| Identification |
|---|
| BMDB Protein ID
| BMDBP00145 |
| Secondary Accession Numbers
| None |
| Name
| Sodium/potassium-transporting ATPase subunit alpha-1 |
| Synonyms
|
Not Available
|
| Gene Name
| ATP1A1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Inorganic ion transport and metabolism |
| Specific Function
| This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. |
| Pathways
|
- Gastric Acid Production
- Kidney Function
- Lactose Degradation
- Trehalose Degradation
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 3 |
| Locus
| Not Available |
| SNPs
| ATP1A1 |
| Gene Sequence
|
>3066 bp
ATGGGGAAGGGGGTTGGACGTGATAAATATGAACCGGCAGCTGTTTCAGAGCATGGGGAC
AAGAAAAAAGCCAAGAAAGAGAGGGATATGGACGAGCTGAAGAAAGAAGTTTCTATGGAT
GATCATAAACTTAGCCTTGATGAACTTCATCGCAAATATGGAACAGACTTGAGCCGAGGC
TTAACAACTGCTCGAGCTGCCGAGATCCTAGCCAGAGATGGACCCAACGCCCTCACGCCC
CCTCCCACGACCCCTGAATGGGTCAAGTTCTGTCGACAGCTGTTTGGGGGGTTCTCAATG
TTACTGTGGATTGGAGCAGTTCTTTGCTTCCTGGCCTATGGTATCCAAGCTGCTACAGAA
GAGGAACCTCAAAATGATAATCTGTACCTTGGTGTGGTGCTGTCTGCTGTCGTCATCATA
ACCGGGTGTTTCTCCTACTATCAAGAAGCTAAAAGCTCAAAGATCATGGAGTCCTTCAAA
AACATGGTTCCTCAGCAAGCCCTCGTGATTCGAAATGGTGAGAAAATGAGCATAAATGCG
GAAGAGGTTGTCGTCGGAGATCTGGTGGAAGTGAAAGGAGGGGATCGAATTCCTGCCGAT
CTCAGGATCATTTCTGCAAATGGCTGCAAGGTGGATAACTCCTCACTCACGGGAGAATCA
GAGCCACAGACCAGGTCTCCGGATTTCACCAATGAAAATCCCCTGGAGACACGGAACATT
GCCTTTTTTTCAACTAACTGTGTTGAAGGCACTGCACGTGGCATTGTCGTGTATACTGGG
GATCGAACCGTGATGGGCAGAATTGCCACGCTGGCTTCTGGGCTGGAGGGGGGCCAGACT
CCCATCGCTGCGGAAATTGAACATTTTATCCACATCATCACGGGTGTGGCTGTGTTCCTG
GGCGTGTCGTTCTTCATCCTTTCTCTGATCCTTGAGTACACCTGGCTGGAGGCTGTCATC
TTCCTCATCGGCATCATTGTAGCCAACGTGCCAGAGGGTTTGCTGGCCACCGTCACGGTG
TGCCTGACGCTGACTGCAAAGCGCATGGCCAGGAAAAACTGCTTAGTGAAGAACCTGGAG
GCTGTGGAGACCTTGGGATCCACGTCCACCATCTGCTCAGACAAAACTGGAACTCTGACC
CAGAACCGAATGACAGTGGCCCACATGTGGTTCGACAACCAAATCCACGAGGCGGACACG
ACAGAGAATCAGAGCGGTGTTTCATTTGACAAGACTTCGGCCACGTGGCTCGCTCTGTCC
AGAATTGCAGGTCTTTGTAACAGGGCCGTGTTTCAGGCTAACCAGGATAACCTGCCTATC
CTGAAGCGGGCTGTAGCGGGTGATGCCTCAGAGTCTGCGCTCCTGAAGTGCATTGAGGTG
TGCTGCGGTTCTGTGAAGGAGATGAGAGAGAGATACACCAAGATCGTCGAGATCCCATTC
AACTCCACCAACAAGTACCAGTTATCCATCCACAAGAACGCCAATGCAGGTGAGCCCCGG
CACCTACTGGTGATGAAAGGTGCCCCAGAAAGGATCTTGGACCGCTGCAGCTCCATCCTC
ATCCATGGCAAGGAGCAGCCCCTGGACGAGGAGCTGAAGGACGCTTTTCAGAATGCCTAC
CTGGAGCTGGGTGGCCTCGGAGAGCGTGTGCTGGGTTTTTGCCACTTGCTGCTGCCAGAT
GAGCAGTTTCCTGAAGGCTTCCAGTTTGACACCGACGATGTGAACTTCCCTGTTGATAAT
CTCTGCTTCGTGGGACTCATCTCCATGATTGACCCACCACGGGCTGCTGTCCCAGATGCT
GTGGGCAAATGCCGAAGTGCTGGAATCAAGGTCATCATGGTCACCGGAGACCATCCCATC
ACTGCCAAAGCCATTGCCAAAGGTGTGGGGATCATCTCAGAAGGTAATGAGACTGTAGAA
GACATTGCTGCCCGCCTCAACATCCCAGTGAGCCAGGTGAACCCCAGGGATGCCCGGGCC
TGCGTGGTGCATGGAAGTGATCTGAAGGACATGACTCCCGAGCAGCTGGATGACATCTTG
AAGTACCACACAGAGATTGTGTTCGCCAGGACCTCTCCGCAGCAGAAGCTCATCATTGTG
GAAGGCTGCCAGAGACAGGGTGCCATCGTGGCTGTAACTGGAGACGGTGTCAATGACTCC
CCGGCTTTGAAGAAGGCAGACATTGGGGTTGCCATGGGGATTGCAGGCTCAGACGTGTCT
AAGCAAGCTGCTGACATGATTCTCCTAGATGACAACTTTGCCTCAATTGTGACTGGAGTA
GAGGAAGGTCGTCTGATCTTTGATAACTTGAAGAAATCCATTGCTTATACCCTCACCAGT
AACATTCCTGAGATTACCCCCTTCCTGATATTTATTATTGCAAACATTCCACTCCCTCTG
GGGACCGTCACCATCCTCTGCATCGACTTGGGAACGGACATGGTCCCTGCTATCTCCTTG
GCTTATGAGCAGGCTGAGAGCGACATCATGAAGAGGCAGCCCAGAAACCCCCAGACGGAC
AAACTCGTGAACGAGCGGCTGATCAGCATGGCCTATGGACAGATTGGTATGATCCAGGCC
CTGGGGGGCTTCTTCACTTACTTTGTTATCATGGCTGAGAACGGCTTCCTCCCAAATCAC
CTGCTGGGCATCCGAGTGACCTGGGATGACCGTTGGATCAACGATGTGGAGGACAGCTAT
GGGCAGCAGTGGACCTATGAACAGAGGAAGATTGTGGAGTTCACCTGCCACACGGCCTTC
TTTGTCAGTATCGTGGTGGTGCAGTGGGCTGACCTGGTCATCTGCAAGACCAGGAGGAAT
TCTGTCTTCCAGCAGGGGATGAAGAACAAGATCTTAATATTTGGCCTCTTTGAAGAGACA
GCCCTTGCTGCTTTCCTTTCCTACTGCCCTGGAATGGGTGTTGCCCTGAGGATGTATCCC
CTCAAACCTACCTGGTGGTTCTGTGCCTTCCCCTACTCTCTTCTCATCTTCGTGTATGAC
GAAGTCCGGAAGCTCATCATCAGGCGACGTCCTGGCGGTTGGGTGGAGAAGGAGACCTAC
TACTAG
|
| Protein Properties |
|---|
| Number of Residues
| 1021 |
| Molecular Weight
| 112643.0 |
| Theoretical pI
| 5.19 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 86-106
- 130-150
- 287-306
- 319-336
- 771-790
- 801-821
- 842-864
- 917-936
- 950-968
- 984-1004
|
| Protein Sequence
|
>Sodium/potassium-transporting ATPase subunit alpha-1
MGKGVGRDKYEPAAVSEHGDKKKAKKERDMDELKKEVSMDDHKLSLDELHRKYGTDLSRG
LTTARAAEILARDGPNALTPPPTTPEWVKFCRQLFGGFSMLLWIGAVLCFLAYGIQAATE
EEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNGEKMSINA
EEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETRNI
AFFSTNCVEGTARGIVVYTGDRTVMGRIATLASGLEGGQTPIAAEIEHFIHIITGVAVFL
GVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLE
AVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWLALS
RIAGLCNRAVFQANQDNLPILKRAVAGDASESALLKCIEVCCGSVKEMRERYTKIVEIPF
NSTNKYQLSIHKNANAGEPRHLLVMKGAPERILDRCSSILIHGKEQPLDEELKDAFQNAY
LELGGLGERVLGFCHLLLPDEQFPEGFQFDTDDVNFPVDNLCFVGLISMIDPPRAAVPDA
VGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDARA
CVVHGSDLKDMTPEQLDDILKYHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDS
PALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTS
NIPEITPFLIFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKRQPRNPQTD
KLVNERLISMAYGQIGMIQALGGFFTYFVIMAENGFLPNHLLGIRVTWDDRWINDVEDSY
GQQWTYEQRKIVEFTCHTAFFVSIVVVQWADLVICKTRRNSVFQQGMKNKILIFGLFEET
ALAAFLSYCPGMGVALRMYPLKPTWWFCAFPYSLLIFVYDEVRKLIIRRRPGGWVEKETY
Y
|
| External Links |
|---|
| GenBank ID Protein
| AAI23865.1 |
| UniProtKB/Swiss-Prot ID
| Q08DA1 |
| UniProtKB/Swiss-Prot Entry Name
| AT1A1_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BC123864 |
| GeneCard ID
| ATP1A1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
