| Identification |
|---|
| BMDB Protein ID
| BMDBP00148 |
| Secondary Accession Numbers
| None |
| Name
| Glutamine synthetase |
| Synonyms
|
Not Available
|
| Gene Name
| GLUL |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Amino acid transport and metabolism |
| Specific Function
| Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (By similarity). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts. Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating membrane localization and activation of the GTPase RHOJ, possibly by promoting RHOJ palmitoylation. May act as a palmitoyltransferase for RHOJ: able to autopalmitoylate and then transfer the palmitoyl group to RHOJ (By similarity). Plays a role in ribosomal 40S subunit biogenesis (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 16 |
| Locus
| Not Available |
| SNPs
| GLUL |
| Gene Sequence
|
>1122 bp
ATGGCCACCTCGGCGAGCTCCCACTTGAACAAAGGCATCAAGCAGGTGTACATGGCCCTA
CCTCAGGGTGATAAAGTCCAAGCTATGTACATCTGGATCGACGGTACTGGAGAAGGACTG
CGCTGCAAGACCCGAACCTTGGATTCTGAACCCAAGTGTATAGAAGAGTTGCCCGAGTGG
AATTTTGATGGCTCTAGTACTTTTCAGTCTGAAGGCTCCAACAGTGACATGTATCTTGTC
CCCGCTGCCATGTTTCGGGACCCTTTCCGCAAGGACCCCAACAAGCTGGTGTTCTGTGAA
GTCTTCAAGTACAACCGAAAGCCTGCAGAGACCAATTTAAGGCACACCTGTAAACGGATA
ATGGACATGGTGAGCAACCAGCGCCCCTGGTTTGGAATGGAGCAGGAATATACCCTCATG
GGCACTGATGGGCACCCCTTTGGTTGGCCTTCCAATGGCTTTCCTGGGCCCCAAGGTCCC
TACTACTGTGGTGTGGGAGCGGACAAGGCCTACGGCAGGGATATTGTGGAGGCTCACTAC
AGGGCCTGCTTGTACGCCGGCATCAAGATCGGGGGCACGAATGCCGAGGTCATGCCTGCA
CAGTGGGAATTCCAGATAGGACCCTGTGAAGGAATCGACATGGGCGATCATCTCTGGGTG
GCCCGTTTCATCTTGCATCGTGTGTGTGAAGACTTCGGAGTGATCGCCACCTTTGATCCT
AAGCCCATTCCTGGAAACTGGAATGGTGCTGGCTGCCACACCAACTTTAGCACCAAGGCC
ATGCGAGAGGAGAATGGTCTGAAGTACATTGAGGAGGCCATTGAGAAGCTAAGCAAGCGC
CACCAGTACCACATCCGAGCCTACGATCCCAAGGGGGGCCTGGACAACGCCCGGCGCCTA
ACTGGGTTCCACGAAACCTCCAACATCAACGACTTCTCTGCCGGCGTGGCCAACCGTGGT
GCTAGCATCCGCATCCCCCGGACTGTTGGCCAGGAGAAGAAGGGCTACTTCGAAGACCGT
CGCCCATCTGCCAACTGTGACCCCTTCGCCGTGACCGAAGCCCTCATCCGCACATGTCTT
CTGAACGAAACTGGCGACGAGCCCTTCCAGTACAAGAACTAA
|
| Protein Properties |
|---|
| Number of Residues
| 373 |
| Molecular Weight
| 42031.0 |
| Theoretical pI
| 6.83 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Glutamine synthetase
MATSASSHLNKGIKQVYMALPQGDKVQAMYIWIDGTGEGLRCKTRTLDSEPKCIEELPEW
NFDGSSTFQSEGSNSDMYLVPAAMFRDPFRKDPNKLVFCEVFKYNRKPAETNLRHTCKRI
MDMVSNQRPWFGMEQEYTLMGTDGHPFGWPSNGFPGPQGPYYCGVGADKAYGRDIVEAHY
RACLYAGIKIGGTNAEVMPAQWEFQIGPCEGIDMGDHLWVARFILHRVCEDFGVIATFDP
KPIPGNWNGAGCHTNFSTKAMREENGLKYIEEAIEKLSKRHQYHIRAYDPKGGLDNARRL
TGFHETSNINDFSAGVANRGASIRIPRTVGQEKKGYFEDRRPSANCDPFAVTEALIRTCL
LNETGDEPFQYKN
|
| External Links |
|---|
| GenBank ID Protein
| AAI03100.1 |
| UniProtKB/Swiss-Prot ID
| P15103 |
| UniProtKB/Swiss-Prot Entry Name
| GLNA_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC103099 |
| GeneCard ID
| GLUL |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
