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Identification
BMDB Protein ID BMDBP00148
Secondary Accession Numbers None
Name Glutamine synthetase
Synonyms Not Available
Gene Name GLUL
Protein Type Enzyme
Biological Properties
General Function Amino acid transport and metabolism
Specific Function Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (By similarity). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts. Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating membrane localization and activation of the GTPase RHOJ, possibly by promoting RHOJ palmitoylation. May act as a palmitoyltransferase for RHOJ: able to autopalmitoylate and then transfer the palmitoyl group to RHOJ (By similarity). Plays a role in ribosomal 40S subunit biogenesis (By similarity).
Pathways Not Available
Reactions Not Available
GO Classification Not Available
Cellular Location Not Available
Gene Properties
Chromosome Location 16
Locus Not Available
SNPs GLUL
Gene Sequence
>1122 bp
ATGGCCACCTCGGCGAGCTCCCACTTGAACAAAGGCATCAAGCAGGTGTACATGGCCCTA
CCTCAGGGTGATAAAGTCCAAGCTATGTACATCTGGATCGACGGTACTGGAGAAGGACTG
CGCTGCAAGACCCGAACCTTGGATTCTGAACCCAAGTGTATAGAAGAGTTGCCCGAGTGG
AATTTTGATGGCTCTAGTACTTTTCAGTCTGAAGGCTCCAACAGTGACATGTATCTTGTC
CCCGCTGCCATGTTTCGGGACCCTTTCCGCAAGGACCCCAACAAGCTGGTGTTCTGTGAA
GTCTTCAAGTACAACCGAAAGCCTGCAGAGACCAATTTAAGGCACACCTGTAAACGGATA
ATGGACATGGTGAGCAACCAGCGCCCCTGGTTTGGAATGGAGCAGGAATATACCCTCATG
GGCACTGATGGGCACCCCTTTGGTTGGCCTTCCAATGGCTTTCCTGGGCCCCAAGGTCCC
TACTACTGTGGTGTGGGAGCGGACAAGGCCTACGGCAGGGATATTGTGGAGGCTCACTAC
AGGGCCTGCTTGTACGCCGGCATCAAGATCGGGGGCACGAATGCCGAGGTCATGCCTGCA
CAGTGGGAATTCCAGATAGGACCCTGTGAAGGAATCGACATGGGCGATCATCTCTGGGTG
GCCCGTTTCATCTTGCATCGTGTGTGTGAAGACTTCGGAGTGATCGCCACCTTTGATCCT
AAGCCCATTCCTGGAAACTGGAATGGTGCTGGCTGCCACACCAACTTTAGCACCAAGGCC
ATGCGAGAGGAGAATGGTCTGAAGTACATTGAGGAGGCCATTGAGAAGCTAAGCAAGCGC
CACCAGTACCACATCCGAGCCTACGATCCCAAGGGGGGCCTGGACAACGCCCGGCGCCTA
ACTGGGTTCCACGAAACCTCCAACATCAACGACTTCTCTGCCGGCGTGGCCAACCGTGGT
GCTAGCATCCGCATCCCCCGGACTGTTGGCCAGGAGAAGAAGGGCTACTTCGAAGACCGT
CGCCCATCTGCCAACTGTGACCCCTTCGCCGTGACCGAAGCCCTCATCCGCACATGTCTT
CTGAACGAAACTGGCGACGAGCCCTTCCAGTACAAGAACTAA
Protein Properties
Number of Residues 373
Molecular Weight 42031.0
Theoretical pI 6.83
Pfam Domain Function Not Available
Signals
  • None
Transmembrane Regions Not Available
Protein Sequence
>Glutamine synthetase
MATSASSHLNKGIKQVYMALPQGDKVQAMYIWIDGTGEGLRCKTRTLDSEPKCIEELPEW
NFDGSSTFQSEGSNSDMYLVPAAMFRDPFRKDPNKLVFCEVFKYNRKPAETNLRHTCKRI
MDMVSNQRPWFGMEQEYTLMGTDGHPFGWPSNGFPGPQGPYYCGVGADKAYGRDIVEAHY
RACLYAGIKIGGTNAEVMPAQWEFQIGPCEGIDMGDHLWVARFILHRVCEDFGVIATFDP
KPIPGNWNGAGCHTNFSTKAMREENGLKYIEEAIEKLSKRHQYHIRAYDPKGGLDNARRL
TGFHETSNINDFSAGVANRGASIRIPRTVGQEKKGYFEDRRPSANCDPFAVTEALIRTCL
LNETGDEPFQYKN
GenBank ID Protein AAI03100.1
UniProtKB/Swiss-Prot ID P15103
UniProtKB/Swiss-Prot Entry Name GLNA_BOVIN
PDB IDs Not Available
GenBank Gene ID BC103099
GeneCard ID GLUL
GenAtlas ID Not Available
HGNC ID Not Available
References
General References Not Available