| Identification |
|---|
| BMDB Protein ID
| BMDBP00123 |
| Secondary Accession Numbers
| |
| Name
| Macrophage migration inhibitory factor |
| Synonyms
|
Not Available
|
| Gene Name
| MIF |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in cytokine activity |
| Specific Function
| Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity (By similarity). |
| Pathways
|
Not Available
|
| Reactions
|
| 4-Hydroxyphenylpyruvic acid → 2-Hydroxy-3-(4-hydroxyphenyl)propenoic acid |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 17 |
| Locus
| Not Available |
| SNPs
| MIF |
| Gene Sequence
|
>348 bp
ATGCCGATGTTCGTGGTGAACACCAACGTGCCCCGCGCCTCCGTGCCGGACGGGCTCCTC
TCCGAGCTCACGCAGCAGCTGGCGCAGGCCACGGGCAAGCCGGCACAGTACATCGCGGTG
CACGTGGTCCCAGACCAGCTCATGACCTTCGGGGGCTCCAGCGAGCCCTGCGCGCTCTGC
AGCCTGCACAGCATCGGCAAGATCGGCGGCGCGCAGAACCGCTCCTACAGCAAGCTGCTG
TGCGGCCTGCTGACCGAGCGCCTGCGCATTAGCCCGGACAGGATCTACATCAACTTCTGC
GACATGAACGCGGCCAACGTGGGCTGGAACGGCTCCACCTTCGCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 115 |
| Molecular Weight
| 12343.0 |
| Theoretical pI
| 7.94 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Macrophage migration inhibitory factor
MPMFVVNTNVPRASVPDGLLSELTQQLAQATGKPAQYIAVHVVPDQLMTFGGSSEPCALC
SLHSIGKIGGAQNRSYSKLLCGLLTERLRISPDRIYINFCDMNAANVGWNGSTFA
|
| External Links |
|---|
| GenBank ID Protein
| AAI02067.1 |
| UniProtKB/Swiss-Prot ID
| P80177 |
| UniProtKB/Swiss-Prot Entry Name
| MIF_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC102066 |
| GeneCard ID
| MIF |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
