GTGGCCTACGGGCTCCTAGCCCGAGAGCTGGAGCGAGTGGACAGCGGCTACAGGTCAGCA
ATGAGTGTCCAGTCTTCCCTTGTCATGTACCCTATCTATGCGTATGGCAGCGAGGAGCAG
AAGCAGAAGTACCTGCCCCGGCTGGCCAAGGGGGAGCTGCTGGGCTGCTTTGGGCTCACG
GAGCCCAACCACGGGAGTGACCCTAGTGGCATGGAGACCAGAGCCCGCCACAACCCATCC
AGCAGGAGCTACATCCTCAGTGGGTCCAAGACCTGGATCACCAACTCGCCTGTGGCCGAC
TTGCTGATAGTATGGGCTCGGTGTGAGGATAGCTGCATTCGGGGCTTCCTGCTGGAGAAG
GGGATGCGGGGCCTCTCAACCCCCAGGATTGAGGGCAAGTTCTCTCTGCGGGCATCATCC
ACAGGGATGATTATTATGGATGATGTGGAGGTGCCAGAGGAGAATGTGCTGCCCGGGGTG
TCTGGTCTGGCGGGTCCCTTCGGCTGCCTAAACAATGCCCGCTATGGCATCACATGGGGT
GTGCTTGGAGCTGCTGAATTCTGTTTGCACACGGCCCGGCAGTACACTCTGGACAGGATC
CAGTTTGGTGTCCCACTGGCCAAGAACCAACTGATTCAGAAAAAGCTGGCAGACATGCTC
ACCGAGATCACGTTGGGCCTCCATGCCTGCCTGCAGCTCGGCCGCTTGAAGGATCAAGAC
AAGGCCGCCCCGGAAATGGTCTCTTTGCTGAAGAGGAATAACTGTGGGAAGGCCCTGGAC
ATTGCTCGCCAGGCCCGAGACATGCTTGGGGGGAATGGGATTTCTGATGAGTATCACGTG
ATCCGGCATGTCATGAACCTGGAGTCTGTGAACACCTATGAAGGTACTCATGACATCCAT
GCTCTGATCCTTGGAAGGGCTATCACAGGGATCCAGGCGTTCGTGGCCGGCAAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 438 |
| Molecular Weight
| 48472.0 |
| Theoretical pI
| 8.14 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Glutaryl-CoA dehydrogenase, mitochondrial
MALRGVYAQLLNRGPGLRVFRSWSSATAQTEKGEKTQSRSAKPSRPEFDWRDPLLLEEQL
TADEILIRDTFRTYCQERLMPRILLANRNEVFHREIISEMGELGMLGPTIQGYSCAGVSS
VAYGLLARELERVDSGYRSAMSVQSSLVMYPIYAYGSEEQKQKYLPRLAKGELLGCFGLT
EPNHGSDPSGMETRARHNPSSRSYILSGSKTWITNSPVADLLIVWARCEDSCIRGFLLEK
GMRGLSTPRIEGKFSLRASSTGMIIMDDVEVPEENVLPGVSGLAGPFGCLNNARYGITWG
VLGAAEFCLHTARQYTLDRIQFGVPLAKNQLIQKKLADMLTEITLGLHACLQLGRLKDQD
KAAPEMVSLLKRNNCGKALDIARQARDMLGGNGISDEYHVIRHVMNLESVNTYEGTHDIH
ALILGRAITGIQAFVAGK
|
| External Links |
|---|
| GenBank ID Protein
| AAI12823.1 |
| UniProtKB/Swiss-Prot ID
| Q2KHZ9 |
| UniProtKB/Swiss-Prot Entry Name
| GCDH_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BC112822 |
| GeneCard ID
| GCDH |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
