| Identification |
|---|
| BMDB Protein ID
| BMDBP00141 |
| Secondary Accession Numbers
| None |
| Name
| Tyrosine-protein kinase Fyn |
| Synonyms
|
Not Available
|
| Gene Name
| FYN |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ATP binding |
| Specific Function
| Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Phosphorylates PTK2B/PYK2 in response to T-cell receptor activation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1. In mast cells, phosphorylates CLNK after activation of immunoglobulin epsilon receptor signaling (By similarity). |
| Pathways
|
- BCR Signaling Pathway
- Fc Epsilon Receptor I Signaling in Mast Cells
- GnRH Signaling Pathway
- T Cell Receptor Signaling Pathway
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 9 |
| Locus
| Not Available |
| SNPs
| FYN |
| Gene Sequence
|
>1614 bp
ATGGGCTGTGTGCAATGTAAGGACAAAGAAGCAACAAAACTGACGGAGGAGAGGGATGGC
AGTCTGAACCAGAGCTCCGGGTACCGCTATGGTACAGACCCCACTCCTCAGCACTACCCC
AGCTTCGGTGTGACCTCCATCCCGAACTACAACAACTTCCACGGGGCCGGGGGCCAAGGA
CTCACCGTCTTTGGGGGTGTGAACTCTTCGTCTCATACTGGGACCTTGCGAACAAGAGGA
GGAACAGGAGTGACCCTGTTTGTGGCCCTTTATGACTATGAAGCACGGACGGAAGATGAC
CTGAGTTTTCACAAAGGAGAAAAATTTCAAATATTGAACAGCTCGGAAGGAGATTGGTGG
GAAGCACGCTCCTTGACAACTGGAGAGACGGGTTACATTCCCAGCAATTATGTGGCTCCA
GTTGACTCCATCCAGGCAGAAGAGTGGTACTTTGGAAAACTCGGCCGGAAAGATGCTGAG
CGACAGCTTTTGTCCTTTGGAAACCCACGGGGTACCTTTCTTATCCGTGAGAGTGAAACC
ACCAAAGGTGCCTATTCACTTTCTATCCGAGACTGGGATGATATGAAAGGAGACCATGTC
AAACATTATAAAATTCGCAAACTTGACAACGGTGGATACTATATTACCACCCGGGCCCAA
TTTGAAACCCTTCAGCAGCTTGTACAACATTACTCAGAGAGAGCTGCAGGCCTCTGCTGC
CGCCTAGTAGTTCCCTGTCACAAAGGGATGCCACGGCTTACCGATCTGTCTGTCAAAACC
AAAGATGTCTGGGAAATCCCTCGAGAATCCCTGCAGTTGATCAAGAGACTGGGAAATGGG
CAGTTTGGGGAAGTATGGATGGGTACCTGGAATGGAAACACAAAAGTAGCCATAAAGACT
CTTAAACCAGGCACAATGTCCCCTGAATCATTCCTTGAGGAGGCGCAGATCATGAAGAAG
TTGAAGCACGACAAACTGGTCCAGCTATATGCCGTGGTGTCCGAGGAGCCCATCTACATC
GTCACCGAGTATATGAATAAAGGAAGTTTACTCGATTTCTTGAAAGATGGGGAAGGAAGG
GCTCTGAAATTACCAAATCTCGTGGACATGGCAGCACAGGTTGCCGCGGGAATGGCGTAC
ATCGAGCGCATGAATTACATCCACAGAGACCTGCGGTCAGCAAACATTCTCGTGGGGAAT
GGACTAATTTGCAAGATCGCCGACTTCGGATTGGCCAGGTTGATCGAGGACAATGAGTAC
ACAGCAAGACAAGGCGCCAAGTTCCCCATCAAGTGGACGGCCCCCGAAGCAGCCCTGTAC
GGGAGGTTCACAATCAAGTCTGACGTGTGGTCTTTTGGAATCTTACTCACAGAGCTGGTC
ACCAAAGGAAGAGTTCCGTACCCAGGCATGAACAACCGGGAGGTGCTGGAGCAGGTGGAG
CGCGGTTACAGGATGCCCTGTCCACAGGACTGCCCCATCTCCCTCCACGAGCTCATGATA
CACTGCTGGAAAAAGGACCCCGAAGAGCGGCCCACTTTCGAGTACCTGCAGGGCTTCCTG
GAAGACTACTTCACCGCAACAGAGCCTCAGTATCAACCCGGGGAAAACCTGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 537 |
| Molecular Weight
| 60718.0 |
| Theoretical pI
| 6.65 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 78-98
- 123-146
- 196-216
- 223-243
- 299-319
- 340-358
- 859-879
- 919-939
- 991-1011
- 1014-1034
- 1096-1116
- 1131-1151
|
| Protein Sequence
|
>Proto-oncogene tyrosine-protein kinase Fyn
MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHGAGGQG
LTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWW
EARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESET
TKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCC
RLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKT
LKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGR
ALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEY
TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVE
RGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQGFLEDYFTATEPQYQPGENL
|
| External Links |
|---|
| GenBank ID Protein
| AAI26592.1 |
| UniProtKB/Swiss-Prot ID
| A0JNB0 |
| UniProtKB/Swiss-Prot Entry Name
| FYN_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC126591 |
| GeneCard ID
| FYN |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
