Identification
BMDB Protein ID BMDBP00129
Secondary Accession Numbers None
Name Acid ceramidase
Synonyms Not Available
Gene Name ASAH1
Protein Type Enzyme
Biological Properties
General Function Involved in ceramidase activity
Specific Function Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine (By similarity). For the reverse synthetic reaction, the natural sphingosine D-erythro isomer is more efficiently utilized as a substrate compared to D-erythro-dihydrosphingosine and D-erythro-phytosphingosine, while the fatty acids with chain lengths of 12 or 14 carbons are the most efficiently used (By similarity). Has also an N-acylethanolamine hydrolase activity (By similarity). By regulating the levels of ceramides, sphingosine and sphingosine-1-phosphate in the epidermis, mediates the calcium-induced differentiation of epidermal keratinocytes (By similarity). Also indirectly regulates tumor necrosis factor/TNF-induced apoptosis (By similarity). By regulating the intracellular balance between ceramides and sphingosine, in adrenocortical cells, probably also acts as a regulator of steroidogenesis (By similarity).
Pathways Not Available
Reactions Not Available
GO Classification Not Available
Cellular Location Not Available
Gene Properties
Chromosome Location 27
Locus Not Available
SNPs ASAH1
Gene Sequence
>1188 bp
ATGTTAGGCTGGAGTCGTCTAACCTTCATCTTGCTGAGCGGGATCGTCACCTGCTTGGTG
GCGCAGCAGGTGCCACCGTGGACTGAAGACTGCAGAAAATCAACCTATCCTCCTTCAGGG
CCCACTTACAGGGGTCCAGTTCCATGGTACACCATAAATCTCGATTTACCACCGTACAAA
AGATGGCATGAATTGATGGTGGTCAAAGCACCAGCGCTGAAAGTTATAGTGAATTCCATG
AAGAATATAGTAAATGCATTTGTGCCAAGTGGAAAAATTATACACTTAGTGGATCAAAAG
TTGCCTGGTCTGCTTGGCAACTTCCCTGGCCCTTTCGAGGAGGAAATGAAGGGGATTGCA
GCTGTAACTGAAATCCCTTTAGGAGAGATTATTTTATTCAATATTTTCTATGAATTTTTT
ACCATTTGTACTTCAATAATAACAGAAGACAAAGAAGGTCATCTACTACATGGGCGAAAC
TTGGATTTTGGAGTATTTCTTGGGTGGAATATAAATAATGATACTTGGGTCATAACTGAG
GAACTAAAACCTTTAACAGTGAATTTGGACTTCCAGAGGAACAATAAAACTCTCTTCAAG
GCAACAACCTTTGCTGGCTACGTGGGCATGTTAACAGGATTCAAACCAGGACTGTTTAGT
GTTACGCTCAATGAACGCTTCAGTATAGATGGTGGTTTTATGGGTGTCATGGAATGGATT
TTGGGAAAGAAAGATGCCCAGTGGGTAGGGTTTATCATTAGATCAGTTCTAGAAAATAGC
ACAAGTTATGAAGAAACCAAGAATATATTGACCAAAACCAAGATATTGGCCCCAGCATAC
TTTATCCTGGGAGGCAACCAGTCTGGGGAGGGTTGTGTGATTACACGAGACAGAAAACAG
TCTCTGGATATATATGAACTCGACCCCAAGCACGGTAGATGGTATGTGGTACAAACAAAT
TATGACCGATGGAAAAATCCCTTCTTCCTTGATGATCGCAGAACACCTGCGAAGATGTGT
CTGAACCAGACAACCCAAGAGAATATCTCATTTGCAACCATATATGATGTCTTGTCAACA
AAACCTATCCTCAACAAGCTGACGGTGTACACAGTCTTGATAGATGTTACCAAAGGTCAA
TTTGAGACGTACCTGCGGGACTGCCCAGACCCCTGCATAGGGTGGTGA
Protein Properties
Number of Residues 395
Molecular Weight 44965.0
Theoretical pI 7.38
Pfam Domain Function Not Available
Signals
  • 1-20
Transmembrane Regions Not Available
Protein Sequence
>Acid ceramidase
MLGWSRLTFILLSGIVTCLVAQQVPPWTEDCRKSTYPPSGPTYRGPVPWYTINLDLPPYK
RWHELMVVKAPALKVIVNSMKNIVNAFVPSGKIIHLVDQKLPGLLGNFPGPFEEEMKGIA
AVTEIPLGEIILFNIFYEFFTICTSIITEDKEGHLLHGRNLDFGVFLGWNINNDTWVITE
ELKPLTVNLDFQRNNKTLFKATTFAGYVGMLTGFKPGLFSVTLNERFSIDGGFMGVMEWI
LGKKDAQWVGFIIRSVLENSTSYEETKNILTKTKILAPAYFILGGNQSGEGCVITRDRKQ
SLDIYELDPKHGRWYVVQTNYDRWKNPFFLDDRRTPAKMCLNQTTQENISFATIYDVLST
KPILNKLTVYTVLIDVTKGQFETYLRDCPDPCIGW
GenBank ID Protein AAI18456.3
UniProtKB/Swiss-Prot ID Q17QB3
UniProtKB/Swiss-Prot Entry Name ASAH1_BOVIN
PDB IDs Not Available
GenBank Gene ID BC118455
GeneCard ID ASAH1
GenAtlas ID Not Available
HGNC ID Not Available
References
General References Not Available