| Identification |
|---|
| BMDB Protein ID
| BMDBP00125 |
| Secondary Accession Numbers
| |
| Name
| L-dopachrome tautomerase |
| Synonyms
|
Not Available
|
| Gene Name
| DCT |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in dopachrome isomerase activity |
| Specific Function
| Catalyzes the conversion of L-dopachrome into 5,6-dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels. |
| Pathways
|
- Melanin biosynthesis
- Pigment biosynthesis
|
| Reactions
|
| L-Dopachrome → 5,6-Dihydroxyindole-2-carboxylic acid |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 12 |
| Locus
| 12q23 |
| SNPs
| DCT |
| Gene Sequence
|
>1554 bp
ATGAGCCCCCTTGGGTGGGGGCTTCTGCTCGGCTGTCTGGGTTGTGCGCTCCCGTCGGGG
GCCCGGGCGCAGTTCCCCAGGGTCTGCATGACGGTGGGCAGCCTGCAGGCCAAGGAATGC
TGCCCGCCGCTGGGCGCCGACCCCGCCAACGTCTGCGGCTCCCGGGAGGGCCGGGGCCAG
TGCGCGGAGGTGCAGACCGACACCAGGCCCTGGAGCGGTCCCTACGTCCTGCGCAACCAG
GACGACCGAGAGCGATGGCCCCGGAAGTTCTTCGACCGGACCTGCAGGTGCACAGGAAAC
TTCGCCGGCTATAACTGTGGAAACTGCAGGTTTGGCTGGACCGGACCCAAATGCGATCAG
AAGAAACCATTGGTTGTCCGGCGAGATGTCCATTCCTTGACCCCTCAAGAGAGGGAGCAA
TTCTTGGACGCCTTAGACCTCGCAAAGTACACTCCGCACCCCGACTACGTGATCACCACG
CAACACTGGCTGGGCCTCCTGGGGCCCAATGGGACCCAACCACAGATCGCCAACTGCAGC
ATTTATGATTTCTTTGTGTGGCTCCATTATTATTCCGTCAGAGATACATTATTAGGACCA
GGGCGCCCATACAAGGCTATAGATTTCTCACACCAAGGACCTGCTTTTGTTACCTGGCAC
CGGTACCACTTGTTATGGCTGGAAAGGGATCTCCAGCGCCTTACTGGCAATGAGTCCTTC
GCTTTGCCCTACTGGAACTTTGCCACCGGCAGGAACGAGTGTGACGTGTGCACGGACCAG
CTGCTCGGGGCAGCAAGGCAAGACGATCCGACTCTGATTAGTCAGAACTCCCGATTCTCC
AGCTGGGAGATTGTCTGTGATAGCTTGAATGACTACAACCGCCGAGTCACCTTGTGTAAT
GGAACCTATGAAGGTTTGTTGAAAAGAAATCAAATGGGAAGAAACAGTGAAAAATTGCCA
ACTTTAAAAGACATACAAAATTGCCTGTCTCTCAAGAAGTTTGACAGTCCTCCTTTCTTC
CAGAACTCTACCCTCAGTTTCAGGAATGCCCTGGAAGGGTTTGGCAAAGCAGATGGGACC
CTGGACTCTCAAGTGATGAATTTTCATAATCTGGTTCATTCCTTCCTGAATGGGACAAGC
GCTTTGCCACATTCTGCTGCCAATGATCCTGTTTTTGTGGTCCTTCATTCCTTCACTGAT
GCCATTTTTGACGAGTGGATGAAAAGATTCAATCCCCCTGTGGATGCCTGGCCTCGGGAG
CTGGCACCCATTGGTCACAATCGGATGTATAACATGGTTCCTTTCTTCCCTCCGGTGACT
AATGAGGAACTCTTTTTAACCGCAGACCAACTTGGCTACAGTTATGCCATTGATCTGCCA
GTTGAAGAAACTCCAGATTGGACCACAGTGCTCTCAGTGGTTACGGGGATGCTCGTGGTT
TTGGTTGTCCTTTTTGCATTGCTTCTTTTCCTTCAATATAGACGACTTCGAAAAGGGTAT
ACACCCTTAGTGGAGACACAGCTAAGCAACAAAAGATACACCGAAGAAGCCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 517 |
| Molecular Weight
| 58787.0 |
| Theoretical pI
| 7.22 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>L-dopachrome tautomerase
MSPLGWGLLLGCLGCALPSGARAQFPRVCMTVGSLQAKECCPPLGADPANVCGSREGRGQ
CAEVQTDTRPWSGPYVLRNQDDRERWPRKFFDRTCRCTGNFAGYNCGNCRFGWTGPKCDQ
KKPLVVRRDVHSLTPQEREQFLDALDLAKYTLHPDYVITTQHWLGLLGPNGTRPQIANCS
IYDFFVWLHYYSVRDTLLGPGRPYKAIDFSHQGPAFVTWHRYHLLWLERDLQRLTGNESF
ALPYWNFATGRNECDVCTDQLLGAARQDDPTLISQNSRFSSWEIVCDSLNDYNRRVTLCN
GTYEGLLKRNQMGRNSEKLPTLKDIQNCLSLKKFDSPPFFQNSTLSFRNALEGFGKADGT
LDSQVMNFHNLVHSFLNGTSALPHSAANDPVFVVLHSFTDAIFDEWMKRFNPPVDAWPRE
LAPIGHNRMYNMVPFFPPVTNEELFLTADQLGYSYAIDLPVEETPDWTTVLSVVTGMLVV
LVVLFALLLFLQYRRLRKGYTPLVETQLSNKRYTEEA
|
| External Links |
|---|
| GenBank ID Protein
| AAP33051.1 |
| UniProtKB/Swiss-Prot ID
| Q95119 |
| UniProtKB/Swiss-Prot Entry Name
| TYRP2_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AY278108 |
| GeneCard ID
| DCT |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
