| Identification |
|---|
| BMDB Protein ID
| BMDBP00147 |
| Secondary Accession Numbers
| None |
| Name
| ATPase GET3 |
| Synonyms
|
Not Available
|
| Gene Name
| GET3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Inorganic ion transport and metabolism |
| Specific Function
| ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 7 |
| Locus
| Not Available |
| SNPs
| GET3 |
| Gene Sequence
|
>1047 bp
ATGGCGGCAGGGGTGGCCGGGTGGGGGGTTGAGGCAGAGGAGTTCGAGGATGCCCCTGAT
GTGGAGCCGCTGGAGCCCACGCTTAGCAACATCATCGAGCAGCGCAGCCTTAAGTGGATC
TTCGTTGGGGGCAAAGGTGGAGTTGGCAAAACAACCTGCAGCTGCAGCCTAGCAGTCCAG
CTGTCCAAGGGGCGGGAGAGTGTTCTGATCATCTCCACCGACCCAGCCCACAACATCTCC
GATGCATTTGACCAGAAGTTCTCCAAGGTGCCTACCAAGGTCAAAGGCTATGACAACCTC
TTTGCCATGGAGATTGACCCCAGCCTGGGCGTGGCGGAGCTGCCAGACGAGTTCTTTGAA
GAGGACAACATGCTGAGCATGGGCAAAAAGATGATGCAAGAAGCTATGAGCGCATTCCCA
GGCATCGACGAGGCCATGAGCTACGCAGAGGTGATGAGGCTGGTGAAGGGCATGAACTTC
TCCGTGGTGGTGTTCGACACTGCGCCCACAGGCCACACGCTGAGGCTGCTCAACTTCCCC
ACCATCGTCGAGCGGGGGCTTGGCCGCCTCATGCAGATCAAGAACCAGATCAGCCCCTTC
ATCTCACAGATGTGCAACATGCTGGGCCTCGGCGACATGAACGCAGACCAGCTGGCCTCC
AAGCTAGAGGAGACGCTGCCTGTCATCCGCTCGGTCAGCGAGCAGTTCAAGGACCCTGAG
CAAACAACCTTCATCTGTGTGTGCATCGCGGAGTTCCTGTCCCTGTATGAAACCGAACGG
CTGATCCAGGAGCTGGCCAAGTGCAAGATTGACACGCACAACATCATCGTCAACCAGCTC
GTCTTCCCTGATCCCGAGAAGCCCTGCAAGATGTGTGAGGCCCGCCACAAGATCCAAGCC
AAGTACCTGGATCAGATGGAGGACCTATATGAAGACTTCCACATTGTGAAGCTGCCGCTG
CTGCCCCATGAGGTTCGGGGAGCAGACAAGGTCAACACCTTCTCCGCTCTCCTCCTGGAG
CCCTACAAGCCCCCCAGCGCGCAGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 348 |
| Molecular Weight
| 38793.0 |
| Theoretical pI
| 4.54 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Arsenical pump-driving ATPase
MAAGVAGWGVEAEEFEDAPDVEPLEPTLSNIIEQRSLKWIFVGGKGGVGKTTCSCSLAVQ
LSKGRESVLIISTDPAHNISDAFDQKFSKVPTKVKGYDNLFAMEIDPSLGVAELPDEFFE
EDNMLSMGKKMMQEAMSAFPGIDEAMSYAEVMRLVKGMNFSVVVFDTAPTGHTLRLLNFP
TIVERGLGRLMQIKNQISPFISQMCNMLGLGDMNADQLASKLEETLPVIRSVSEQFKDPE
QTTFICVCIAEFLSLYETERLIQELAKCKIDTHNIIVNQLVFPDPEKPCKMCEARHKIQA
KYLDQMEDLYEDFHIVKLPLLPHEVRGADKVNTFSALLLEPYKPPSAQ
|
| External Links |
|---|
| GenBank ID Protein
| AAI42126.1 |
| UniProtKB/Swiss-Prot ID
| A5PJI5 |
| UniProtKB/Swiss-Prot Entry Name
| GET3_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC142125 |
| GeneCard ID
| GET3 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
