Showing Protein ATPase GET3 (BMDBP00147)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00147 |
| Secondary Accession Numbers | None |
| Name | ATPase GET3 |
| Synonyms | Not Available |
| Gene Name | GET3 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Inorganic ion transport and metabolism |
| Specific Function | ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting. |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 7 |
| Locus | Not Available |
| SNPs | GET3 |
| Gene Sequence |
>1047 bp ATGGCGGCAGGGGTGGCCGGGTGGGGGGTTGAGGCAGAGGAGTTCGAGGATGCCCCTGAT GTGGAGCCGCTGGAGCCCACGCTTAGCAACATCATCGAGCAGCGCAGCCTTAAGTGGATC TTCGTTGGGGGCAAAGGTGGAGTTGGCAAAACAACCTGCAGCTGCAGCCTAGCAGTCCAG CTGTCCAAGGGGCGGGAGAGTGTTCTGATCATCTCCACCGACCCAGCCCACAACATCTCC GATGCATTTGACCAGAAGTTCTCCAAGGTGCCTACCAAGGTCAAAGGCTATGACAACCTC TTTGCCATGGAGATTGACCCCAGCCTGGGCGTGGCGGAGCTGCCAGACGAGTTCTTTGAA GAGGACAACATGCTGAGCATGGGCAAAAAGATGATGCAAGAAGCTATGAGCGCATTCCCA GGCATCGACGAGGCCATGAGCTACGCAGAGGTGATGAGGCTGGTGAAGGGCATGAACTTC TCCGTGGTGGTGTTCGACACTGCGCCCACAGGCCACACGCTGAGGCTGCTCAACTTCCCC ACCATCGTCGAGCGGGGGCTTGGCCGCCTCATGCAGATCAAGAACCAGATCAGCCCCTTC ATCTCACAGATGTGCAACATGCTGGGCCTCGGCGACATGAACGCAGACCAGCTGGCCTCC AAGCTAGAGGAGACGCTGCCTGTCATCCGCTCGGTCAGCGAGCAGTTCAAGGACCCTGAG CAAACAACCTTCATCTGTGTGTGCATCGCGGAGTTCCTGTCCCTGTATGAAACCGAACGG CTGATCCAGGAGCTGGCCAAGTGCAAGATTGACACGCACAACATCATCGTCAACCAGCTC GTCTTCCCTGATCCCGAGAAGCCCTGCAAGATGTGTGAGGCCCGCCACAAGATCCAAGCC AAGTACCTGGATCAGATGGAGGACCTATATGAAGACTTCCACATTGTGAAGCTGCCGCTG CTGCCCCATGAGGTTCGGGGAGCAGACAAGGTCAACACCTTCTCCGCTCTCCTCCTGGAG CCCTACAAGCCCCCCAGCGCGCAGTAG |
| Protein Properties | |
| Number of Residues | 348 |
| Molecular Weight | 38793.0 |
| Theoretical pI | 4.54 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>Arsenical pump-driving ATPase MAAGVAGWGVEAEEFEDAPDVEPLEPTLSNIIEQRSLKWIFVGGKGGVGKTTCSCSLAVQ LSKGRESVLIISTDPAHNISDAFDQKFSKVPTKVKGYDNLFAMEIDPSLGVAELPDEFFE EDNMLSMGKKMMQEAMSAFPGIDEAMSYAEVMRLVKGMNFSVVVFDTAPTGHTLRLLNFP TIVERGLGRLMQIKNQISPFISQMCNMLGLGDMNADQLASKLEETLPVIRSVSEQFKDPE QTTFICVCIAEFLSLYETERLIQELAKCKIDTHNIIVNQLVFPDPEKPCKMCEARHKIQA KYLDQMEDLYEDFHIVKLPLLPHEVRGADKVNTFSALLLEPYKPPSAQ |
| External Links | |
| GenBank ID Protein | AAI42126.1 |
| UniProtKB/Swiss-Prot ID | A5PJI5 |
| UniProtKB/Swiss-Prot Entry Name | GET3_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | BC142125 |
| GeneCard ID | GET3 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |