| Identification |
|---|
| BMDB Protein ID
| BMDBP00170 |
| Secondary Accession Numbers
| None |
| Name
| Dynamin-2 |
| Synonyms
|
Not Available
|
| Gene Name
| DNM2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in GTP binding |
| Specific Function
| Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Plays an important role in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis. Regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 7 |
| Locus
| Not Available |
| SNPs
| DNM2 |
| Gene Sequence
|
>2601 bp
ATGGGCAACCGCGGGATGGAAGAGCTGATCCCGCTGGTCAACAAGCTGCAGGATGCCTTC
AGTTCCATCGGCCAGAGCTGCCACCTGGACCTGCCGCAGATCGCCGTGGTGGGCGGCCAG
AGCGCCGGCAAGAGCTCTGTGCTCGAGAACTTCGTGGGCCGGGACTTCCTTCCCCGAGGT
TCAGGAATCGTCACTCGGCGGCCTCTCATCCTGCAGCTCATCTTCTCAAAAACAGAATAT
GCCGAGTTTTTGCACTGCAAGTCCAGAAAGTTTACAGACTTTGAGGAAGTCCGACAGGAG
ATCGAAGCGGAGACTGACAGGGTCACGGGGACCAACAAGGGCATCTCCCCAGTGCCCATT
AACCTGCGGATCTACTCGCCACACGTGTTGAACCTGACCCTCATCGACCTCCCAGGCATC
ACAAAGGTGCCTGTGGGGGACCAGCCCCAGGATATCGAGTACCAGATCAAGGACATGATC
TTGCAGTTCATCAGCCGGGAAAGCAGCCTCATCCTTGCTGTCACCCCCGCCAACATGGAC
CTGGCCAACTCAGACGCCCTAAAGCTGGCCAAGGAGGTCGATCCTCAAGGCCTGCGGACC
ATCGGCGTCATCACCAAACTCGACCTGATGGACGAAGGCACGGATGCCAGGGATGTCCTG
GAGAACAAGCTACTCCCCTTGAGGAGAGGCTACATTGGAGTGGTCAACCGCAGCCAGAAG
GATATTGAGGGCAAGAAGGACATCCGCACAGCACTGGCGGCCGAGAGGAAGTTTTTCCTC
TCCCACCCAGCCTACCGGCACATAGCTGACCGCATGGGCACCCCGCACCTGCAGAAGACT
CTGAATCAGCAACTGACCAACCACATCCGGGAATCACTGCCGGCCCTGCGCAGCAAGCTG
CAGAGCCAGCTGCTATCCCTGGAGAAGGAGGTGGAGGAGTACAAGAACTTCCGGCCCGAT
GACCCCACACGCAAGACCAAAGCTCTCCTGCAGATGGTCCAGCAGTTTGGGGTGGACTTT
GAGAAGAGGATTGAGGGCTCTGGAGACCAGGTGGACACACTGGAGCTCTCTGGGGGCGCC
CGGATCAATCGCATCTTCCACGAGCGATTTCCCTTCGAGCTGGTGAAGATGGAGTTTGAT
GAGAAAGACTTAAGACGGGAGATCAGCTACGCCATTAAAAATATCCACGGAGTCAGGACC
GGGCTCTTCACCCCGGACTTGGCATTCGAGGCCATTGTGAAAAAGCAGGTCGTCAAGCTG
AAAGAGCCCTGTCTGAAATGTGTCGACCTGGTTATCCAGGAGCTAATCAATACAGTTAGG
CAGTGTACCAGTAAGCTCAGCTCCTACCCGCGGTTGCGAGAGGAAACGGAACGCATCGTC
ACCACTTACATCCGGGAACGGGAGGGGAGGACCAAGGACCAGATTCTTCTTCTGATTGAC
ATTGAGCAGTCCTACATCAACACCAACCACGAGGACTTCATTGGATTTGCCAACGCCCAG
CAGAGGAGCACACAGCTGAATAAGAAGAGAGCCGTCCCCAACCAGGTGATCCGCAGGGGC
TGGCTAACCATCAACAATATCAGCCTGATGAAGGGAGGCTCCAAGGAGTACTGGTTCGTG
CTGACGGCCGAGTCACTGTCCTGGTACAAGGATGAGGAGGAGAAAGAGAAGAAGTACATG
CTGCCTCTGGACAACCTCAAAATCCGTGACGTGGAGAAGGGCTTCATGTCCAACAAGCAC
GTCTTCGCCATCTTCAACACAGAGCAGAGGAATGTCTACAAGGACCTGCGGCAGATCGAG
CTGGCCTGTGACTCCCAGGAGGACGTGGACAGCTGGAAGGCCTCATTCCTCCGAGCTGGG
GTCTATCCAGAGAAGGACCAGGCAGAAAATGAGGATGGAGCCCAGGAGAACACCTTCTCC
ATGGACCCGCAGTTGGAGCGGCAGGTGGAGACCATTCGCAACCTGGTGGACTCGTACGTG
GCCATAATCAACAAGTCCATCCGTGACCTCATGCCAAAGACCATCATGCACCTCATGATC
AACAACACGAAGGCCTTCATCCACTATGAGCTGCTGGCCTACCTGTACTCGTCGGCGGAC
CAGAGCAGCCTCATGGAAGAGTCGGCTGACCAGGCCCAGCGGCGGGATGACATGCTTCGC
ATGTACCACGCGCTCAAGGAGGCACTCAACATCATTGGGGACATCAGCACCAGCACTGTG
TCCACTCCCGTGCCCCCACCCGTTGACGACACCTGGATCCAGAACACCAGCAGCCACAGC
CCCACTCCGCAGCGCCGGCCCGTATCCAGCGTGCACCCCCCAGGCCGGCCCCCAGCAGTG
AGGGGTCCCACCCCAGGGCCACCCCTGATTCCTGTGCCGGTGGGGCCAGCTTCCTTCTCA
GCGCCCCCGATCCCATCCCGGCCCGGCCCCCACCCCGGCGTGTTTGCCAACAACGACCCC
TTCTCGGCCCCACCTCAGATCCCATCTCGGCCGGCTCGGATTCCACCCGGCATTCCCCCT
GGAGTGCCCAGCAGAAGACCCCCTGCTGCGCCCAGCCGGCCCACCATTATCCGCCCAGCC
GAGCCATCTCTGCTCGACTAG
|
| Protein Properties |
|---|
| Number of Residues
| 866 |
| Molecular Weight
| 97836.0 |
| Theoretical pI
| 7.69 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 29-49
- 61-81
- 118-138
- 148-168
- 171-191
- 210-230
- 255-275
- 292-312
- 321-341
|
| Protein Sequence
|
>Dynamin-2
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRG
SGIVTRRPLILQLIFSKTEYAEFLHCKSRKFTDFEEVRQEIEAETDRVTGTNKGISPVPI
NLRIYSPHVLNLTLIDLPGITKVPVGDQPQDIEYQIKDMILQFISRESSLILAVTPANMD
LANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQK
DIEGKKDIRTALAAERKFFLSHPAYRHIADRMGTPHLQKTLNQQLTNHIRESLPALRSKL
QSQLLSLEKEVEEYKNFRPDDPTRKTKALLQMVQQFGVDFEKRIEGSGDQVDTLELSGGA
RINRIFHERFPFELVKMEFDEKDLRREISYAIKNIHGVRTGLFTPDLAFEAIVKKQVVKL
KEPCLKCVDLVIQELINTVRQCTSKLSSYPRLREETERIVTTYIREREGRTKDQILLLID
IEQSYINTNHEDFIGFANAQQRSTQLNKKRAVPNQVIRRGWLTINNISLMKGGSKEYWFV
LTAESLSWYKDEEEKEKKYMLPLDNLKIRDVEKGFMSNKHVFAIFNTEQRNVYKDLRQIE
LACDSQEDVDSWKASFLRAGVYPEKDQAENEDGAQENTFSMDPQLERQVETIRNLVDSYV
AIINKSIRDLMPKTIMHLMINNTKAFIHYELLAYLYSSADQSSLMEESADQAQRRDDMLR
MYHALKEALNIIGDISTSTVSTPVPPPVDDTWIQNTSSHSPTPQRRPVSSVHPPGRPPAV
RGPTPGPPLIPVPVGPASFSAPPIPSRPGPHPGVFANNDPFSAPPQIPSRPARIPPGIPP
GVPSRRPPAAPSRPTIIRPAEPSLLD
|
| External Links |
|---|
| GenBank ID Protein
| AAI46260.1 |
| UniProtKB/Swiss-Prot ID
| A6H7I5 |
| UniProtKB/Swiss-Prot Entry Name
| DYN2_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC146259 |
| GeneCard ID
| DNM2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
