Showing Protein Deoxyhypusine synthase (BMDBP00127)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00127 |
| Secondary Accession Numbers | None |
| Name | Deoxyhypusine synthase |
| Synonyms | Not Available |
| Gene Name | DHPS |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Posttranslational modification, protein turnover, chaperones |
| Specific Function | Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a critical lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. This is the first step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function. |
| Pathways |
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| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 7 |
| Locus | Not Available |
| SNPs | DHPS |
| Gene Sequence |
>1110 bp ATGGAGGGTCCCCAGGAGAGGGAGGTGCCGGCGCCGGCACTGGCCGCCGTGCTGAAGCAC AGTTCGGCACTGCCGTTCGAGACCGCGCAGGTGCGGGGCTACGACTTCAACCGTGGCGTG GACTATCGCGCACTGCTAGAGGCTTTCAGCACCACTGGTTTCCAAGCCACCAACTTCGGG CGCGCGGTACAGCAAGTCAACGCCATGATAGAGAAGAAACTCGAGCCGCTATCCGAGGAT GAAGACCAACATGCAGACTTGACCCAGAGCCGACGCCCACTCACCGGCTGCACCATTTTT CTGGGCTACACATCCAACCTCATCAGTTCAGGCATCCGTGAGACTATCCGTTACCTCGTG CAGCACAACATGGTGGACGTCTTGGTGACCACAGCTGGGGGTGTGGAGGAGGATTTCATC AAGTGCTTGGCGCCCACATACCTGGGCGAGTTCAGCCTCAGGGGGAAGGAGCTACGTGAG AACGGGATCAACAGGATTGGAAACTTGCTGGTGCCCAATGACAATTACTGCAAGTTTGAG GACTGGTTGATGCCCATTCTGGACCAGATGGTGCTGGAGCAGAACACAGAGGGTGTGAAG TGGACACCTTCCAAGATGATCGCCCGGCTTGGCAAGGAGATAAACAACCCAGAGTCCGTG TATTACTGGGCCCAGAAGAACCATATTCCTGTGTTGAGCCCGGCACTCACAGATGGCTCG CTGGGTGACATGATCTTCTTCCACTCCTATAAGAACCCAGGTCTGGTCCTGGACATTGTT GAGGACCTCAAGCTCATCAACACACAGGCCATCTTCGCCAAGCGTACGGGGATGATCATC CTGGGTGGTGGCATGGTCAAGCACCACATCGCCAATGCCAACCTCATGCGGAATGGCGCT GACTATGCCGTCTACATCAACACTGCCCAGGAGTTTGATGGCTCTGACTCAGGCGCCCGG CCAGATGAAGCTGTCTCATGGGGCAAGATCCGGATGGATGCACAGCCTGTCAAGGTCTAT GCTGATGCCTCCTTGGTCTTCCCGCTGCTTGTGGCTGAAACCTTTGCCCAGAAGGTAGAT GCCTTCACGCCCGAGAAGAATGAGGACTGA |
| Protein Properties | |
| Number of Residues | 369 |
| Molecular Weight | 41029.0 |
| Theoretical pI | 4.85 |
| Pfam Domain Function | Not Available |
| Signals |
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| Transmembrane Regions |
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| Protein Sequence |
>Deoxyhypusine synthase MEGPQEREVPAAALAAVLKHSSALPFETAQVRGYDFNRGVDYRALLEAFSTTGFQATNFG RAVQQVNAMIEKKLEPLSEDEDQHADLTQSRRPLTGCTIFLGYTSNLISSGIRETIRYLV QHNMVDVLVTTAGGVEEDFIKCLAPTYLGEFSLRGKELRENGINRIGNLLVPNDNYCKFE DWLMPILDQMVLEQNTEGVKWTPSKMIARLGKEINNPESVYYWAQKNHIPVLSPALTDGS LGDMIFFHSYKNPGLVLDIVEDLKLINTQAIFAKRTGMIILGGGMVKHHIANANLMRNGA DYAVYINTAQEFDGSDSGARPDEAVSWGKIRMDAQPVKVYADASLVFPLLVAETFAQKVD AFMPEKNED |
| External Links | |
| GenBank ID Protein | CAE12195.1 |
| UniProtKB/Swiss-Prot ID | Q6EWQ6 |
| UniProtKB/Swiss-Prot Entry Name | DHYS_BOVIN |
| PDB IDs | |
| GenBank Gene ID | AJ577610 |
| GeneCard ID | DHPS |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |