Showing Protein Poly(ADP-ribose) glycohydrolase (BMDBP00135)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00135 |
| Secondary Accession Numbers | None |
| Name | Poly(ADP-ribose) glycohydrolase |
| Synonyms | Not Available |
| Gene Name | PARG |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in poly(ADP-ribose) glycohydrolase activity |
| Specific Function | Poly(ADP-ribose) glycohydrolase that degrades poly(ADP-ribose) by hydrolyzing the ribose-ribose bonds present in poly(ADP-ribose) (PubMed:15658938). PARG acts both as an endo- and exoglycosidase, releasing poly(ADP-ribose) of different length as well as ADP-ribose monomers. It is however unable to cleave the ester bond between the terminal ADP-ribose and ADP-ribosylated residues, leaving proteins that are mono-ADP-ribosylated. Poly(ADP-ribose) is synthesized after DNA damage is only present transiently and is rapidly degraded by PARG. Required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress, while it is not required for recovery from transient replicative stress. Required for retinoid acid-dependent gene transactivation, probably by removing poly(ADP-ribose) from histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters. Involved in the synthesis of ATP in the nucleus, together with PARP1, NMNAT1 and NUDT5. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (By similarity). |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 28 |
| Locus | Not Available |
| SNPs | PARG |
| Gene Sequence |
>2934 bp ATGAGTGCGGGCCCCGGCTGTGAGCCCTGCACCAAGCGACCCCGCTGGGACGCCGCTGCA ACTTCTCCGCCGGCCGCCTCGGACGCCCGGAGCTTCCCCGGCAGGCAGAGGCGCGTCCTC GATTCCAAGGACGCTCCGGTGCAGTTCAGGGTCCCGCCGTCCTCGTCAGGCTGCGCCCTG GGCCGGGCGGGACAGCACCGAGGCAGCGCCACCTCTCTTGTTTTCAAACAGAAGACTATA ACCAGTTGGATGGACACTAAAGGAATCAAGACAGTTGAATCAGAAAGTTTGCATAGTAAA GAAAACAACAATACAAGAGAAGAATCCATGATGAGTTCTGTACAAAAAGATAACTTTTAT CAACATAACATGGAAAAATTAGAAAATGTTTCTCAGCTAGGTTTTGATAAGTCACCAGTT GAAAAAGGTACACAGTATTTGAAGCAGCATCAGACTGCGGCTATGTGTAAGTGGCAGAAT GAAGGGCCACACTCAGAACGGCTTTTGGAAAGTGAACCTCCAGCGGTAACTCTGGTACCA GAGCAGTTCAGTAATGCTAATGTCGATCAGTCGTCCCCAAAGGATGATCACAGTGACACA AATAGTGAGGAGAGTAGAGATAATCAGCAGTTTTTGACACATGTAAAGCTTGCGAATGCA AAGCAGACGATGGAAGATGAACAGGGCAGAGAAGCCAGAAGCCACCAGAAGTGTGGCAAG GCTTGCCATCCTGCAGAAGCCTGTGCAGGGTGTCAGCAGGAGGAGACAGACGTGGTGTCC GAGAGCCCCTTGTCGGACACTGGCTCTGAGGATGTTGGTACTGGACTGAAAAATGCCAAC AGATTGAATAGACAAGAAAGTAGTCTAGGAAATTCTCCTCCATTTGAGAAAGAAAGTGAA CCTGAGTCACCAATGGATGTAGATAATTCCAAAAATAGTTGTCAGGATTCAGAAGCAGAT GAAGAGACAAGTCCAGGTTTTGATGAACAGGAAGATAGCAGTTCTGCTCAAACAGCAAAT AAACCTTCAAGGTTCCAACCAAGAGAAGCTGACACTGAGTTGAGGAAGCGGTCCTCTGCT AAGGGAGGTGAGATTCGATTACATTTCCAATTTGAAGGAGGAGAGAGTCGAGCTGGAATG AATGATGTGAATGCCAAACGACCTGGAAGTACTTCTAGCCTGAATGTAGAGTGCAGAAAT TCTAAGCAACATGGGAGAAAGGATTCTAAAATCACAGATCATTTCATGAGAGTGCCCAAA GCAGAGGACAAAAGAAAAGAACAATGTGAAATGAAACATCAAAGAACAGAAAGGAAGATC CCTAAATACATTCCACCTCACCTTTCTCCAGATAAGAAATGGCTTGGAACTCCTATTGAG GAGATGAGGAGAATGCCAAGGTGTGGGATCCGGCTGCCTCCCTTGAGACCATCTGCCAAT CACACAGTGACTATTCGGGTAGATCTTTTGCGAATAGGAGAAGTTCCTAAACCTTTCCCA ACACATTTTAAAGATTTGTGGGACAACAAGCATGTTAAGATGCCTTGTTCAGAACAAAAC TTGTACCCTGTGGAAGATGAGAATGGTGAGCGAGCTGCAGGCAGCCGGTGGGAACTCATT CAGACTGCACTTCTCAACAGGCTCACTCGGCCCCAGAACCTGAAGGATGCTATTCTGAAG TACAATGTGGCATATTCTAAGAAATGGGACTTTACAGCTTTGATTGATTTCTGGGATAAG GTACTAGAAGAAGCAGAAGCTCAACACTTGTATCAGTCCATCTTGCCTGATATGGTGAAA ATTGCACTCTGTCTGCCAAATATTTGTACCCAGCCAATACCACTCCTGAAACAGAAGATG AATCATTCCATCACAATGTCACAGGAACAGATTGCCAGTCTTTTAGCTAATGCTTTCTTC TGCACGTTTCCACGACGCAATGCCAAGATGAAATCAGAGTATTCCAGTTATCCAGATATT AACTTCAATCGGTTGTTTGAAGGACGTTCATCAAGGAAACCAGAGAAGCTTAAAACGCTC TTCTGCTACTTTAGAAGAGTCACAGAGAAAAAACCCACTGGGTTGGTGACATTCACAAGA CAGAGTCTTGAAGATTTTCCAGAGTGGGAAAGATGTGAAAAACTCCTGACTCGACTGCAT GTCACTTACGAAGGTACCATAGAAGGAAACGGCCAGGGCATGCTACAGGTGGATTTTGCA AACCGTTTCGTTGGAGGTGGTGTAACCAGTGCAGGACTTGTGCAAGAAGAAATCCGCTTT TTAATCAACCCTGAGTTGATTGTTTCACGGCTCTTCACTGAGGTGCTGGATCACAATGAA TGTCTTATCATCACAGGTACTGAGCAGTACAGTGAATACACAGGCTATGCCGAAACATAC CGCTGGGCCCGGAGCCATGAAGACAGGAGCGAAAGGGACGACTGGCAGAGGCGCACGACT GAGATCGTCGCCATCGACGCCCTCCACTTCAGACGCTACCTCGACCAGTTTGTGCCCGAG AAGATCAGACGGGAGCTTAACAAGGCTTACTGTGGATTTCTTCGTCCTGGAGTTTCTTCA GAGAACCTGTCTGCAGTGGCTACAGGAAACTGGGGCTGTGGTGCCTTTGGGGGTGATGCT AGACTAAAAGCCTTAATACAGATCCTGGCAGCTGCTGTAGCTGAGCGAGACGTGGTTTAT TTCACCTTTGGGGACTCAGAACTGATGAGAGACATTTACAGCATGCATACATTCCTCACT GAGAGGAAACTGACTGTTGGAGAAGTATATAAGCTGCTGCTACGATATTACAATGAAGAA TGCAGAAACTGCTCCACCCCCGGACCAGACATCAAGCTTTATCCATTCATATACCATGCA GTTGAGTCCTGTACACAGACCACCAACCAGCCGGGACAAAGGACGGGGGCCTGA |
| Protein Properties | |
| Number of Residues | 977 |
| Molecular Weight | 110837.0 |
| Theoretical pI | 7.03 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>Poly(ADP-ribose) glycohydrolase MSAGPGCEPCTKRPRWDAAATSPPAASDARSFPGRQRRVLDSKDAPVQFRVPPSSSGCAL GRAGQHRGSATSLVFKQKTITSWMDTKGIKTVESESLHSKENNNTREESMMSSVQKDNFY QHNMEKLENVSQLGFDKSPVEKGTQYLKQHQTAAMCKWQNEGPHSERLLESEPPAVTLVP EQFSNANVDQSSPKDDHSDTNSEESRDNQQFLTHVKLANAKQTMEDEQGREARSHQKCGK ACHPAEACAGCQQEETDVVSESPLSDTGSEDVGTGLKNANRLNRQESSLGNSPPFEKESE PESPMDVDNSKNSCQDSEADEETSPGFDEQEDSSSAQTANKPSRFQPREADTELRKRSSA KGGEIRLHFQFEGGESRAGMNDVNAKRPGSTSSLNVECRNSKQHGRKDSKITDHFMRVPK AEDKRKEQCEMKHQRTERKIPKYIPPHLSPDKKWLGTPIEEMRRMPRCGIRLPPLRPSAN HTVTIRVDLLRIGEVPKPFPTHFKDLWDNKHVKMPCSEQNLYPVEDENGERAAGSRWELI QTALLNRLTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVK IALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDI NFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKLLTRLH VTYEGTIEGNGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIVSRLFTEVLDHNE CLIITGTEQYSEYTGYAETYRWARSHEDRSERDDWQRRTTEIVAIDALHFRRYLDQFVPE KIRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAVAERDVVY FTFGDSELMRDIYSMHTFLTERKLTVGEVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHA VESCTQTTNQPGQRTGA |
| External Links | |
| GenBank ID Protein | AAB53370.1 |
| UniProtKB/Swiss-Prot ID | O02776 |
| UniProtKB/Swiss-Prot Entry Name | PARG_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | U78975 |
| GeneCard ID | PARG |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |