| Identification |
|---|
| BMDB Protein ID
| BMDBP00127 |
| Secondary Accession Numbers
| None |
| Name
| Deoxyhypusine synthase |
| Synonyms
|
Not Available
|
| Gene Name
| DHPS |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Posttranslational modification, protein turnover, chaperones |
| Specific Function
| Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a critical lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. This is the first step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function. |
| Pathways
|
- EIF5A hypusination
- Protein modification
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 7 |
| Locus
| Not Available |
| SNPs
| DHPS |
| Gene Sequence
|
>1110 bp
ATGGAGGGTCCCCAGGAGAGGGAGGTGCCGGCGCCGGCACTGGCCGCCGTGCTGAAGCAC
AGTTCGGCACTGCCGTTCGAGACCGCGCAGGTGCGGGGCTACGACTTCAACCGTGGCGTG
GACTATCGCGCACTGCTAGAGGCTTTCAGCACCACTGGTTTCCAAGCCACCAACTTCGGG
CGCGCGGTACAGCAAGTCAACGCCATGATAGAGAAGAAACTCGAGCCGCTATCCGAGGAT
GAAGACCAACATGCAGACTTGACCCAGAGCCGACGCCCACTCACCGGCTGCACCATTTTT
CTGGGCTACACATCCAACCTCATCAGTTCAGGCATCCGTGAGACTATCCGTTACCTCGTG
CAGCACAACATGGTGGACGTCTTGGTGACCACAGCTGGGGGTGTGGAGGAGGATTTCATC
AAGTGCTTGGCGCCCACATACCTGGGCGAGTTCAGCCTCAGGGGGAAGGAGCTACGTGAG
AACGGGATCAACAGGATTGGAAACTTGCTGGTGCCCAATGACAATTACTGCAAGTTTGAG
GACTGGTTGATGCCCATTCTGGACCAGATGGTGCTGGAGCAGAACACAGAGGGTGTGAAG
TGGACACCTTCCAAGATGATCGCCCGGCTTGGCAAGGAGATAAACAACCCAGAGTCCGTG
TATTACTGGGCCCAGAAGAACCATATTCCTGTGTTGAGCCCGGCACTCACAGATGGCTCG
CTGGGTGACATGATCTTCTTCCACTCCTATAAGAACCCAGGTCTGGTCCTGGACATTGTT
GAGGACCTCAAGCTCATCAACACACAGGCCATCTTCGCCAAGCGTACGGGGATGATCATC
CTGGGTGGTGGCATGGTCAAGCACCACATCGCCAATGCCAACCTCATGCGGAATGGCGCT
GACTATGCCGTCTACATCAACACTGCCCAGGAGTTTGATGGCTCTGACTCAGGCGCCCGG
CCAGATGAAGCTGTCTCATGGGGCAAGATCCGGATGGATGCACAGCCTGTCAAGGTCTAT
GCTGATGCCTCCTTGGTCTTCCCGCTGCTTGTGGCTGAAACCTTTGCCCAGAAGGTAGAT
GCCTTCACGCCCGAGAAGAATGAGGACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 369 |
| Molecular Weight
| 41029.0 |
| Theoretical pI
| 4.85 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Deoxyhypusine synthase
MEGPQEREVPAAALAAVLKHSSALPFETAQVRGYDFNRGVDYRALLEAFSTTGFQATNFG
RAVQQVNAMIEKKLEPLSEDEDQHADLTQSRRPLTGCTIFLGYTSNLISSGIRETIRYLV
QHNMVDVLVTTAGGVEEDFIKCLAPTYLGEFSLRGKELRENGINRIGNLLVPNDNYCKFE
DWLMPILDQMVLEQNTEGVKWTPSKMIARLGKEINNPESVYYWAQKNHIPVLSPALTDGS
LGDMIFFHSYKNPGLVLDIVEDLKLINTQAIFAKRTGMIILGGGMVKHHIANANLMRNGA
DYAVYINTAQEFDGSDSGARPDEAVSWGKIRMDAQPVKVYADASLVFPLLVAETFAQKVD
AFMPEKNED
|
| External Links |
|---|
| GenBank ID Protein
| CAE12195.1 |
| UniProtKB/Swiss-Prot ID
| Q6EWQ6 |
| UniProtKB/Swiss-Prot Entry Name
| DHYS_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| AJ577610 |
| GeneCard ID
| DHPS |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
