| Identification |
|---|
| BMDB Protein ID
| BMDBP00135 |
| Secondary Accession Numbers
| None |
| Name
| Poly(ADP-ribose) glycohydrolase |
| Synonyms
|
Not Available
|
| Gene Name
| PARG |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in poly(ADP-ribose) glycohydrolase activity |
| Specific Function
| Poly(ADP-ribose) glycohydrolase that degrades poly(ADP-ribose) by hydrolyzing the ribose-ribose bonds present in poly(ADP-ribose) (PubMed:15658938). PARG acts both as an endo- and exoglycosidase, releasing poly(ADP-ribose) of different length as well as ADP-ribose monomers. It is however unable to cleave the ester bond between the terminal ADP-ribose and ADP-ribosylated residues, leaving proteins that are mono-ADP-ribosylated. Poly(ADP-ribose) is synthesized after DNA damage is only present transiently and is rapidly degraded by PARG. Required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress, while it is not required for recovery from transient replicative stress. Required for retinoid acid-dependent gene transactivation, probably by removing poly(ADP-ribose) from histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters. Involved in the synthesis of ATP in the nucleus, together with PARP1, NMNAT1 and NUDT5. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 28 |
| Locus
| Not Available |
| SNPs
| PARG |
| Gene Sequence
|
>2934 bp
ATGAGTGCGGGCCCCGGCTGTGAGCCCTGCACCAAGCGACCCCGCTGGGACGCCGCTGCA
ACTTCTCCGCCGGCCGCCTCGGACGCCCGGAGCTTCCCCGGCAGGCAGAGGCGCGTCCTC
GATTCCAAGGACGCTCCGGTGCAGTTCAGGGTCCCGCCGTCCTCGTCAGGCTGCGCCCTG
GGCCGGGCGGGACAGCACCGAGGCAGCGCCACCTCTCTTGTTTTCAAACAGAAGACTATA
ACCAGTTGGATGGACACTAAAGGAATCAAGACAGTTGAATCAGAAAGTTTGCATAGTAAA
GAAAACAACAATACAAGAGAAGAATCCATGATGAGTTCTGTACAAAAAGATAACTTTTAT
CAACATAACATGGAAAAATTAGAAAATGTTTCTCAGCTAGGTTTTGATAAGTCACCAGTT
GAAAAAGGTACACAGTATTTGAAGCAGCATCAGACTGCGGCTATGTGTAAGTGGCAGAAT
GAAGGGCCACACTCAGAACGGCTTTTGGAAAGTGAACCTCCAGCGGTAACTCTGGTACCA
GAGCAGTTCAGTAATGCTAATGTCGATCAGTCGTCCCCAAAGGATGATCACAGTGACACA
AATAGTGAGGAGAGTAGAGATAATCAGCAGTTTTTGACACATGTAAAGCTTGCGAATGCA
AAGCAGACGATGGAAGATGAACAGGGCAGAGAAGCCAGAAGCCACCAGAAGTGTGGCAAG
GCTTGCCATCCTGCAGAAGCCTGTGCAGGGTGTCAGCAGGAGGAGACAGACGTGGTGTCC
GAGAGCCCCTTGTCGGACACTGGCTCTGAGGATGTTGGTACTGGACTGAAAAATGCCAAC
AGATTGAATAGACAAGAAAGTAGTCTAGGAAATTCTCCTCCATTTGAGAAAGAAAGTGAA
CCTGAGTCACCAATGGATGTAGATAATTCCAAAAATAGTTGTCAGGATTCAGAAGCAGAT
GAAGAGACAAGTCCAGGTTTTGATGAACAGGAAGATAGCAGTTCTGCTCAAACAGCAAAT
AAACCTTCAAGGTTCCAACCAAGAGAAGCTGACACTGAGTTGAGGAAGCGGTCCTCTGCT
AAGGGAGGTGAGATTCGATTACATTTCCAATTTGAAGGAGGAGAGAGTCGAGCTGGAATG
AATGATGTGAATGCCAAACGACCTGGAAGTACTTCTAGCCTGAATGTAGAGTGCAGAAAT
TCTAAGCAACATGGGAGAAAGGATTCTAAAATCACAGATCATTTCATGAGAGTGCCCAAA
GCAGAGGACAAAAGAAAAGAACAATGTGAAATGAAACATCAAAGAACAGAAAGGAAGATC
CCTAAATACATTCCACCTCACCTTTCTCCAGATAAGAAATGGCTTGGAACTCCTATTGAG
GAGATGAGGAGAATGCCAAGGTGTGGGATCCGGCTGCCTCCCTTGAGACCATCTGCCAAT
CACACAGTGACTATTCGGGTAGATCTTTTGCGAATAGGAGAAGTTCCTAAACCTTTCCCA
ACACATTTTAAAGATTTGTGGGACAACAAGCATGTTAAGATGCCTTGTTCAGAACAAAAC
TTGTACCCTGTGGAAGATGAGAATGGTGAGCGAGCTGCAGGCAGCCGGTGGGAACTCATT
CAGACTGCACTTCTCAACAGGCTCACTCGGCCCCAGAACCTGAAGGATGCTATTCTGAAG
TACAATGTGGCATATTCTAAGAAATGGGACTTTACAGCTTTGATTGATTTCTGGGATAAG
GTACTAGAAGAAGCAGAAGCTCAACACTTGTATCAGTCCATCTTGCCTGATATGGTGAAA
ATTGCACTCTGTCTGCCAAATATTTGTACCCAGCCAATACCACTCCTGAAACAGAAGATG
AATCATTCCATCACAATGTCACAGGAACAGATTGCCAGTCTTTTAGCTAATGCTTTCTTC
TGCACGTTTCCACGACGCAATGCCAAGATGAAATCAGAGTATTCCAGTTATCCAGATATT
AACTTCAATCGGTTGTTTGAAGGACGTTCATCAAGGAAACCAGAGAAGCTTAAAACGCTC
TTCTGCTACTTTAGAAGAGTCACAGAGAAAAAACCCACTGGGTTGGTGACATTCACAAGA
CAGAGTCTTGAAGATTTTCCAGAGTGGGAAAGATGTGAAAAACTCCTGACTCGACTGCAT
GTCACTTACGAAGGTACCATAGAAGGAAACGGCCAGGGCATGCTACAGGTGGATTTTGCA
AACCGTTTCGTTGGAGGTGGTGTAACCAGTGCAGGACTTGTGCAAGAAGAAATCCGCTTT
TTAATCAACCCTGAGTTGATTGTTTCACGGCTCTTCACTGAGGTGCTGGATCACAATGAA
TGTCTTATCATCACAGGTACTGAGCAGTACAGTGAATACACAGGCTATGCCGAAACATAC
CGCTGGGCCCGGAGCCATGAAGACAGGAGCGAAAGGGACGACTGGCAGAGGCGCACGACT
GAGATCGTCGCCATCGACGCCCTCCACTTCAGACGCTACCTCGACCAGTTTGTGCCCGAG
AAGATCAGACGGGAGCTTAACAAGGCTTACTGTGGATTTCTTCGTCCTGGAGTTTCTTCA
GAGAACCTGTCTGCAGTGGCTACAGGAAACTGGGGCTGTGGTGCCTTTGGGGGTGATGCT
AGACTAAAAGCCTTAATACAGATCCTGGCAGCTGCTGTAGCTGAGCGAGACGTGGTTTAT
TTCACCTTTGGGGACTCAGAACTGATGAGAGACATTTACAGCATGCATACATTCCTCACT
GAGAGGAAACTGACTGTTGGAGAAGTATATAAGCTGCTGCTACGATATTACAATGAAGAA
TGCAGAAACTGCTCCACCCCCGGACCAGACATCAAGCTTTATCCATTCATATACCATGCA
GTTGAGTCCTGTACACAGACCACCAACCAGCCGGGACAAAGGACGGGGGCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 977 |
| Molecular Weight
| 110837.0 |
| Theoretical pI
| 7.03 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Poly(ADP-ribose) glycohydrolase
MSAGPGCEPCTKRPRWDAAATSPPAASDARSFPGRQRRVLDSKDAPVQFRVPPSSSGCAL
GRAGQHRGSATSLVFKQKTITSWMDTKGIKTVESESLHSKENNNTREESMMSSVQKDNFY
QHNMEKLENVSQLGFDKSPVEKGTQYLKQHQTAAMCKWQNEGPHSERLLESEPPAVTLVP
EQFSNANVDQSSPKDDHSDTNSEESRDNQQFLTHVKLANAKQTMEDEQGREARSHQKCGK
ACHPAEACAGCQQEETDVVSESPLSDTGSEDVGTGLKNANRLNRQESSLGNSPPFEKESE
PESPMDVDNSKNSCQDSEADEETSPGFDEQEDSSSAQTANKPSRFQPREADTELRKRSSA
KGGEIRLHFQFEGGESRAGMNDVNAKRPGSTSSLNVECRNSKQHGRKDSKITDHFMRVPK
AEDKRKEQCEMKHQRTERKIPKYIPPHLSPDKKWLGTPIEEMRRMPRCGIRLPPLRPSAN
HTVTIRVDLLRIGEVPKPFPTHFKDLWDNKHVKMPCSEQNLYPVEDENGERAAGSRWELI
QTALLNRLTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVK
IALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDI
NFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKLLTRLH
VTYEGTIEGNGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIVSRLFTEVLDHNE
CLIITGTEQYSEYTGYAETYRWARSHEDRSERDDWQRRTTEIVAIDALHFRRYLDQFVPE
KIRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAVAERDVVY
FTFGDSELMRDIYSMHTFLTERKLTVGEVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHA
VESCTQTTNQPGQRTGA
|
| External Links |
|---|
| GenBank ID Protein
| AAB53370.1 |
| UniProtKB/Swiss-Prot ID
| O02776 |
| UniProtKB/Swiss-Prot Entry Name
| PARG_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| U78975 |
| GeneCard ID
| PARG |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
