Showing Protein ADP-ribose glycohydrolase ARH3 (BMDBP00132)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00132 |
| Secondary Accession Numbers | None |
| Name | ADP-ribose glycohydrolase ARH3 |
| Synonyms | Not Available |
| Gene Name | ADPRS |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Posttranslational modification, protein turnover, chaperones |
| Specific Function | ADP-ribose glycohydrolase that preferentially hydrolyzes the scissile alpha-O-linkage attached to the anomeric C1'' position of ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on serine, free poly(ADP-ribose) and O-acetyl-ADP-D-ribose. Specifically acts as a serine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to serine residues on proteins, thereby playing a key role in DNA damage response. Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Does not hydrolyze ADP-ribosyl-arginine, -cysteine, -diphthamide, or -asparagine bonds. Also able to degrade protein free poly(ADP-ribose), which is synthesized in response to DNA damage: free poly(ADP-ribose) acts as a potent cell death signal and its degradation by ADPRHL2 protects cells from poly(ADP-ribose)-dependent cell death, a process named parthanatos. Also hydrolyzes free poly(ADP-ribose) in mitochondria. Specifically digests O-acetyl-ADP-D-ribose, a product of deacetylation reactions catalyzed by sirtuins. Specifically degrades 1''-O-acetyl-ADP-D-ribose isomer, rather than 2''-O-acetyl-ADP-D-ribose or 3''-O-acetyl-ADP-D-ribose isomers. |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 3 |
| Locus | Not Available |
| SNPs | ADPRS |
| Gene Sequence |
>1098 bp ATGGCGGCGGCGGCAGCGATGACGGCGGCGGGCTGCGGAGGGGCTGGGGCGGCACGCTCC CTCTCCCGCTTCCGAGGCTGCCTGGCAGGCGCGCTGCTCGGGGACTGCGTGGGCGCCGTC TACGAGGCGCGCGACACCGTCGACCTGACGTCAGTCCTGCGTCAGGTCCAGGATTTGGAG CCGGACCCCGGCTCTCCCGGGAGCGCGCGGACAGAAGCACTGTGCTACACGGACGACACA GCCATGGCCAGGGCGCTGGTGCAGTCCCTGCTGGCCAAGGAGGCCTTCGACGAGGTGGAC ATGGCTCACAGGTTTGCTCAGGAGTACAAGAAGGACCCTGACCGGGGTTACGGTGCTGGA GTGATCACCGTCTTCAGGAAACACCTAAGCCCCAGATGCCGGGATGTCTTTGAGCCTGCA CGCGCCCAGTTCAATGGCAAAGGCTCCTACGGCAACGGGGGTGCCATGCGGGTGGCCGGC ATCTCCCTGGCCTATAGCAGCGTGCAGGATGTGCAGAAGTTCGCCCGGCTCTCGGCCCAG CTGACACACGCCTCCTCCCTGGGTTACAATGGTGCCATCCTGCAGGCCCTGGCTGTGCAC CTGGCCTTGCAGGGCGAGTCGTCCAGTGAGCACTTCCTCGAGCAGCTCCTTGGCCACATG GAAGAGCTGGAGAGTGATGCCCAGTCCGTGCTGGATGCCAGGGAGTTGGGCATGGAGGAG CGTCCGTACTCCAGCCGACTGAAGAAGATCGGGGAGCTTCTAGAGCAGGACTCAGTGACC AGAGAGGAGGTGGTGTCCGAGCTAGGAAATGGCATTGCTGCCTTTGAATCTGTGCCCACC GCCATCTATTGCTTCCTGCGCTGCATGGAGCCCGACCCCGAGATCCCCTCTACCTTCAAC AGCCTCCAAAGGACTCTCGTCTATTCCATCTCGCTCGGTGGGGACACGGACACCATTGCC ACCATGGCCGGGGCCATTGCTGGCGCCTACTATGGGATGGAACAGGTGCCAGAGAGCTGG CAGCAAAGCTGTGAAGGCTATGAGGAGACTGACGTCCTGGCCCAGAGCCTGCACCGGGTC TTCCAGAAGAGTCTTTGA |
| Protein Properties | |
| Number of Residues | 365 |
| Molecular Weight | 39221.0 |
| Theoretical pI | 4.56 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>Poly(ADP-ribose) glycohydrolase ARH3 MAAAAAMTAAGCGGAGAARSLSRFRGCLAGALLGDCVGAVYEARDTVDLTSVLRQVQDLE PDPGSPGSARTEALCYTDDTAMARALVQSLLAKEAFDEVDMAHRFAQEYKKDPDRGYGAG VITVFRKHLSPRCRDVFEPARAQFNGKGSYGNGGAMRVAGISLAYSSVQDVQKFARLSAQ LTHASSLGYNGAILQALAVHLALQGESSSEHFLEQLLGHMEELESDAQSVLDARELGMEE RPYSSRLKKIGELLEQDSVTREEVVSELGNGIAAFESVPTAIYCFLRCMEPDPEIPSTFN SLQRTLVYSISLGGDTDTIATMAGAIAGAYYGMEQVPESWQQSCEGYEETDVLAQSLHRV FQKSL |
| External Links | |
| GenBank ID Protein | AAI03361.1 |
| UniProtKB/Swiss-Prot ID | Q3SYV9 |
| UniProtKB/Swiss-Prot Entry Name | ADPRS_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | BC103360 |
| GeneCard ID | ADPRS |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |